Results 11 to 20 of about 14,673 (228)

Chemoprophylaxis with sporozoite immunization in P. knowlesi rhesus monkeys confers protection and elicits sporozoite-specific memory T cells in the liver. [PDF]

PLoS ONE, 2017
Whole malaria sporozoite vaccine regimens are promising new strategies, and some candidates have demonstrated high rates of durable clinical protection associated with memory T cell responses. Little is known about the anatomical distribution of memory T
Sathit Pichyangkul, Michele D Spring, Kosol Yongvanitchit, Utaiwan Kum-Arb, Amporn Limsalakpetch, Rawiwan Im-Erbsin, Ratawan Ubalee, Pattaraporn Vanachayangkul, Edmond J Remarque, Evelina Angov, Philip L Smith, David L Saunders   +11 more
doaj   +2 more sources

Cryopreservation of Plasmodium Sporozoites

Pathogens, 2022
Malaria is a deadly disease caused by the parasite, Plasmodium, and impacts the lives of millions of people around the world. Following inoculation into mammalian hosts by infected mosquitoes, the sporozoite stage of Plasmodium undergoes obligate development in the liver before infecting erythrocytes and causing clinical malaria.
Carson Bowers, Lisa Hancox, Kristen Peissig, Justine C. Shiau, Amélie Vantaux, Benoit Witkowski, Sivchheng Phal, Steven P. Maher, John T. Harty, Dennis E. Kyle, Samarchith P. Kurup   +10 more
openaire   +3 more sources

SBF-SEM imaging of sporozoite rhoptries. [PDF]

, 2022
A-B. SBF-SEM sections of the apical end of an intracellular untreated (wt) ama1cKO sporozoite. In A, two full rhoptries are visible, indicated by white arrows. In B, a different section of the same parasite reveals an empty rhoptry (black arrow). C.
Carine Marinach (94917), Béatrice Ardin (13002102), Olivier Silvie (44628), Jean-Marc Verbavatz (667719), Rémi Le Borgne (11267664), Soumia Hamada (12908689), Priyanka Fernandes (4864351), Allon Weiner (1879345), Manon Loubens (9510496), Laetitia Vincensini (12908686), Sylvie Briquet (5916641), Bénédicte Hoareau-Coudert (9510499)   +11 more
core   +1 more source

Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivity [PDF]

, 2008
<i>Plasmodium falciparum</i> sporozoites that develop and mature inside an <i>Anopheles</i> mosquito initiate a malaria infection in humans.
Lasonder Edwin, Edwin Lasonder, Khan, Shahid M., Geert-Jan van Gemert, Mair, G. R., Gunnar R Mair, Stunnenberg Hendrik G., Waters, A.P., Mann, Matthias, van Gemert, G. J., Vermunt Adriaan M. W., Mair Gunnar R., Huynen, Martijn A., Shahid M Khan, Kroeze Hans, Stunnenberg, Hendrik G, Mair, Gunnar R., van Gemert, Geert-Jan, Janse, C., van Gemert Geert-Jan, Sauerwein, R., Stunnenberg, H. G., Janse, C.J., Mann, M., Kroeze, H., Vermunt, Adriaan M. W., Bruno G Douradinha, Luty, A., Vermunt, A.M.W., Khan, S. M., Khan, S., Vermunt, Adriaan M W, Khan, Shahid M, Chris J Janse, Sauerwein Robert W., van Gemert, G.J., Douradinha, Bruno G., Hans Kroeze, Adriaan M W Vermunt, Sauerwein, R. W., Robert W Sauerwein, Sauerwein, Robert W., Adrian J F Luty, Andrew P Waters, Kroeze, Hans, Sauerwein, Robert W, Douradinha, B.G., Luty, Adrian J F, Mann Matthias, Waters Andrew P., Lasonder, Edwin, van Noort, V., Luty, A.J.F., Sauerwein, R.W., Luty, A. J., Huynen Martijn A., Gemert, G.J.A. van, Douradinha, B. G., Mair, G.R., Douradinha, B., Khan, S.M., van Noort Vera, Huynen, Martijn A, Noort, V. van, Vera van Noort, Mair, Gunnar R, Janse, Chris J., Khan Shahid M., Stunnenberg, H., van Noort, Vera, Hendrik G Stunnenberg, Douradinha Bruno G., Lasonder, E., Janse, Chris J, Mair, G., Huynen, M., Matthias Mann, Vermunt, A. M., Waters, A. P., Janse, C. J., Waters, Andrew P, Luty Adrian J. F., van Gemert, G., Waters, A., Waters, Andrew P., Stunnenberg, H.G., Douradinha, Bruno G, Janse Chris J., Stunnenberg, Hendrik G., Luty, Adrian J. F., Huynen, M.A., Martijn A Huynen, Vermunt, A., Huynen, M. A.   +93 more
core   +1 more source

Looking for blood

eLife, 2015
In vivo imaging has revealed new details about how the malaria parasite enters the bloodstream.
Pauline Formaglio, Rogerio Amino
doaj   +1 more source

Characterization of immunoglobulin G antibodies to Plasmodium falciparum sporozoite surface antigen MB₂ in malaria exposed individuals [PDF]

, 2009
Background MB2 protein is a sporozoite surface antigen on the human malaria parasite Plasmodium falciparum. MB2 was identified by screening a P. falciparum sporozoite cDNA expression library using immune sera from a protected donor immunized via the ...
James Anthony A, de la Vega, Patricia, John, Chandy C, Thanh V Nguyen, Nguyen, Thanh V, de la Vega, P, John B Sacci, Patricia de la Vega, James, Anthony A, Kang Angray S, John Chandy C, James, AA, Nguyen, T.V., Sacci, John B, Kang, A.S., Sacci John B, de la Vega, P., Nguyen Thanh V, Anthony A James, de la Vega Patricia, John, C.C., Kang, Angray S, Angray S Kang, Sacci, J.B., Patricia Vega, Chandy C John, John, CC, Nguyen, TV, Kang, AS, Jr, SJB, James, A.A.   +30 more
core   +1 more source

Identification of the Eimeria spp. that infect Linnaeus sheep, 1758, and their morphological characteristics (Ovis aries) in Riyadh City, Saudi Arabia [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
The epidemiology of parasitic infections in sheep is a significant problem in the fields of meat production and human health. Coccidiosis in sheep is one of the major problems caused by protozoan parasites from the genus Eimeria.
A.K.A. Alosaimy, M.S. Alyousif, K.E. Ibrahim, M.M. Mares, H. Alzaylaee, H. Ahmed, M. Murshed   +6 more
doaj   +1 more source

Identification of Key Determinants of Cerebral Malaria Development and Inhibition Pathways

mBio, 2022
Cerebral malaria (CM), coma caused by Plasmodium falciparum-infected red blood cells (iRBCs), is the deadliest complication of malaria. The mechanisms that lead to CM development are incompletely understood.
Sung-Jae Cha, Xiang Yu, Brian D. Gregory, Yong Seok Lee, Tomoko Ishino, Robert O. Opoka, Chandy C. John, Marcelo Jacobs-Lorena   +7 more
doaj   +1 more source

Translational Repression in Malaria Sporozoites [PDF]

Microbial Cell, 2016
Malaria is a mosquito-borne infectious disease of humans and other animals. It is caused by the parasitic protozoan, Plasmodium. Sporozoites, the infectious form of malaria parasites, are quiescent when they remain in the salivary glands of the Anopheles mosquito until transmission into a mammalian host.
Oliver Turque, Tiffany Tsao, Thomas Li, Min Zhang   +3 more
openaire   +3 more sources

Differential evidence of natural selection on two leading sporozoite stage malaria vaccine candidate antigens. [PDF]

, 2007
Experimental malaria vaccines based on two sporozoite stage candidate antigens of Plasmodium falciparum, the circumsporozoite protein (CSP) and thrombospondin-related adhesive protein (TRAP), have undergone clinical trials of efficacy.
Sutherland, Colin J, Conway, David J, Weedall, Gareth D, Benjamin M.J. Preston, Thomas, Alan W, Alan W. Thomas, Preston, Benjamin MJ, Gareth D. Weedall, David J. Conway, Colin J. Sutherland   +9 more
core   +1 more source