Results 111 to 120 of about 69,355 (271)

dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors

eLife, 2015
In eukaryotes, most integral membrane proteins are synthesized, integrated into the membrane, and folded properly in the endoplasmic reticulum (ER).
Takunori Satoh, Aya Ohba, Ziguang Liu, Tsuyoshi Inagaki, Akiko K Satoh   +4 more
doaj   +1 more source

Pinopsin Regulates Melatonin Production and Daily Locomotor Activity: Functional Insights From Gene‐Edited Xenopus Tadpoles

Journal of Pineal Research, Volume 78, Issue 2, March 2026.
ABSTRACT Circadian rhythm alignment depends on environmental light detection via opsins. Pinopsin, originally identified in the pineal organ of birds and later in amphibian pineal complex and eyes, may play a role in this process, though its function has not been genetically tested.
Neda Heshami, Ricardo D. Romero, Flavio S. J. de Souza, Gabriel E. Bertolesi, Sarah McFarlane   +4 more
wiley   +1 more source

Circadian rhythms in the Drosophila eye may regulate adaptation of vision to light intensity

Frontiers in Neuroscience
The sensitivity of the eye at night would lead to complete saturation of the eye during the day. Therefore, the sensitivity of the eye must be down-regulated during the day to maintain visual acuity.
Richard Brent Nolan, Jin-Yuan Fan, Jeffrey L. Price   +2 more
doaj   +1 more source

Mutant dominant-negative rhodopsin∆I256 causes protein aggregates degraded via ERAD and prevents normal rhodopsin from proper membrane trafficking

Frontiers in Molecular Biosciences
Dominant mutations in the rhodopsin gene (Rho) contribute to 25% of autosomal dominant retinitis pigmentosa (adRP), characterized by photoreceptor loss and progressive blindness. One such mutation, Rho∆I256, carries a 3-bp deletion, resulting in the loss
Bowen Cao, Bowen Cao, Johanna Valentina Dahlen, Merve Sen, Merve Sen, Tina Beyer, Tobias Leonhard, Ellen Kilger, Blanca Arango-Gonzalez, Marius Ueffing   +9 more
doaj   +1 more source

Optogenetic Vision Restoration Using Rhodopsin for Enhanced Sensitivity [PDF]

, 2015
Benjamin M. Gaub, Michael H. Berry, Amy Holt, Ehud Y. Isacoff, John G. Flannery   +4 more
openalex   +1 more source

Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings, Serbülent Ünsal, Mathieu Rappas, Matthew Barnes, Maria Waldhoer, Ben Holland, Martin Culka   +6 more
wiley   +1 more source

Shine Amidst Darkness—A Case of Oguchi Disease

TNOA Journal of Ophthalmic Science and Research
An 11-year-old boy presented with complaints of defective night vision. Visual acuity was 6/6 in both eyes. The fundus showed a golden-to-grey discoloration in light and on dark adaptation, the fundus reverted to its normal appearance demonstrating the ...
R Padmapriya, Fathima Fahima Akbar
doaj   +1 more source

Photoreversal of Rhodopsin Bleaching [PDF]

, 1964
Theodore P. Williams
openalex   +1 more source

MSC‐Derived Exosomal lnc‐AGT‐3: A Novel Anti‐Angiogenic Target in Age‐Related Macular Degeneration Through p53 Signaling Pathway

Aging Cell, Volume 25, Issue 2, February 2026.
MSC‐derived exosomes deliver lnc‐AGT‐3 to vascular endothelial cells, where it binds hnRNP K in the nucleus. This interaction inhibits p53 ubiquitination, enhancing p53 stabilization and transcriptional activation of anti‐angiogenic targets TSP1. Consequently, p53‐mediated signaling is potentiated, effectively suppressing choroidal neovascularization ...
Lingjie Kong, Xiaoyan Han, Siyi Qi, Duo Li, Jingyue Zhang, Linyu Zhang, Shujie Zhang, Qin Jiang, Biao Yan, Chen Zhao   +9 more
wiley   +1 more source

Localization and dimer stability of a newly identified microbial rhodopsin from a polar, non-motile green algae

BMC Research Notes, 2018
Objective The eukaryotic plasma membrane localized light-gated proton-pumping rhodopsins possesses great optogenetic applications for repolarization (silencing) of the neuronal activity simply by light illumination.
Peeyush Ranjan, Suneel Kateriya
doaj   +1 more source