Results 91 to 100 of about 449,947 (286)

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Adaptive regulation of riboflavin transport in heart: effect of dietary riboflavin deficiency in cardiovascular pathogenesis [PDF]

, 2018
Deficiency or defective transport of riboflavin (RF) is known to cause neurological disorders, cataract, cardiovascular anomalies, and various cancers by altering the biochemical pathways.
Manole, A, Houlden, H, Udhayabanu, T, Ashokkumar, B, Karthi, S, Varalakshmi, P, Mahesh, A   +6 more
core   +1 more source

Revitalising Riboflavin: Unveiling Its Timeless Significance in Human Physiology and Health

Foods
Since the early twentieth century, research on vitamins has revealed their therapeutic potential beyond their role as essential micronutrients. Riboflavin, known as vitamin B2, stands out for its unique characteristics.
M. Ângela Aragão, Lara Pires, Celestino Santos-Buelga, Lillian Barros, Ricardo C. Calhelha   +4 more
doaj   +1 more source

A juvenile ALS‐like phenotype dramatically improved after high‐dose riboflavin treatment

Annals of Clinical and Translational Neurology, 2020
Riboflavin transporter deficiency (RTD) was recently characterized as a cause of genetic recessive childhood‐onset motor neuron disease (MND) with hearing loss, formerly described as Brown‐Vialetto‐Van‐Lear syndrome.
Christophe Carreau, Timothée Lenglet, Isabelle Mosnier, Ghizlene Lahlou, Guillaume Fargeot, Nicolas Weiss, Sophie Demeret, François Salachas, Alice Veauville‐Merllié, Cécile Acquaviva, Yann Nadjar   +10 more
doaj   +1 more source

Riboflavin deficiency and iron absorption in adult Gambian men

, 1992
Iron absorption from 3.38 mg 58Fe was measured in riboflavin-deficient Gambian men with haemoglobin (Hb) less than 11.5 g/dl before and after oral riboflavin therapy, and the results compared with a group not receiving riboflavin.
Downes, R, Fairweather-Tait, S J, Powers, H J, Whitehead, J, Minski, M J   +4 more
core   +1 more source

Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source

Determinants of Riboflavin Responsiveness in Multiple Acyl-CoA Dehydrogenase Deficiency

, 2019
Background: Multiple acyl-CoA dehydrogenase (MADD) deficiency, which is a rare metabolic disorder involving electron transport flavoproteins, has a wide array of clinical phenotypes.
DURSUN, ALİ, YILDIZ, YILMAZ, SİVRİ, HATİCE SERAP, TOKATLI, AYŞEGÜL, AKÇÖREN, ZUHAL, COŞKUN, TURGAY, Haliloglu, Goknur, Topaloglu, Haluk, TALİM, BERİL   +8 more
core   +1 more source

Interactions and potential implications of Plasmodium falciparum-hookworm coinfection in different age groups in south-central Côte d'Ivoire [PDF]

, 2012
BACKGROUND: Given the widespread distribution of Plasmodium and helminth infections, and similarities of ecological requirements for disease transmission, coinfection is a common phenomenon in sub-Saharan Africa and elsewhere in the tropics. Interactions
Richard F Hurrell, Aurélie A Righetti, N'Goran Eliézer K., Righetti, Aurélie A., N'Goran, E. K., Ahou-Yah G Koua, Utzinger, Jürg, Glinz, D., Koua Ahou-Yah G., Hurrell Richard F., Wegmüller, Rita, Rita Wegmüller, Utzinger Jürg, Dominik Glinz, Righetti Aurélie A., Adiossan Lukas G., Jürg Utzinger, Niamké, S., Adiossan, L. G., Lukas G Adiossan, Righetti, A. A., Utzinger, J., Koua, Ahou-Yah G., Niamké Sébastien, Adiossan, Lukas G., Niamké, Sébastien, Koua, A. Y. G., Hurrell, R. F., Glinz Dominik, Glinz, Dominik, Wegmüller Rita, Eliézer K N'Goran, N'Goran, Eliézer K., Sébastien Niamké, Hurrell, Richard F., Wegmüller, R.   +35 more
core   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Identification of Riboflavin Metabolism Pathway in HepG2 Cells Expressing Genotype IV Swine Hepatitis E Virus ORF3 Protein

Veterinary Sciences
(1) Background: Hepatitis E (HE) is a novel zoonotic disease caused by hepatitis E virus (HEV). In particular, swine hepatitis E virus (SHEV) genotype IV is one of the main genotypes that infect humans.
Jing Tu, Shengping Wu, Lingjie Wang, Chi Meng, Gengxu Zhou, Jianhua Guo, Jixiang Li, Liting Cao, Zhenhui Song, Hanwei Jiao   +9 more
doaj   +1 more source