The Small GTP-Binding Protein RhoA Regulates a Delayed Rectifier Potassium Channel [PDF]
Cell, 1998 Tyrosine kinases activated by G protein-coupled receptors can phosphorylate and thereby suppress the activity of the delayed rectifier potassium channel Kv1.2. Using a yeast two-hybrid screen, we identified the small GTP-binding protein RhoA as a necessary component in this process.
Ernest G Peralta, E G Peralta
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The Small GTP-Binding Protein RhoA Regulates c-Jun by a ROCK-JNK Signaling Axis [PDF]
Molecular Cell, 2004 RhoA regulates the actin cytoskeleton and the expression of genes associated with cell proliferation. This includes c-fos and c-jun, which are members of the AP1 family of transcription factors that play a key role in normal and aberrant cell growth.
Shuh Narumiya +2 more
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CD20 tails interact with the 14-3-3/GEF-H1 complex and microtubule network upon PKCδ phosphorylation [PDF]
The EMBO JournalCD20 is a four-helix transmembrane protein specifically expressed in B-cells that serves as a prominent target of therapeutic anti-CD20 antibodies. It is localized in a membrane nanocluster harboring the B-cell antigen receptor of IgD class (IgD-BCR ...
Kathrin Kläsener +12 more
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Regulation of phospholipase C-delta by GTP-binding proteins-rhoA as an inhibitory modulator
Biochimica Et Biophysica Acta - Molecular Cell Research, 1998 The regulation of Phospholipase C (PLC)delta activity remains obscure. These studies show that PLCdelta1 activity is significantly enhanced by both guanosine thiotriphosphate (GTPgammaS) and Clostridium botulinum exoenzyme C3 (C3) but not by aluminium fluoride.
Alun Hughes, Joanne S Lymn, J S Lymn
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Arp2/3-Branched Actin Maintains an Active Pool of GTP-RhoA and Controls RhoA Abundance
Cells, 2019 Small GTPases regulate cytoskeletal dynamics, cell motility, and division under precise spatiotemporal control. Different small GTPases exhibit cross talks to exert feedback response or to act in concert during signal transduction.
Yuxing Huang +3 more
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Activation of rat liver phospholipase D by the small GTP-binding protein RhoA
Journal of Biological Chemistry, 1994 Stimulation of phospholipase D by guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) in rat liver plasma membranes indicates the involvement of GTP-binding proteins. We used RhoGDI, an inhibitor of GDP dissociation from small GTP-binding proteins of the Rho family, to determine the involvement of these proteins.
Kenneth Malcolm, R G Qiu, M Symons
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Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1993 The Ras-related small GTP-binding proteins are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The interconversion of the active, GTP-bound form of the protein to the inactive, GDP-bound form is influenced by two types of regulatory proteins, those that alter the intrinsic GTPase ...
Louis Staudt
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Rho/ROCK Signaling Pathway in Kidney Diseases: Mechanisms and Therapeutic Perspectives [PDF]
BiomedicinesRho GTPases are a group of guanosine triphosphate (GTP)-binding proteins with a relative molecular weight of about 20–30 kD, and 22 different Rho GTPases have been identified in mammalian cells, among which RhoA, Rac1 and Cdc42 are the most well-studied.
Wei Xiong +4 more
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Frontiers in Immunology, 2022 Strategies based on intracellular expression of artificial binding domains present several advantages over manipulating nucleic acid expression or the use of small molecule inhibitors.
Laura Keller +14 more
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Phosphorylation and Activation of RhoA by ERK in Response to Epidermal Growth Factor Stimulation. [PDF]
PLoS ONE, 2016 The small GTPase RhoA has been implicated in various cellular activities, including the formation of stress fibers, cell motility, and cytokinesis. In addition to the canonical GTPase cycle, recent findings have suggested that phosphorylation further ...
Junfeng Tong +3 more
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