Results 101 to 110 of about 433,059 (284)
Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery
Aggregate, EarlyView.This review highlights recent progress in cell membrane‐coated lipid nanoparticles (CMC‐LNPs), focusing on their design, preparation methods, functional integration, and biomedical applications. It discusses various types of LNPs and coating strategies, characterization techniques, therapeutic functions, and applications.
Moataz B. Zewail +5 more
wiley +1 more source
A hybrid of bovine pancreatic ribonuclease and human angiogenin: an external loop as a module controlling substrate specificity? [PDF]
, 2017 A comparison of the sequences of three homologous ribonucleases (RNase A, angiogenin and bovine seminal RNase) identifies three surface loops that are highly variable between the three proteins.
Allemann, Rudolf K. +2 more
core
Elucidation of the disulfide folding pathway of hirudin by a topology-based approach [PDF]
, 2003 A theoretical model for the folding of proteins containing disulfide bonds is introduced. The model exploits the knowledge of the native state to favour the progressive establishment of native interactions.
De Filippis, V. +3 more
core +2 more sources
Dependence of ethanol effects on protein charges [PDF]
, 2014 Ethanol is used as a conventional disinfectant solution. It is highly effective against enveloped viruses due to its effects on virus membranes. It also confers inactivation of non-enveloped viruses, which can be ascribed to conformational changes or ...
Arakawa Tsutomu +3 more
core +1 more source
Elevated serum ribonuclease in patients with pancreatic cancer.
Proceedings of the National Academy of Sciences of the United States of America, 1976 Serum RNase (ribonuclease) of normal persons and of patients with pancreatitis, carcinoma of pancreas, or other neoplasms was determined with poly(C) as substrate. Strikingly abnormal elevations occur in the serum RNase of patients with pancreatic cancer.
K. Reddi, J. Holland
semanticscholar +1 more source
Highly sensitive nuclease assay based on chemically-modified DNA or RNA [PDF]
, 2014 Nucleolytic enzymes are associated with various diseases, and several methods have been developed for their detection. DNase expression is modulated in such diseases as acute myocardial infarction, transient myocardial ischemia, oral cancer, stomach ...
Sato Shinobu, Takenaka Shigeori
core +2 more sources
A comparison of leaf and pancreatic ribonuclease [PDF]
Biochemical Journal, 1955 Holden, M., Pirie, N. W.
openaire +3 more sources
Azotobacter vinelandii RNA polymerase. II - Effect of ribonuclease on polymerase activity [PDF]
Ribonuclease effect on polymerase activity during ribonucleic acid synthesis ...
Krakow, J. S.
core +1 more source
Angewandte Chemie International Edition, EarlyView.Bioreversible Arginine Modification of amine‐containing protein residues (termed BioRAM) allows the serum‐compatible, readily accessible, and efficient delivery of native proteins into live cells. Combined with cell‐penetrating peptide (CPP) additives, BioRAM results in intracellular RNase A activity at nanomolar concentrations, thus enabling the ...
Jonathan Franke +3 more
wiley +1 more source
Endowing Human Pancreatic Ribonuclease with Toxicity for Cancer Cells*
Journal of Biological Chemistry, 2001 Onconase® is an amphibian protein that is now in Phase III clinical trials as a cancer chemotherapeutic. Human pancreatic ribonuclease (RNase 1) is homologous to Onconase® but is not cytotoxic. Here, ERDD RNase 1, which is the L86E/N88R/G89D/R91D variant
P. Leland +3 more
semanticscholar +1 more source