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Plasmodial ortholog of Toxoplasma gondii rhoptry neck protein 3 is localized to the rhoptry body
Parasitology International, 2011The proteins in apical organelles of Plasmodium falciparum merozoite play an important role in invasion into erythrocytes. Several rhoptry neck (RON) proteins have been identified in rhoptry proteome of the closely-related apicomplexan parasite, Toxoplasma gondii. Recently, three of P. falciparum proteins orthologous to TgRON proteins, PfRON2, 4 and 5,
Daisuke, Ito +6 more
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Isolation and characterization of rhoptries of Plasmodium falciparum
Molecular and Biochemical Parasitology, 1991Rhoptries have been isolated from Plasmodium falciparum schizont-infected erythrocytes by isopycnic density centrifugation. Gradient fractions were analyzed by immunoblotting with antibodies against two polypeptides of 140 and 110 kDa, known to be components of the rhoptry. The proteins were present primarily in fractions with a density of 1.16 g ml-1.
Z, Etzion, M C, Murray, M E, Perkins
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Isolation of a Plasmodium falciparum rhoptry protein
Molecular and Biochemical Parasitology, 1985A monoclonal antibody raised against the malaria parasite Plasmodium falciparum recognised a protein of 140000 molecular weight which was synthesized during schizogony. The protein has been purified by monoclonal antibody affinity chromatography from extracts of parasitized red cells.
A A, Holder +3 more
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An antigenic complex in the rhoptries of Plasmodium falciparum
Molecular and Biochemical Parasitology, 1988A previously identified putative rhoptry antigen of Plasmodium falciparum is composed of two major components, one of 80 kDa and a doublet at 42/40 kDa. An inhibitory monoclonal antibody immunoprecipitated both the 80 kDa protein and the 42/40 kDa doublet, but immunoblotted only the 80 kDa component.
G R, Bushell +3 more
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Dissecting the apicomplexan rhoptry neck proteins
Trends in Parasitology, 2010Apicomplexan parasites possess specialized secretory organelles (rhoptries and micronemes) that release their contents during host cell invasion. Although the rhoptries were once thought to be merely a bulbous 'protein reservoir' connected to an anterior neck region, the localization of a protein specifically to the neck suggested that this region was ...
Nicholas I, Proellocks +2 more
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CLAG�9 is located in the rhoptries of Plasmodium falciparum
Parasitology Research, 2004Clag 9, a gene located on chromosome 9 of Plasmodium falciparum has previously been associated with the cytoadherence of parasitized erythrocytes to CD36. This gene is part of a multi-gene family found in all Plasmodium species studied to date.
Gardiner, Donald L. +8 more
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Rhoptry organelles of apicomplexan parasites
Parasitology Today, 1992Rhoptries are the unifying structural feature of the intracellular, opicomplexon parasites and are implicated in having a central role in host cell invasion. Ultrastructural studies of zoites of different genera suggest that the participation of rhoptries in the invasion of the respective host cells is morphologically similar.
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Experimental Parasitology, 2008
The biogenesis, organization and function of the rhoptries are not well understood. Antisera were prepared to synthetic peptides prepared as multiple antigenic peptides (MAPs) obtained from a Plasmodium yoelii merozoite rhoptry proteome analysis.
Tobili Y, Sam-Yellowe +4 more
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The biogenesis, organization and function of the rhoptries are not well understood. Antisera were prepared to synthetic peptides prepared as multiple antigenic peptides (MAPs) obtained from a Plasmodium yoelii merozoite rhoptry proteome analysis.
Tobili Y, Sam-Yellowe +4 more
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The Ins and Outs of Plasmodium Rhoptries, Focusing on the Cytosolic Side
Trends in Parasitology, 2021Parasites of the genus Plasmodium cause human and animal malaria, leading to significant health and economic impacts. A key aspect of the complex life cycle of Plasmodium parasites is the invasion of the parasite into its host cell, which is mediated by secretory organelles.
Liffner, Benjamin +4 more
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Assessing Rhoptry Secretion in T. gondii
2019Rhoptries are key secretory organelles for Toxoplasma gondii invasion. Here, we describe how to assess the ability of T. gondii tachyzoites to secrete their rhoptry contents in vitro.
Catherine, Suarez +2 more
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