Results 21 to 30 of about 14,673 (228)

Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans

Cell Reports, 2021
Summary: The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy subjects and malaria-exposed individuals.
Henry J. Sutton, Racheal Aye, Azza H. Idris, Rachel Vistein, Eunice Nduati, Oscar Kai, Jedida Mwacharo, Xi Li, Xin Gao, T. Daniel Andrews, Marios Koutsakos, Thi H.O. Nguyen, Maxim Nekrasov, Peter Milburn, Auda Eltahla, Andrea A. Berry, Natasha KC, Sumana Chakravarty, B. Kim Lee Sim, Adam K. Wheatley, Stephen J. Kent, Stephen L. Hoffman, Kirsten E. Lyke, Philip Bejon, Fabio Luciani, Katherine Kedzierska, Robert A. Seder, Francis M. Ndungu, Ian A. Cockburn   +28 more
doaj   +1 more source

An Estimation of the Entomological Inoculation Rate for Ifakara: A Semi-Urban Area in a Region of Intense Malaria Transmission in Tanzania. [PDF]

, 2003
An entomological study on vectors of malaria and their relative contribution to Plasmodium falciparum transmission in the semi-urban area of Ifakara, south-eastern Tanzania, was conducted.
Schellenberg, D, Lengeler, C, Sousa, CA, Mshinda, H, Arez, A P, Tanner, M, Armstrong Schellenberg, J, Kihonda, J, Lines, J, Alonso, P, Sousa, C A, Lopes, D, Drakeley, C, Arez, AP   +13 more
core   +1 more source

Studies on malarial sporozoites. II. Effect of age and dosage of sporozoites on their infectiousness [PDF]

Experimental Parasitology, 1954
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/32533/1/0000635 ...
Porter, Richard J., Laird, Raymond L., Dusseau, Elizabeth M.   +2 more
openaire   +3 more sources

Susceptibility of two karyotypic forms of Anopheles aconitus (Diptera Culicidae) to Plasmodium falciparum and P. vivax [PDF]

, 2005
Four laboratory-raised colonies of two karyotypic forms of Anopheles aconitus, i.e., Form B (Chiang Mai and Phet Buri strains) and C (Chiang Mai and Mae Hong Son strains), were experimentally infected with Plasmodium falciparum and P.
Komalamisra, Narumon, Choochote, Wej, Anuluck Junkum, Suwonkerd, Wannapa, Aungkana Saejeng, Somboon, Pradya, Paul A. Bates, Wej Choochote, Narumon Komalamisra, Atchariya Jitpakdi, Wannapa Suwonkerd, Saejeng, Aungkana, Narissara Jariyapan, Jariyapan, Narissara, Bates, Paul A, Junkum, Anuluck, Jitpakdi, Atchariya, Pradya Somboon   +17 more
core   +1 more source

SBF-SEM imaging of sporozoite invasion into mosquito salivary glands. [PDF]

, 2022
A-H. SBF-SEM images of an invading untreated ama1cKO sporozoite. Panels A-C show three XY sections of the invading parasite. The sporozoite is located underneath the basal lamina (BL), and enters the cell surrounded by a vacuole (white arrowhead).
Carine Marinach (94917), Béatrice Ardin (13002102), Olivier Silvie (44628), Jean-Marc Verbavatz (667719), Rémi Le Borgne (11267664), Soumia Hamada (12908689), Priyanka Fernandes (4864351), Allon Weiner (1879345), Manon Loubens (9510496), Laetitia Vincensini (12908686), Sylvie Briquet (5916641), Bénédicte Hoareau-Coudert (9510499)   +11 more
core   +1 more source

Novel sporozoite-based ELISpot assay to assess frequency of parasite-specific B cells after vaccination with irradiated sporozoites

Malaria Journal, 2019
Background Whole parasite vaccination is an efficacious strategy to induce sterile immunity and to prevent malaria transmission. Understanding the mechanism and response of immune cells to vaccines plays a critical role in deciphering correlates of ...
Tanmaya Atre, Tanisha M. Robinson, Tatyana Savransky, Sheetij Dutta, Judith E. Epstein, Elke S. Bergmann-Leitner   +5 more
doaj   +1 more source

A First for Human Vaccinology: GMP Compliant Radiation Attenuation of Plasmodium falciparum Sporozoites for Production of a Vaccine Against Malaria

Frontiers in Immunology, 2022
Ionizing radiation (UV, X-ray and ɣ) administered at an appropriate dose to pathogenic organisms can prevent replication while preserving metabolic activity.
Eric R. James, Steve Matheny, James Overby, B. Kim Lee Sim, Abraham G. Eappen, Tao Li, Ming Lin Li, Thomas L. Richie, Sumana Chakravarty, Anusha Gunasekera, Tooba Murshedkar, Peter F. Billingsley, Stephen L. Hoffman   +12 more
doaj   +1 more source

Plasmodium berghei sporozoite invasion is blocked in vitro by sporozoite-immobilizing antibodies [PDF]

Infection and Immunity, 1986
A monoclonal antibody directed against the circumsporozoite protein on the surface of Plasmodium berghei sporozoites inhibited sporozoite motility in vitro. These immobilized sporozoites could adhere to but not invade target cultured cells. Other sporozoite-immobilizing agents also inhibited sporozoite invasion into cultured cells and did not prevent ...
M J, Stewart, R J, Nawrot, S, Schulman, J P, Vanderberg   +3 more
openaire   +2 more sources

The Plasmodium eukaryotic initiation factor-2α kinase IK2 controls the latency of sporozoites in the mosquito salivary glands [PDF]

, 2010
Sporozoites, the invasive form of malaria parasites transmitted by mosquitoes, are quiescent while in the insect salivary glands. Sporozoites only differentiate inside of the hepatocytes of the mammalian host. We show that sporozoite latency is an active
Sullivan, W. J., Sullivan, William J., Sakthivel, Ramanavelan, Fontoura, Beatriz M. A., Doerig, C., Winzeler, Elizabeth A., Tuteja, R., Roos, David S., Gueirard, Pascale, Ruth S. Nussenzweig, Tuteja, Renu, Anat Caspi, Robert Ménard, Meister, S., Ranford-Cartwright, L., Ranford-Cartwright, Lisa, Lisa Ranford-Cartwright, Nussenzweig, Victor, Ramanavelan Sakthivel, Nussenzweig, V., Ranford-Cartwright, L.C., Clare Fennell, Min Zhang, Sakthivel, R., Fennell, Clare, Nussenzweig, R. S., Sullivan, William J., Jr., Caspi, A., Beatriz M.A. Fontoura, Gueirard, P., Renu Tuteja, Menard, R., William J. Sullivan, Pascale Gueirard, Ménard, Robert, Meister, Stephan, Stephan Meister, Victor Nussenzweig, Doerig, Christian, Fontoura, B. M. A., David S. Roos, Zhang, Min, Roos, D. S., Christian Doerig, Fennell, C., Winzeler, E. A., Caspi, Anat, Zhang, M., Elizabeth A. Winzeler, Nussenzweig, Ruth S.   +49 more
core   +1 more source

Identification of Plasmodium GAPDH epitopes for generation of antibodies that inhibit malaria infection

Life Science Alliance, 2018
This study reports on the identification of two Plasmodium GAPDH epitope peptides that are responsible for sporozoite–Kupffer cell interaction and act as antigens against malaria infection.
Sung-Jae Cha, Kyle Jarrod McLean, Marcelo Jacobs-Lorena   +2 more
doaj   +1 more source