Results 51 to 60 of about 3,677,140 (187)

ADP-ribosylation of the ras-related, GTP-binding protein RhoA inhibits lymphocyte-mediated cytotoxicity.

Journal of Biological Chemistry, 1992
The Rho proteins are identified as a subgroup of the Ras superfamily of low molecular weight GTP-binding proteins. We have studied the expression of these proteins in human cytotoxic natural killer cells and found that RhoA is the most abundantly expressed member of the Rho family. The Rho proteins are specific substrates for ADP-ribosylation catalyzed
P, Lang, L, Guizani, I, Vitté-Mony, R, Stancou, O, Dorseuil, G, Gacon, J, Bertoglio   +6 more
openaire   +2 more sources

Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac. [PDF]

PLoS ONE, 2010
The intracellular bacterium Chlamydia trachomatis causes infections of urogenital tract, eyes or lungs. Alignment reveals homology of CT166, a putative effector protein of urogenital C. trachomatis serovars, with the N-terminal glucosyltransferase domain
Jessica Thalmann, Katrin Janik, Martin May, Kirsten Sommer, Jenny Ebeling, Fred Hofmann, Harald Genth, Andreas Klos   +7 more
doaj   +1 more source

The pH dependence of polymerization and bundling by the essential bacterial cytoskeltal protein FtsZ [PDF]

, 2011
There is a growing body of evidence that bacterial cell division is an intricate coordinated process of comparable complexity to that seen in eukaryotic cells.
Raúl Pacheco-Gómez, Rodger, A, Roper, DI, Rodger, Alison, Timothy R Dafforn, Dafforn, Tim, David I. Roper, Pacheco-Gómez, Raúl, Pacheco-Gómez Raúl, Alison Rodger, Dafforn Timothy R., Roper, David I., Pacheco-Gomez, R, Dafforn, Timothy, Rodger Alison, David I Roper, Roper David I., Timothy R. Dafforn   +17 more
core   +2 more sources

Characterisation of Bombyx mori odorant-binding proteins reveals that a general odorant-binding protein discriminates between sex pheromone components [PDF]

, 2009
In many insect species, odorant-binding proteins (OBPs) are thought to be responsible for the transport of pheromones and other semiochemicals across the sensillum lymph to the olfactory receptors (ORs) within the antennal sensilla.
Field, L.M., Pickett, J. A., Dufour, S. G. L., Zhou, J.J., Keep, N. H., Dufour, Samuel, Field, Linda M., He, X., Hooper, A.M., Hooper, A. M., Pickett, John A., Pickett, J.A., He, Xiaoli, Dufour, S., Field, L. M., Keep, Nicholas H., Robertson, G., Robertson, Giles, Zhou, J-J., Hooper, Antony M., Zhou, Jing-Jiang   +20 more
core   +1 more source

Pathogenic single nucleotide polymorphisms in RhoA gene: Insights into structural and functional impacts on RhoA-PLD1 interaction through molecular dynamics simulation

Current Research in Structural Biology
Molecular switches serve as key regulators of biological systems by acting as one of the crucial driving forces in the initiation of signal transduction pathway cascades.
Mahbub Hasan, Md. Nayem Sarker, Tazkia Jabin, Saifuddin Sarker, Shamim Ahmed, Mohammad Abdullah-Al-Shoeb, Tanvir Hossain   +6 more
doaj   +1 more source

Modulation of cell-matrix adhesions to affect mechanotransduction [PDF]

, 2010
In cultured fibroblasts three types of cell-matrix adhesion with specific cellular localization and protein composition can be distinguished: focal complexes, focal adhesions and fibrillar adhesions.
Lutz, Roman
core   +1 more source

Isolation and Imaging of His- and RFP-tagged Amyloid-like Proteins from Caenorhabditis elegans by TEM and SIM

Bio-Protocol, 2019
In our recently published paper, we highlight that during normal aging of C. elegans age-dependent aggregates of proteins form and lead to functional decline of tissues. The protocol described here details the isolation of two proteins from C. elegans in
Amberley Stephens, Meng Lu, Gabriele Kaminski Schierle   +2 more
doaj   +1 more source

The GTP-binding protein RhoA localizes to the cortical granules of Strongylocentrotus purpuratus sea urchin egg and is secreted during fertilization

European Journal of Cell Biology, 2000
The sea urchin egg has thousands of secretory vesicles known as cortical granules. Upon fertilization, these vesicles undergo a Ca2+-dependent exocytosis. G-protein-linked mechanisms may take place during the egg activation. In somatic cells from mammals, GTP-binding proteins of the Rho family regulate a number of cellular processes, including ...
P, Cuéllar-Mata, G, Martínez-Cadena, J, López-Godínez, A, Obregón, J, García-Soto   +4 more
openaire   +2 more sources

Guanosine nucleotides regulate B2 kinin receptor affinity of agonists but not of antagonists: Discussion of a model proposing receptor precoupling to G protein [PDF]

, 2000
The effect of nucleotides on binding of the B2 kinin (BK) receptor agonist {[}H-3]BK and the antagonist {[}H-3]NPC17731 to particulate fractions of human foreskin fibroblasts was studied.
Er Faussner, Faussner, Alexander, Adelbert A. Roscher, Roscher, Adelbert A.   +3 more
core   +1 more source

Paracrine signalling of AGR2 stimulates RhoA function in fibroblasts and modulates cell elongation and migration

Cell Adhesion & Migration, 2019
The most prominent cancer-associated fibroblasts (CAFs) in tumor stroma is known to form a protective structure to support tumor growth. Anterior gradient-2 (AGR2), a tumor secretory protein is believed to play a pivotal role during tumor ...
Hitesh Bhagavanbhai Mangukiya, Hema Negi, Siva Bharath Merugu, Qudsia Sehar, Dhahiri Saidi Mashausi, Fakhar-Un-Nisa Yunus, Zhenghua Wu, Dawei Li   +7 more
doaj   +1 more source