Results 31 to 40 of about 16,281 (217)

Strong concordance between percent inhibition in oocyst and sporozoite intensities in a Plasmodium falciparum standard membrane-feeding assay

Parasites & Vectors, 2019
Background Effective malaria transmission-blocking vaccines (TBVs) can support malaria eradication programmes, and the standard membrane-feeding assay (SMFA) has been used as a “gold standard” assay for TBV development.
Kazutoyo Miura, Bruce J. Swihart, Bingbing Deng, Luwen Zhou, Thao P. Pham, Ababacar Diouf, Michael P. Fay, Carole A. Long   +7 more
doaj   +1 more source

Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

Nature Communications, 2019
Here, the authors report transcriptomes and proteomes of oocyst sporozoite and salivary gland sporozoite stages in rodent-infectious Plasmodium yoelii parasites and human infectious Plasmodium falciparum parasites and define two waves of translational ...
Scott E. Lindner, Kristian E. Swearingen, Melanie J. Shears, Michael P. Walker, Erin N. Vrana, Kevin J. Hart, Allen M. Minns, Photini Sinnis, Robert L. Moritz, Stefan H. I. Kappe   +9 more
doaj   +1 more source

Preservation of Coccidial Sporozoites by Freezing [PDF]

Nature, 1968
MAINTENANCE of cultures of coccidia for experimental purposes is laborious and expensive. To overcome these difficulties, we attempted to freeze and store sporozoites of Eimeria meleagrimitis Tyzzer, 1929, and E. tenella (Railliet and Lucet, 1891) Fantham, 1909, in liquid nitrogen vapour.
D J, Doran, J M, Vetterling
openaire   +2 more sources

A Novel Rhoptry Protein as Candidate Vaccine against Eimeria tenella Infection

Vaccines, 2020
Eimeria tenella (E. tenella) is a highly pathogenic and prevalent species of Eimeria that infects chickens, and it causes a considerable disease burden worldwide. The secreted proteins and surface antigens of E.
Xingju Song, Xu Yang, Taotao Zhang, Jing Liu, Qun Liu   +4 more
doaj   +1 more source

The Plasmodium eukaryotic initiation factor-2α kinase IK2 controls the latency of sporozoites in the mosquito salivary glands [PDF]

, 2010
Sporozoites, the invasive form of malaria parasites transmitted by mosquitoes, are quiescent while in the insect salivary glands. Sporozoites only differentiate inside of the hepatocytes of the mammalian host. We show that sporozoite latency is an active
Sullivan, W. J., Sullivan, William J., Sakthivel, Ramanavelan, Fontoura, Beatriz M. A., Doerig, C., Winzeler, Elizabeth A., Tuteja, R., Roos, David S., Gueirard, Pascale, Ruth S. Nussenzweig, Tuteja, Renu, Anat Caspi, Robert Ménard, Meister, S., Ranford-Cartwright, L., Ranford-Cartwright, Lisa, Lisa Ranford-Cartwright, Nussenzweig, Victor, Ramanavelan Sakthivel, Nussenzweig, V., Ranford-Cartwright, L.C., Clare Fennell, Min Zhang, Sakthivel, R., Fennell, Clare, Nussenzweig, R. S., Sullivan, William J., Jr., Caspi, A., Beatriz M.A. Fontoura, Gueirard, P., Renu Tuteja, Menard, R., William J. Sullivan, Pascale Gueirard, Ménard, Robert, Meister, Stephan, Stephan Meister, Victor Nussenzweig, Doerig, Christian, Fontoura, B. M. A., David S. Roos, Zhang, Min, Roos, D. S., Christian Doerig, Fennell, C., Winzeler, E. A., Caspi, Anat, Zhang, M., Elizabeth A. Winzeler, Nussenzweig, Ruth S.   +49 more
core   +1 more source

Identification of highly cross-reactive immunogens in Eimeria tenella sporozoites

Parasite
Avian coccidiosis significantly impairs intestinal health in chickens and remains a major threat to the poultry industry worldwide. Frequent co-infections with three Eimeria species, i.e., Eimeria tenella, E. necatrix, and E.
Chen Weiyi, Han Tao, Song Feng, Zhang Haipeng, Wang Xiangqin, Gong Haiwei, Liu Liheng   +6 more
doaj   +1 more source

Identification of Key Determinants of Cerebral Malaria Development and Inhibition Pathways

mBio, 2022
Cerebral malaria (CM), coma caused by Plasmodium falciparum-infected red blood cells (iRBCs), is the deadliest complication of malaria. The mechanisms that lead to CM development are incompletely understood.
Sung-Jae Cha, Xiang Yu, Brian D. Gregory, Yong Seok Lee, Tomoko Ishino, Robert O. Opoka, Chandy C. John, Marcelo Jacobs-Lorena   +7 more
doaj   +1 more source

Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans

Cell Reports, 2021
Summary: The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy subjects and malaria-exposed individuals.
Henry J. Sutton, Racheal Aye, Azza H. Idris, Rachel Vistein, Eunice Nduati, Oscar Kai, Jedida Mwacharo, Xi Li, Xin Gao, T. Daniel Andrews, Marios Koutsakos, Thi H.O. Nguyen, Maxim Nekrasov, Peter Milburn, Auda Eltahla, Andrea A. Berry, Natasha KC, Sumana Chakravarty, B. Kim Lee Sim, Adam K. Wheatley, Stephen J. Kent, Stephen L. Hoffman, Kirsten E. Lyke, Philip Bejon, Fabio Luciani, Katherine Kedzierska, Robert A. Seder, Francis M. Ndungu, Ian A. Cockburn   +28 more
doaj   +1 more source

Killing of Cryptosporidium sporozoites by Lactoferrin [PDF]

The American Journal of Tropical Medicine and Hygiene, 2017
Intestinal infection caused by Cryptosporidium is a major contributor to diarrhea morbidity and mortality in young children around the world. Current treatments for children suffering from cryptosporidiosis are suboptimal. Lactoferrin is a glycoprotein found in breast milk.
Paredes, Jose Luis, Sparks, Hayley, White, A. Clinton, Martinez-Traverso, Griselle, Ochoa Woodell, Theresa Jean, Castellanos-González, Alejandro   +5 more
openaire   +3 more sources

Transition of plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein pumilio [PDF]

, 2011
Many eukaryotic developmental and cell fate decisions that are effected post-transcriptionally involve RNA binding proteins as regulators of translation of key mRNAs.
Gunnar R Mair, Waters, Andrew, Waters, A.P., Prudêncio, M., Joanna Braks, Braks, Joanna, Mair Gunnar R., Braks, J., Theresa Feltwell, Prudêncio, Miguel, Mair, Gunnar R., Gomes-Santos, Carina S. S., Feltwell Theresa, Pain, A., Janse, C., Mota, Maria M., Mota, M.M., Céline Carret, Carret, Céline, Shahid Khan, Gomes, Ana Rita, Khan, S., Miguel Prudêncio, Ana Rita Gomes, Carina S S Gomes-Santos, Mota Maria M., Khan Shahid, Carina S. S. Gomes-Santos, Prudêncio Miguel, Maria M. Mota, Waters Andrew, Gomes-Santos Carina S. S., Gomes-Santos, C.S.S., Gomes, A.R., Mair, G.R., Andrew Waters, Gunnar R. Mair, Gomes Ana Rita, Feltwell, T., Carret Céline, Pain, Arnab, Khan, Shahid, Janse, Chris, Chris Janse, Maria M Mota, Carret, C., Janse Chris, Waters, A., Arnab Pain, Pain Arnab, Feltwell, Theresa, Braks Joanna   +51 more
core   +1 more source