Results 61 to 70 of about 3,677,140 (187)

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

Phytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao, Zhangyun Li, Quanzhou Peng, Shuqun Zhang   +3 more
wiley   +1 more source

The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii [PDF]

, 2011
Background: The interferon-inducible immunity-related GTPases (IRG proteins/p47 GTPases) are a distinctive family of GTPases that function as powerful cell-autonomous resistance factors.
Khaminets, Aliaksandr, Wolf, Eva, Vopper, G., Pawlowski, Nikolaus, Schmidt, Andreas, Lange Rita, Aliaksandr Khaminets, Nikolaus Pawlowski, Papic, Natasa, Gabriela Vopper, Papic Natasa, Pawlowski, N., Uthaiah, Revathy C., Natasa Papic, Howard, J. C., Hunn, Julia P., Uthaiah, R. C., Andreas Schmidt, Eva Wolf, Hunn, J., Vopper, Gabriela, Julia P Hunn, Schmidt Andreas, Rita Lange, Sascha Martens, Uthaiah, Revathy Chottekalapanda, Martens Sascha, Wolf, E., Jonathan C Howard, Lange, Rita, Martens, Sascha, Papic, N., Wolf Eva, Lange, R., Hunn Julia P, Khaminets Aliaksandr, Howard, Jonathan C., Howard, J., Howard Jonathan C, Schmidt, A., Uthaiah Revathy C, Khaminets, A., Pawlowski Nikolaus, Revathy C Uthaiah, Uthaiah, R., Martens, S., Hunn, J. P., Hunn, Julia, Vopper Gabriela   +48 more
core   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Cell wall stress depolarizes cell growth via hyperactivation of RHO1 [PDF]

, 1999
Cells sense and physiologically respond to environmental stress via signaling pathways. Saccharomyces cerevisiae cells respond to cell wall stress by transiently depolarizing the actin cytoskeleton.
Hall, M. N., Delley, P. A., Pierre-Alain Delley, Michael N. Hall   +3 more
core   +1 more source

The Emerging Role of Guanine Exchange Factors in ALS and other neurodegenerative diseases

Frontiers in Cellular Neuroscience, 2014
Small GTPases participate in a broad range of cellular processes such as proliferation, differentiation and migration. The exchange of GDP for GTP resulting in the activation of these GTPases is catalyzed by a group of enzymes called guanine nucleotide ...
Cristian eDroppelmann, Danae eCampos-Melo, Kathryn eVolkening, Kathryn eVolkening, Michael Joseph Strong, Michael Joseph Strong   +5 more
doaj   +1 more source

The Caenorhabditis elegans small GTP-binding protein RhoA is enriched in the nerve ring and sensory neurons during larval development.

Journal of Biological Chemistry, 1994
p21 Ras has been implicated in vulval differentiation in Caenorhabditis elegans. We now describe the characteristics during nematode development of the related p21 RhoA which has been ascribed a morphological role in mammals. The CeRhoA cDNA isolated in this study encodes a sequence of 192 amino acids residues with 87.6% identity to human RhoA. Genomic
Chen, W., Lim, L.
openaire   +2 more sources

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira, José Arion Da Silva Moura, Pedro César de Souza, Marcelo Arthur Dias da Costa Santana, Matheus Vinicius Guimarães de Melo, Douglas Carvalho Francisco Viana, Marina Galdino Da Rocha Pitta, Isabella Luiza Ralph de Oliveira, Maira Galdino Da Rocha Pitta   +8 more
wiley   +1 more source

GTP and Ca2+ Modulate the Inositol 1,4,5-Trisphosphate-Dependent Ca2+ Release in Streptolysin O-Permeabilized Bovine Adrenal Chromaffin Cells [PDF]

, 1991
The inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release was studied using streptolysin O-permeabilized bovine adrenal chromaffin cells. The IP3-induced Ca2+ release was followed by Ca2+ reuptake into intracellular compartments.
Föhr, K. J., Ahnert-Hilger, G., Scott, J., Gratzl, Manfred, Stecher, B., M. Gratzl, K. J. Föhr, J. Scott, G. Ahnert-Hilger, B. Stecher   +9 more
core   +1 more source

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 468-484, September 2026.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source