Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee +11 more
wiley +1 more source
Photocatalytic performance and mechanism of oxygen-doped g-C<sub>3</sub>N<sub>4</sub> and photoactivated peroxymonosulfate on rhodamine B. [PDF]
Liu X, Yang W, Peng H, Meng L, Zhao S.
europepmc +1 more source
In this study, a MXene‐based V4C3 nanoplatform, VARH, was constructed, which achieved a photothermal conversion efficiency of 44.21% in the NIR‐II window. This platform integrated photothermal therapy, chemodynamic therapy, and thermodynamic therapy with CRISPR/Cas9‐mediated heat shock protein 90 knock‐out technology.
Zi‐Jian Huang +8 more
wiley +1 more source
β-Cyclodextrin-Grafted Polypyrrole-Rhodamine B Nanoplatforms for Drug Delivery and Image-Guided Photothermal Therapy In Vitro. [PDF]
Hong S +6 more
europepmc +1 more source
An mRNA‐liposome vaccine via dissolving microneedles (ML‐DMN) enables efficient skin‐targeted delivery while preserving mRNA integrity and allowing sustained antigen expression. Unlike intramuscular (IM) injection, ML‐DMN engages skin‐resident immune cells, activates antigen‐presenting cells (APCs), and induces strong T cell and cytokine responses at ...
Jeehye Nam +9 more
wiley +1 more source
La-Doped ZnO/SBA-15 for Rapid and Recyclable Photodegradation of Rhodamine B Under Visible Light. [PDF]
Zhou Z, Yang W, Zhong J, Peng H, Zhao S.
europepmc +1 more source
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo +9 more
wiley +1 more source
Visible-Light-Triggered and Rhodamine B-Catalyzed Thiolation of Bromoalkynes: Accessing Alkynyl Thioethers. [PDF]
Bai R, Chiu YL, Karmakar I, Lee CF.
europepmc +1 more source
Erasable FAP Targeted Spray‐On Probe for Fluorescence‐Guided Surgery
We present the first erasable spray‐on probe for fluorescence‐guided surgery. Following topical delivery, FAP‐FLASH550 targets fibroblast activation protein–expressing stromal cells, delineating tumor margins with high tumor‐to‐background ratios. A 365 nm UV light pulse rapidly erases fluorescent signals through triazene photodegradation and subsequent
Zachary Rabinowitz +2 more
wiley +1 more source
MoS<sub>2</sub>/MXene composite material for high-performance removal of Rhodamine B dye: synthesis and application. [PDF]
Patel R +7 more
europepmc +1 more source

