Results 171 to 180 of about 5,406 (212)

Plasmodium rhoptry proteins: why order is important

Trends in Parasitology, 2013
Apicomplexan parasites, including the Plasmodium species that cause malaria, contain three unusual apical secretory organelles (micronemes, rhoptries, and dense granules) that are required for the infection of new host cells. Because of their specialized nature, the majority of proteins secreted from these organelles are unique to Apicomplexans and are
Natalie A, Counihan, Ming, Kalanon, Ross L, Coppel, Tania F, de Koning-Ward   +3 more
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Processing of Toxoplasma ROP1 protein in nascent rhoptries

Molecular and Biochemical Parasitology, 1998
Secretion in the obligate intracellular parasite, Toxoplasma gondii, occurs through a number of regulated compartments. Among these are the apical organelles known as rhoptries which release their contents as part of the invasion process. We are interested in the processing, targeting and ultimate function of rhoptry proteins (and have focused our ...
D, Soldati, A, Lassen, J F, Dubremetz, J C, Boothroyd   +3 more
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Kiss and spit: the dual roles of Toxoplasma rhoptries

Nature Reviews Microbiology, 2008
Toxoplasma gondii is a single-celled, eukaryotic parasite that can only reproduce inside a host cell. Upon entry, this Apicomplexan parasite co-opts host functions for its own purposes. An unusual set of apical organelles, named rhoptries, contain some of the machinery that is used by T. gondii both for invasion and to commandeer host functions.
Boothroyd, John C, Dubremetz, Jean-Francois   +1 more
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Primary structure of aPlasmodium falciparum rhoptry antigen

Molecular and Biochemical Parasitology, 1991
The high-molecular-weight rhoptry complex of Plasmodium falciparum consists of 3 non-covalently associated polypeptides of 150, 135 and 105 kDa. We present the complete nucleotide sequence of the 105-kDa (RhopH3) component of this complex derived from analysis of genomic and cDNA clones. The genomic structure is unusually complex for P.
H J, Brown, R L, Coppel
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Characterization of a family of rhoptry proteins ofToxoplasma gondii

Molecular and Biochemical Parasitology, 1988
A monoclonal antibody (McAb 4A7) raised against a rhoptry enriched subcellular fraction of Toxoplasma gondii tachyzoites reacted in immunofluorescence studies with rod-like organelles located in the anterior part of the organisms and gave specific labeling of rhoptries in immunoelectron microscopy.
A, Sadak, Z, Taghy, B, Fortier, J F, Dubremetz   +3 more
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Plasmodium RON12 localizes to the rhoptry body in sporozoites

Parasitology International, 2019
Invasion of host cells by apicomplexan parasites is mediated by proteins released from microneme, rhoptry, and dense granule secretory organelles located at the apical end of parasite invasive forms. Microneme secreted proteins establish interactions with host cell receptors and induce exocytosis of the rhoptry organelle.
Yuki, Oda-Yokouchi, Mayumi, Tachibana, Hideyuki, Iriko, Motomi, Torii, Tomoko, Ishino, Takafumi, Tsuboi   +5 more
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Analysis of the processing of Plasmodium falciparum rhoptry-associated protein 1 and localization of Pr86 to schizont rhoptries and p67 to free merozoites

Molecular and Biochemical Parasitology, 1998
The processing and localization of Plasmodium falciparum rhoptry-associated protein 1 (RAP-1) products were examined using polyclonal and monoclonal antibodies raised to a recombinant protein containing residues 1-294 of RAP-1. Immunoblot and epitope mapping results with antibodies that selectively bound epitopes in the RAP-1 products Pr86, p82, and ...
R F, Howard, D L, Narum, M, Blackman, J, Thurman   +3 more
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The pro region of Toxoplasma ROP1 is a rhoptry-targeting signal

International Journal for Parasitology, 2001
The rhoptries of Toxoplasma gondii are regulated secretory organelles involved in the invasion of host cells. Rhoptry proteins are synthesised as pre-pro-proteins that are processed first to pro-proteins upon entrance into the secretory pathway, then processed again to their mature forms late in the secretory pathway.
P J, Bradley, J C, Boothroyd
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Erythrocyte invasion: Vocabulary and grammar of the Plasmodium rhoptry

Parasitology International, 2007
Malaria is a dangerous infectious disease caused by obligate intracellular protozoan Plasmodium parasites. In the vertebrate host, erythrocyte recognition and establishment of a nascent parasitophorous vacuole are essential processes, and are largely achieved using molecules located in the microorganelles of the invasive-stage parasites.
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Toxoplasma gondii: isolation of tachyzoites rhoptries and incorporation into Iscom

Experimental Parasitology, 2004
Rhoptries have been isolated from Toxoplasma gondii tachyzoites by subcellular fractionation in isopynic density sucrose gradient. Five bands were observed, and transmission electron microscopy of these indicated that rhoptries were in band 3. This band had a density of 1.17 g/cm(3). Fraction 1 had membrane structures of the parasite.
Garcia, J. L., Gennari, S. M., Navarro, I. T., Machado, R. Z., Sinhorini, L. L.   +4 more
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