Results 1 to 10 of about 14,673 (228)

The Development of Whole Sporozoite Vaccines for Plasmodium falciparum Malaria [PDF]

Frontiers in Immunology, 2018
Each year malaria kills hundreds of thousands of people and infects hundreds of millions of people despite current control measures. An effective malaria vaccine will likely be necessary to aid in malaria eradication.
Ashley Vaughan, Anil K Ghosh, Vaughan Ashley M   +2 more
exaly   +5 more sources

Rhoptry neck protein 4 plays important roles during Plasmodium sporozoite infection of the mammalian liver [PDF]

mSphere, 2023
During invasion, Plasmodium parasites secrete proteins from rhoptry and microneme apical end organelles, which have crucial roles in attaching to and invading target cells.
Minami Baba, Mamoru Nozaki, Mayumi Tachibana, Takafumi Tsuboi, Motomi Torii, Tomoko Ishino   +5 more
doaj   +3 more sources

Novel insights from the Plasmodium falciparum sporozoite-specific proteome by probabilistic integration of 26 studies. [PDF]

PLoS Computational Biology, 2021
Plasmodium species, the causative agent of malaria, have a complex life cycle involving two hosts. The sporozoite life stage is characterized by an extended phase in the mosquito salivary glands followed by free movement and rapid invasion of hepatocytes
Lisette Meerstein-Kessel, Jeron Venhuizen, Daniel Garza, Nicholas I Proellochs, Emma J Vos, Joshua M Obiero, Philip L Felgner, Robert W Sauerwein, Marynthe Peters, Annie S P Yang, Martijn A Huynen   +10 more
doaj   +3 more sources

Exploring the repertoire of rhomboid proteases in Cryptosporidium parvum parasite: phylogenesis, structural motifs, and cellular localization in sporozoite cells [PDF]

Frontiers in Cellular and Infection Microbiology
Cryptosporidium parvum is an apicomplexan parasite and an important pathogen of mammals and humans, which can be infected by zoonotic transmission or directly by human-to-human contact. This parasite attacks the small intestine, and the main symptom is a
Ilaria Vanni, Elisabetta Pizzi, Lucia Bertuccini, Alessandra Ludovisi, Fabio Tosini   +4 more
doaj   +2 more sources

Identification of highly cross-reactive immunogens in Eimeria tenella sporozoites [PDF]

Parasite
Avian coccidiosis significantly impairs intestinal health in chickens and remains a major threat to the poultry industry worldwide. Frequent co-infections with three Eimeria species, i.e., Eimeria tenella, E. necatrix, and E.
Chen Weiyi, Han Tao, Song Feng, Zhang Haipeng, Wang Xiangqin, Gong Haiwei, Liu Liheng   +6 more
doaj   +2 more sources

Targetome Analysis of Malaria Sporozoite Transcription Factor AP2-Sp Reveals Its Role as a Master Regulator

MBio, 2023
Malaria transmission to humans begins with sporozoite infection of the liver. The elucidation of gene regulation during the sporozoite stage will promote the investigation of mechanisms of liver infection by this parasite and contribute to the ...
Tsubasa Nishi, Masao Yuda, Shiroh Iwanaga   +2 more
exaly   +3 more sources

Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission. [PDF]

Small
Engineered malaria antigens enable in vivo bioconjugation to submicron biopolymer particles in E. coli. Two antigens are co‐tethered at high density and defined stoichiometry. The resulting thermostable particles elicit strong, durable antibody and T‐cell responses, conferring robust protection and blocking mosquito transmission.
Sivakumaran N, Flores-Garcia Y, Naar CM, Chen S, Mehta M, van Leeuwen FWB, Tripathi A, Murugan R, Roestenberg M, Zavala F, Rehm BHA.   +10 more
europepmc   +2 more sources

Plasmodium falciparum Gametes and Sporozoites Hijack Plasmin and Factor H To Evade Host Complement Killing

Microbiology Spectrum, 2023
Plasmodium parasites are the etiological agents of malaria, a disease responsible for over half a million deaths annually. Successful completion of the parasite’s life cycle in the vertebrate host and transmission to a mosquito vector is contingent upon ...
Medard Ernest, Thiago F. A. Rosa, Zarna Rajeshkumar Pala, Heather M. Kudyba, Brendan Sweeney, Timo Reiss, Gabriele Pradel, Joel Vega-Rodríguez   +7 more
doaj   +1 more source

Detection of the Rhoptry Neck Protein Complex in Plasmodium Sporozoites and Its Contribution to Sporozoite Invasion of Salivary Glands

mSphere, 2020
In the Plasmodium life cycle, two infectious stages of parasites, merozoites and sporozoites, share rhoptry and microneme apical structures. A crucial step during merozoite invasion of erythrocytes is the discharge to the host cell membrane of some ...
Mamoru Nozaki, Minami Baba, Mayumi Tachibana, Naohito Tokunaga, Motomi Torii, Tomoko Ishino   +5 more
doaj   +3 more sources

Human antibodies against noncircumsporozoite proteins block Plasmodium falciparum parasite development in hepatocytes

JCI Insight, 2022
Sporozoite-based approaches currently represent the most effective vaccine strategies for induction of sterile protection against Plasmodium falciparum (Pf) malaria.
Amanda Fabra-García, Annie S.P. Yang, Marije C. Behet, Zen Yap, Youri van Waardenburg, Swarnendu Kaviraj, Kjerstin Lanke, Geert-Jan van Gemert, Matthijs M. Jore, Teun Bousema, Robert W. Sauerwein   +10 more
doaj   +1 more source