Results 41 to 50 of about 14,673 (228)

Prevalence of anti-p: Falciparum sporozoite antibodies in adults in the amapa region of Brazil

Revista do Instituto de Medicina Tropical de São Paulo, 1987
17 of 20 adult sera from the Amapa region of Brazil were active in the inhibition of P. falciparum sporozoite invasion (ISI) assay which has been correlated with protective antibodies. In contrast 11 sera were positive in IFA tests and 6 were positive in
Virgílio Do Rosario, Michael R. Hollingdale   +1 more
doaj   +1 more source

Immunogenicity, Efficacy, and Safety of a Novel Synthetic Microparticle Pre-Erythrocytic Malaria Vaccine in Multiple Host Species

Vaccines, 2023
We previously reported a protective antibody response in mice immunized with synthetic microparticle vaccines made using layer-by-layer fabrication (LbL-MP) and containing the conserved T1BT* epitopes from the P. falciparum circumsporozoite protein.
Thomas J. Powell, Jie Tang, Robert Mitchell, Mary E. DeRome, Andrea Jacobs, Naveen Palath, Edwin Cardenas, Michelle Yorke, James G. Boyd, Stephen A. Kaba, Elizabeth Nardin   +10 more
doaj   +1 more source

Sporozoite malaria vaccine Where do we stand? [PDF]

, 2016
A sporozoite malaria vaccine which elicits high levels of antibodies to the circumsporozoite (CS) protein may protect part of the human population in areas of low endemicity.
V. Nussenzweig, S. Nussenzweig
core   +1 more source

Plasmodium vivax Cell Traversal Protein for Ookinetes and Sporozoites (CelTOS) Functionally Restricted Regions Are Involved in Specific Host-Pathogen Interactions

Frontiers in Cellular and Infection Microbiology, 2020
Following the injection of Plasmodium sporozoites by a female Anopheles mosquito into the dermis, they become engaged on a long journey to hepatic tissue where they must migrate through different types of cell to become established in parasitophorous ...
Gabriela Arévalo-Pinzón, Gabriela Arévalo-Pinzón, Diego Garzón-Ospina, Fredy A. Pulido, Maritza Bermúdez, Johanna Forero-Rodríguez, Xandy M. Rodríguez-Mesa, Leidy P. Reyes-Guarín, Carlos F. Suárez, Carlos F. Suárez, Manuel A. Patarroyo, Manuel A. Patarroyo   +11 more
doaj   +1 more source

Malaria parasites differentially sense environmental elasticity during transmission

EMBO Molecular Medicine, 2021
Transmission of malaria‐causing parasites to and by the mosquito relies on active parasite migration and constitutes bottlenecks in the Plasmodium life cycle.
Johanna Ripp, Jessica Kehrer, Xanthoula Smyrnakou, Nathalie Tisch, Joana Tavares, Rogerio Amino, Carmen Ruiz de Almodovar, Friedrich Frischknecht   +7 more
doaj   +1 more source

Conservation of S20 as an Ineffective and Disposable IFNγ-Inducing Determinant of Plasmodium Sporozoites Indicates Diversion of Cellular Immunity

Frontiers in Microbiology, 2021
Despite many decades of research to develop a malaria vaccine, only one vaccine candidate has been explored in pivotal phase III clinical trials. This candidate subunit vaccine consists of a portion of a single Plasmodium antigen, circumsporozoite ...
Calvin Hon, Johannes Friesen, Johannes Friesen, Alyssa Ingmundson, Alyssa Ingmundson, Diana Scheppan, Julius C. R. Hafalla, Katja Müller, Katja Müller, Kai Matuschewski, Kai Matuschewski   +10 more
doaj   +1 more source

Plasmodium Sporozoite Biology [PDF]

Cold Spring Harbor Perspectives in Medicine, 2017
Plasmodium sporozoite transmission is a critical population bottleneck in parasite life-cycle progression and, hence, a target for prophylactic drugs and vaccines. The recent progress of a candidate antisporozoite subunit vaccine formulation to licensure highlights the importance of sporozoite transmission intervention in the malaria control portfolio.
Friedrich, Frischknecht, Kai, Matuschewski   +1 more
openaire   +2 more sources

Blood-stage immunity to Plasmodium chabaudi malaria following chemoprophylaxis and sporozoite immunization

eLife, 2015
Protection against malaria in humans can be achieved by repeated exposure to infected mosquito bites during prophylactic chloroquine treatment (chemoprophylaxis and sporozoites (CPS)).
Wiebke Nahrendorf, Philip J Spence, Irene Tumwine, Prisca Lévy, William Jarra, Robert W Sauerwein, Jean Langhorne   +6 more
doaj   +1 more source

Characterization of the Theileria parva sporozoite proteome [PDF]

, 2017
East Coast fever is a lymphoproliferative disease caused by the tick-borne protozoan parasite Theileria parva. The sporozoite stage of this parasite, harboured and released from the salivary glands of the tick Rhipicephalus appendiculatus during feeding,
Nyagwange, James, Mobegi, F, Fredrick Mobegi, Kyle Tretina, Pelle, R., Tijhaar, E., Tretina, Kyle, Nene, Vishvanath, Nicola Ternette, Tijhaar, E, Nene, V., Edwin Tijhaar, Ternette, Nicola, Silva, Joana C., Roger Pelle, James Nyagwange, Ternette, N, Tijhaar, Edwin, Ternette, N., Silva, J.C., Nene, Vishvanath M., Nyagwange, J., Pelle, Roger, Nene, V, Nyagwange, J, Tretina, K, Vishvanath Nene, Joana C. Silva, Pelle, R, Tretina, K., Mobegi, Fredrick, Silva, JC   +31 more
core   +1 more source

Engineering of Genetically Arrested Parasites (GAPs) For a Precision Malaria Vaccine

Frontiers in Cellular and Infection Microbiology, 2017
Continuous stage conversion and swift changes in the antigenic repertoire in response to acquired immunity are hallmarks of complex eukaryotic pathogens, including Plasmodium species, the causative agents of malaria.
Oriana Kreutzfeld, Katja Müller, Kai Matuschewski   +2 more
doaj   +1 more source