Results 31 to 40 of about 185,351 (165)
Modernising the Ribo-Seq approach: a new gold standard
Controlled AccessRibosome profiling (Ribo-Seq) provides a genome-wide snapshot of protein synthesis by identifying the locations of translating ribosomes at single-nucleotide resolution via deep sequencing of ribosome protected mRNA fragments.
O'Connell, Aoife Myra
core +2 more sources
Variational inference for detecting differential translation in ribosome profiling studies
Frontiers in Genetics, 2023 Translational efficiency change is an important mechanism for regulating protein synthesis. Experiments with paired ribosome profiling (Ribo-seq) and mRNA-sequencing (RNA-seq) allow the study of translational efficiency by simultaneously quantifying the ...
David C. Walker +5 more
doaj +1 more source
Comparison of software packages for detecting unannotated translated small open reading frames by Ribo-seq. [PDF]
Brief BioinformAccurate and comprehensive annotation of microprotein-coding small open reading frames (smORFs) is critical to our understanding of normal physiology and disease.
Tong G, Hah N, Martinez TF.
europepmc +2 more sources
Improved Ribo-seq enables identification of cryptic translation events. [PDF]
Nat Methods, 2018 Ribosome profiling has been used to predict thousands of short open reading frames (sORFs) in eukaryotic cells, but it suffers from substantial levels of noise. PRICE (https://github.com/erhard-lab/price) is a computational method that models experimental noise to enable researchers to accurately resolve overlapping sORFs and noncanonical translation ...
Erhard F +8 more
europepmc +5 more sources
Comparison of software packages for detecting unannotated translated small open reading frames by Ribo-seq [PDF]
, 2023 Accurate and comprehensive annotation of microprotein-coding small open reading frames (smORFs) is critical to our understanding of normal physiology and disease.
Tong, Gregory +2 more
core +1 more source
A custom library construction method for super-resolution ribosome profiling in Arabidopsis
Plant Methods, 2022 Background Ribosome profiling, also known as Ribo-seq, is a powerful technique to study genome-wide mRNA translation. It reveals the precise positions and quantification of ribosomes on mRNAs through deep sequencing of ribosome footprints.
Hsin-Yen Larry Wu, Polly Yingshan Hsu
doaj +1 more source
, 2022 Processed ribo-seq data from several public datasets, in bigwig format. List of dataset is as follow:├── Bazin_2017/│ ├── Bazin_wt_R1.bw│ └── Bazin_wt_R2.bw├── Hsu_2016/│ ├── Hsu_root_A.bw│ ├── Hsu_root_B.bw│ ├── Hsu_root_C.bw│ ├── Hsu_root_D.
Axel Thieffry (7510553)
core +1 more source
Accurate detection of short and long active ORFs using Ribo-seq data. [PDF]
Bioinformatics, 2020 Abstract Motivation Ribo-seq, a technique for deep-sequencing ribosome-protected mRNA fragments, has enabled transcriptome-wide monitoring of translation in vivo. It has opened avenues for re-evaluating the coding potential of open reading frames (ORFs), including many short ORFs that were previously ...
Choudhary S, Li W, D Smith A.
europepmc +5 more sources
Frontiers in Oncology, 2021 Cutaneous melanoma (CMM) is a skin tumor with a high degree of malignancy. BRAF resistance imposes great difficulty to the treatment of CMM, and partially contributes to the poor prognosis of CMM.
Tianhong Wei, Lan Li, Zhiyou He
doaj +1 more source