Results 41 to 50 of about 69,355 (271)

Polyphenols and Visual Health: Potential Effects on Degenerative Retinal Diseases

Molecules, 2021
Dietary polyphenols are a group of natural compounds that have been proposed to have beneficial effects on human health. They were first known for their antioxidant properties, but several studies over the years have shown that these compounds can exert ...
Pol Fernandez-Gonzalez, Aina Mas-Sanchez, Pere Garriga   +2 more
doaj   +1 more source

Recoverin Regulates Light-dependent Phosphodiesterase Activity in Retinal Rods [PDF]

, 2004
The Ca2+-binding protein recoverin may regulate visual transduction in retinal rods and cones, but its functional role and mechanism of action remain controversial.
Baylor, D. A., Burns, M. E., Chen, J., Dodd, R. L., Makino, Clint L., Roca, A., Simon, M. I.   +6 more
core   +5 more sources

Prediction and classification for GPCR sequences based on ligand specific features [PDF]

, 2006
Functional identification of G-Protein Coupled Receptors (GPCRs) is one of the current focus areas of pharmaceutical research. Although thousands of GPCR sequences are known, many of them are orphan sequences (the activating ligand is unknown). Therefore,
F. Horn, G.E. Tusnády, K.R. Sreekumar, M. Bouvier, R. Karchin, S. Altshul, T. Gudermann, W. Pearson, Y. Huang   +8 more
core   +1 more source

Neuroinflammation as a Therapeutic Target in Retinitis Pigmentosa and Quercetin as Its Potential Modulator

Pharmaceutics, 2021
The retina is a multilayer neuronal tissue located in the back of the eye that transduces the environmental light into a neural impulse. Many eye diseases caused by endogenous or exogenous harm lead to retina degeneration with neuroinflammation being a ...
Joseph Thomas Ortega, Beata Jastrzebska
doaj   +1 more source

Age-related deterioration of rod vision in mice [PDF]

, 2010
Even in healthy individuals, aging leads to deterioration in visual acuity, contrast sensitivity, visual field, and dark adaptation. Little is known about the neural mechanisms that drive the age-related changes of the retina and, more specifically ...
Crouch, Rosalie K, Fan, Jie, Kefalov, Vladimir J, Kolesnikov, Alexander V   +3 more
core   +2 more sources

Rhodopsin/Lipid Hydrophobic Matching—Rhodopsin Oligomerization and Function [PDF]

Biophysical Journal, 2015
Lipid composition of the membrane and rhodopsin packing density strongly modulate the early steps of the visual response of photoreceptor membranes. In this study, lipid-order and bovine rhodopsin function in proteoliposomes composed of the sn-1 chain perdeuterated lipids 14:0d27-14:1-PC, 16:0d31-16:1-PC, 18:0d35-18:1-PC, or 20:0d39-20:1-PC at ...
Soubias, Olivier, Teague, Walter E., Hines, Kirk G., Gawrisch, Klaus   +3 more
openaire   +2 more sources

Optogenetics and deep brain stimulation neurotechnologies [PDF]

, 2015
Brain neural network is composed of densely packed, intricately wired neurons whose activity patterns ultimately give rise to every behavior, thought, or emotion that we experience. Over the past decade, a novel neurotechnique, optogenetics that combines
A Berndt, A Berndt, A Priori, AA Kuhn, AA Kuhn, AS Chuong, B Sauer, B Wingeier, BY Chow, BY Chow, C Bamann, D Luo, D Oesterhelt, D Oesterhelt, D Williams, ES Boyden, EY Uc, F Zhang, F Zhang, G Foffani, G Miesenbock, G Nagel, J Cavanaugh, J Mobley, J Volkmann, J Wells, J Wietek, JG Bernstein, JG Bernstein, JG Bernstein, JL Spudich, JL Spudich, JO Dostrovsky, JZ Tsien, L Bekar, L Madisen, LA Gunaydin, M Weinberger, M Weinberger, MC Rodriguez-Oroz, MJ Lehmkuhle, ML Welter, MM Doroudchi, O Yizhar, P Brown, P Silberstein, R Levy, R Levy, R Levy, R Waehler, S Zhao, TW Chen, VC Anderson, X Han, X Han, X Han, X Han, X Han, X Liu   +58 more
core   +2 more sources

Optogenetic manipulation of neuronal and cardiomyocyte functions in zebrafish using microbial rhodopsins and adenylyl cyclases

eLife, 2023
Even though microbial photosensitive proteins have been used for optogenetics, their use should be optimized to precisely control cell and tissue functions in vivo.
Hanako Hagio, Wataru Koyama, Shiori Hosaka, Aysenur Deniz Song, Janchiv Narantsatsral, Koji Matsuda, Takashi Shimizu, Shoko Hososhima, Satoshi P Tsunoda, Hideki Kandori, Masahiko Hibi   +10 more
doaj   +1 more source

Flotillin-associated rhodopsin (FArhodopsin), a widespread paralog of proteorhodopsin in aquatic bacteria with streamlined genomes

mSystems, 2023
Microbial rhodopsins are found more than once in a single genome (paralogs) often have different functions. We screened a large dataset of open ocean single-amplified genomes (SAGs) for co-occurrences of multiple rhodopsin genes.
Jose M. Haro-Moreno, Mario López-Pérez, Alexey Alekseev, Elizaveta Podoliak, Kirill Kovalev, Valentin Gordeliy, Ramunas Stepanauskas, Francisco Rodriguez-Valera   +7 more
doaj   +1 more source

Omega Rhodopsins: A Versatile Class of Microbial Rhodopsins

Journal of Microbiology and Biotechnology, 2020
Microbial rhodopsins are a superfamily of photoactive membrane proteins with covalently bound retinal cofactor. Isomerization of the retinal chromophore upon absorption of a photon triggers conformational changes of the protein to function as ion pumps or sensors.
Kwon, Soon-Kyeong, Jun, Sung-Hoon, Kim, Jihyun F.   +2 more
openaire   +3 more sources