Neurobiology of Disease, 2019 Mutations in parkin, encoded by the PARK2 gene, causes early-onset familial Parkinson's disease (PD), but dysfunctional parkin has also been implicated in sporadic PD.
Helle Bogetofte +13 more
doaj +1 more source
Molecular and cellular basis of the internalization of "Bartonella henselae" by human endothelial cells [PDF]
, 2007 The facultative intracellular bacterium Bartonella henselae enters human endothelial cells either passively by conventional phagocytosis or actively by a pathogen-triggered process known as invasome-mediated internalization.
Rhomberg, Thomas Alexander
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Molecular Cancer, 2017 Background Pancreatic cancer, one of the top two most fatal cancers, is characterized by a desmoplastic reaction that creates a dense microenvironment, promoting hypoxia and inducing the epithelial-to-mesenchymal transition (EMT) to facilitate invasion ...
Hongzhe Li +10 more
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The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering [PDF]
, 2004 Glycine receptors (GlyRs) and specific subtypes of GABA(A) receptors are clustered at synapses by the multidomain protein gephyrin, which in turn is translocated to the cell membrane by the GDP-GTP exchange factor collybistin.
Ward, H +53 more
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The non-catalytic carboxyl-terminal domain of ARFGAP1 regulates actin cytoskeleton reorganization by antagonizing the activation of Rac1. [PDF]
PLoS ONE, 2011 The regulation of the actin cytoskeleton and membrane trafficking is coordinated in mammalian cells. One of the regulators of membrane traffic, the small GTP-binding protein ARF1, also activates phosphatidylinositol kinases that in turn affect actin ...
Ka Yu Siu +6 more
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Topological and functional properties of the small GTPases protein interaction network. [PDF]
PLoS ONE, 2012 Small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) regulate key cellular processes such as signal transduction, cell proliferation, cell motility, and vesicle transport.
Anna Delprato
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Rho GTPases and regulation of cell migration and polarization in human corneal epithelial cells. [PDF]
PLoS ONE, 2013 PURPOSE:Epithelial cell migration is required for regeneration of tissues and can be defective in a number of ocular surface diseases. This study aimed to determine the expression pattern of Rho family small G-proteins in human corneal epithelial cells ...
Aihua Hou +5 more
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Computer vision profiling of neurite outgrowth mordphodynamics reveals spatio-temporal modularity of Rho GTPase signaling [PDF]
, 2014 Neurite outgrowth is essential to build the neuronal processes that produce axons and dendrites that connect the adult brain. In cultured cells, the neurite outgrowth process is highly dynamic, and consists of a series of repetitive morphogenetic sub ...
Fusco, Ludovico
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Rho-kinase inhibition ameliorates metabolic disorders through activation of AMPK pathway in mice. [PDF]
PLoS ONE, 2014 BACKGROUND: Metabolic disorders, caused by excessive calorie intake and low physical activity, are important cardiovascular risk factors. Rho-kinase, an effector protein of the small GTP-binding protein RhoA, is an important cardiovascular therapeutic ...
Kazuki Noda +11 more
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Selective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human Natural Killer cells. [PDF]
PLoS ONE, 2013 We have analyzed the effects of fluvastatin, an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase involved in mevalonate synthesis, on human NK cell-mediated anti-tumor cytolysis.
Alessandro Poggi +3 more
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