Results 41 to 50 of about 16,281 (217)

SBF-SEM imaging of sporozoite invasion into mosquito salivary glands.

, 2022
A-H. SBF-SEM images of an invading untreated ama1cKO sporozoite. Panels A-C show three XY sections of the invading parasite. The sporozoite is located underneath the basal lamina (BL), and enters the cell surrounded by a vacuole (white arrowhead).
Carine Marinach (94917), Béatrice Ardin (13002102), Olivier Silvie (44628), Jean-Marc Verbavatz (667719), Rémi Le Borgne (11267664), Soumia Hamada (12908689), Priyanka Fernandes (4864351), Allon Weiner (1879345), Manon Loubens (9510496), Laetitia Vincensini (12908686), Sylvie Briquet (5916641), Bénédicte Hoareau-Coudert (9510499)   +11 more
core   +1 more source

The Micronemal Plasmodium Proteins P36 and P52 Act in Concert to Establish the Replication-Permissive Compartment Within Infected Hepatocytes

Frontiers in Cellular and Infection Microbiology, 2018
Within the liver, Plasmodium sporozoites traverse cells searching for a “suitable” hepatocyte, invading these cells through a process that results in the formation of a parasitophorous vacuole (PV), within which the parasite undergoes intracellular ...
Silvia A. Arredondo, Kristian E. Swearingen, Thomas Martinson, Ryan Steel, Dorender A. Dankwa, Anke Harupa, Nelly Camargo, William Betz, Vladimir Vigdorovich, Brian G. Oliver, Niwat Kangwanrangsan, Tomoko Ishino, Noah Sather, Sebastian Mikolajczak, Ashley M. Vaughan, Motomi Torii, Robert L. Moritz, Stefan H. I. Kappe   +17 more
doaj   +1 more source

A First for Human Vaccinology: GMP Compliant Radiation Attenuation of Plasmodium falciparum Sporozoites for Production of a Vaccine Against Malaria

Frontiers in Immunology, 2022
Ionizing radiation (UV, X-ray and ɣ) administered at an appropriate dose to pathogenic organisms can prevent replication while preserving metabolic activity.
Eric R. James, Steve Matheny, James Overby, B. Kim Lee Sim, Abraham G. Eappen, Tao Li, Ming Lin Li, Thomas L. Richie, Sumana Chakravarty, Anusha Gunasekera, Tooba Murshedkar, Peter F. Billingsley, Stephen L. Hoffman   +12 more
doaj   +1 more source

Effects of Vector Density on Blood Parasite Spread and Health Consequences for Avian Hosts: An Experimental Epidemiology Blueprint

Integrative Zoology, EarlyView.
In an experimental epidemiology setup, groups of pigeons were exposed to different numbers of infective malaria vectors. Vector number explained the speed of transmission, the final prevalence, and changes in host behavior. ABSTRACT Vector density plays a critical role in the transmission dynamics of vector‐borne diseases and thus in their health and ...
Nayden Chakarov, Tim Brandler, Kai Fischer, Carmen Schwietz   +3 more
wiley   +1 more source

Fusion to green fluorescent protein improves expression levels of Theileria parva sporozoite surface antigen p67 in insect cells [PDF]

, 2002
East Coast fever (ECF) is a fatal disease of cattle caused by the protozoan parasite Theileria parva. The development of a subunit vaccine, based on the sporozoite-specific surface antigen p67, has been hampered by difficulties in achieving high-level ...
Kaba, S.A., Nene, V., Musoke, A.J., Vlak, J.M., Oers, M.M., van   +4 more
core  

Sporozoite immunization schedule.

, 2013
Sporozoite immunization schedule.
Walter R. Weiss (333031), Chengyong George Jiang (333032)   +1 more
core   +1 more source

Urbanization and Vector Species Shape Avian Malaria Prevalence in Mosquitoes

Integrative Zoology, EarlyView.
Avian malaria prevalence was assessed in two mosquito species across urban and peri‐urban habitats. No infections were detected in either species in urban areas, while a 2.53% prevalence was found in the native Culex pipiens from peri‐urban sites, highlighting the influence of urbanization on parasite transmission dynamics.
Paula Parra, Jesús Veiga, Marta Garrigós, Guillermo Panisse, Mario Garrido, Josué Martínez‐de la Puente   +5 more
wiley   +1 more source

Plasmodium Sporozoite Biology [PDF]

Cold Spring Harbor Perspectives in Medicine, 2017
Plasmodium sporozoite transmission is a critical population bottleneck in parasite life-cycle progression and, hence, a target for prophylactic drugs and vaccines. The recent progress of a candidate antisporozoite subunit vaccine formulation to licensure highlights the importance of sporozoite transmission intervention in the malaria control portfolio.
Friedrich, Frischknecht, Kai, Matuschewski   +1 more
openaire   +2 more sources

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Nutrient Sensing and Growth Control in Plasmodium: Beyond mTOR Signaling

Molecular Microbiology, EarlyView.
Plasmodium parasites lack the canonical mTOR kinase and associated signaling complexes, yet retain key mTOR‐like functions. Parasite‐specific nutrient sensors, kinases, and translational regulators coordinate growth, stress adaptation, metabolic plasticity, and developmental decisions through a distributed regulatory network.
Felix Müller, Gabriele Pradel
wiley   +1 more source