Results 1 to 10 of about 16,281 (217)
The Development of Whole Sporozoite Vaccines for Plasmodium falciparum Malaria [PDF]
Frontiers in Immunology, 2018 Each year malaria kills hundreds of thousands of people and infects hundreds of millions of people despite current control measures. An effective malaria vaccine will likely be necessary to aid in malaria eradication.
Ashley M Vaughan, Anil K Ghosh
exaly +4 more sources
Rhoptry neck protein 4 plays important roles during Plasmodium sporozoite infection of the mammalian liver [PDF]
mSphere, 2023 During invasion, Plasmodium parasites secrete proteins from rhoptry and microneme apical end organelles, which have crucial roles in attaching to and invading target cells.
Minami Baba +5 more
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Novel insights from the Plasmodium falciparum sporozoite-specific proteome by probabilistic integration of 26 studies. [PDF]
PLoS Computational Biology, 2021 Plasmodium species, the causative agent of malaria, have a complex life cycle involving two hosts. The sporozoite life stage is characterized by an extended phase in the mosquito salivary glands followed by free movement and rapid invasion of hepatocytes
Lisette Meerstein-Kessel +10 more
doaj +2 more sources
Exploring the repertoire of rhomboid proteases in Cryptosporidium parvum parasite: phylogenesis, structural motifs, and cellular localization in sporozoite cells [PDF]
Frontiers in Cellular and Infection MicrobiologyCryptosporidium parvum is an apicomplexan parasite and an important pathogen of mammals and humans, which can be infected by zoonotic transmission or directly by human-to-human contact. This parasite attacks the small intestine, and the main symptom is a
Ilaria Vanni +4 more
doaj +2 more sources
Microbiology Spectrum, 2023 Plasmodium parasites are the etiological agents of malaria, a disease responsible for over half a million deaths annually. Successful completion of the parasite’s life cycle in the vertebrate host and transmission to a mosquito vector is contingent upon ...
Medard Ernest +7 more
doaj +1 more source
mSphere, 2020 In the Plasmodium life cycle, two infectious stages of parasites, merozoites and sporozoites, share rhoptry and microneme apical structures. A crucial step during merozoite invasion of erythrocytes is the discharge to the host cell membrane of some ...
Mamoru Nozaki +5 more
doaj +3 more sources
JCI Insight, 2022 Sporozoite-based approaches currently represent the most effective vaccine strategies for induction of sterile protection against Plasmodium falciparum (Pf) malaria.
Amanda Fabra-García +10 more
doaj +1 more source
eLife, 2015 In vivo imaging has revealed new details about how the malaria parasite enters the bloodstream.
Pauline Formaglio, Rogerio Amino
doaj +1 more source
Vaccines, 2023 We previously reported a protective antibody response in mice immunized with synthetic microparticle vaccines made using layer-by-layer fabrication (LbL-MP) and containing the conserved T1BT* epitopes from the P. falciparum circumsporozoite protein.
Thomas J. Powell +10 more
doaj +1 more source
Frontiers in Microbiology, 2021 Despite many decades of research to develop a malaria vaccine, only one vaccine candidate has been explored in pivotal phase III clinical trials. This candidate subunit vaccine consists of a portion of a single Plasmodium antigen, circumsporozoite ...
Calvin Hon +10 more
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