Results 61 to 70 of about 6,015 (201)

Cyanide Beyond Toxicity: A Systematic Review of Its Effects on Vascular Function

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.
ABSTRACT Cyanide is widely recognized for its potent toxicity, yet evidence shows that concentrations below 1 μM may enhance cytochrome c oxidase activity and have a regulatory function. Recent findings also demonstrate that mammalian cells, including endothelial cells, produce cyanide endogenously, where it can modulate mitochondrial bioenergetics ...
Elif Alan‐Albayrak, Ulf Simonsen
wiley   +1 more source

The refolding of recombinant human liver methylmalonyl-CoA mutase from inclusion bodies produced in Escherichia coli : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]

, 1998
Human methylmalonyl-CoA mutase (hMCM) is an adenosylcobalamin-dependent enzyme that catalyses the structural rearrangement of (R)-methylmalonyl-CoA to succinyl-CoA as pan of the catabolism of the branched chain amino acids valine, leucine and isoleucine,
Hayes, Michelle Marie
core  

Effect of 3‐mercaptopyruvate sulfurtransferase (3‐MST) inhibitors on contractile responses in porcine coronary artery

British Journal of Pharmacology, Volume 182, Issue 22, Page 5453-5468, November 2025.
Background and Purpose Hydrogen sulphide (H2S) is synthesised endogenously through cystathionine β‐synthase (CBS), cystathionine γ‐lyase (CSE) and 3‐mercaptopyruvate sulfurtransferase (3‐MST). Although exogenous H2S is known to produce vasodilatation, the vascular effect of H2S produced through 3‐MST is unknown. In this study, we demonstrate the effect
Maha Almaheize, Sahar Alharthi, Patricia Hemp, Jennifer Mattos, Marcus van Leer, Michael Garle, Stephen Alexander, Richard Roberts   +7 more
wiley   +1 more source

In Hyphomicrobium denitrificans Two Related Sulfane‐Sulfur Responsive Transcriptional Repressors Regulate Thiosulfate Oxidation and Have a Deep Impact on Nitrate Respiration and Anaerobic Biosyntheses

Molecular Microbiology, Volume 124, Issue 3, Page 204-220, September 2025.
In Hyphomicrobium denitrificans, the use of thiosulfate as a supplemental electron donor is regulated by two homologous sulfane‐sulfur responsive ArsR‐type transcriptional repressors, sHdrR and SoxR, that act cooperatively. Remarkably, the regulation by sHdrR/SoxR extends far beyond sulfur oxidation and deeply affects anaerobic metabolism, particularly
Jingjing Li, Nora E. Schmitte, Kaya Törkel, Christiane Dahl   +3 more
wiley   +1 more source

Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy [PDF]

, 2011
Natural organosulfur compounds (OSCs) have been shown to have chemopreventive effects and to suppress the proliferation of tumor cells in vitro through the induction of apoptosis.
Melino, S, Paci, M, Sabelli, R
core   +1 more source

Potential Mechanism of Detoxification of Cyanide Compounds by Gut Microbiomes of Bamboo-Eating Pandas

mSphere, 2018
Gut microbes can enhance the ability of hosts to consume secondary plant compounds and, therefore, expand the dietary niche breadth of mammalian herbivores.
Lifeng Zhu, Zhisong Yang, Ran Yao, Liangliang Xu, Hua Chen, Xiaodong Gu, Tonggui Wu, Xuyu Yang   +7 more
doaj   +1 more source

New Insights Into Acidithiobacillus thiooxidans Sulfur Metabolism Through Coupled Gene Expression, Solution Chemistry, Microscopy, and Spectroscopy Analyses

Frontiers in Microbiology, 2020
Here, we experimentally expand understanding of the reactions and enzymes involved in Acidithiobacillus thiooxidans ATCC 19377 S0 and S2⁢O32- metabolism by developing models that integrate gene expression analyzed by RNA-Seq, solution sulfur speciation ...
David Camacho, Rodolfo Frazao, Aurélien Fouillen, Aurélien Fouillen, Antonio Nanci, Antonio Nanci, B. Franz Lang, Simon C. Apte, Christian Baron, Lesley A. Warren, Lesley A. Warren   +10 more
doaj   +1 more source

Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
Cyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Vik S. Bebarta, Anjali K. Nath
wiley   +1 more source

Solvent content of protein crystals from diffraction intensities by Independent Component Analysis [PDF]

, 2003
An analysis of the protein content of several crystal forms of proteins has been performed. We apply a new numerical technique, the Independent Component Analysis (ICA), to determine the volume fraction of the asymmetric unit occupied by the protein ...
A. Lamura, Authier, Cedergren-Zeppezauer, Comon, Cover, D. Siliqi, Dauter, Dauter, G. Nico, Giacovazzo, Glover, Hecht, Hecht, Hofmann, Huber, Hyvärinen, Hyvärinen, Hyvärinen, Jiang, Jones, Jutten, Kantardjeff, Kostrewa, Kostrewa, Massimo Ladisa, Matak-Vinkovic, Mattevi, Matthews, Moews, Moore, Morris, Papoulis, Spallarossa, Toro, Urzhumtsev   +34 more
core   +1 more source

Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases

Microbiology and Immunology, Volume 69, Issue 4, Page 191-202, April 2025.
ABSTRACT Supersulfides are molecular species characterized by catenated sulfur moieties, including low‐molecular‐weight and protein‐bound supersulfides. Emerging evidence suggests that these molecules, abundantly present in diverse organisms, play essential roles far beyond their chemical properties, such as functions in energy metabolism, protein ...
Tianli Zhang, Touya Toyomoto, Tomohiro Sawa, Takaaki Akaike, Tetsuro Matsunaga   +4 more
wiley   +1 more source