Results 111 to 120 of about 23,635 (226)

Pancreatic ribonucleases

, 1976
Ribonuclease from cow pancreas was the first enzyme of which thr amino acid sequence was determined. ...
openaire   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Realistic protein-protein association rates from a simple diffusional model neglecting long-range interactions, free energy barriers, and landscape ruggedness

, 2004
We develop a simple but rigorous model of protein-protein association kinetics based on diffusional association on free energy landscapes obtained by sampling configurations within and surrounding the native complex binding funnels.
Camacho, David Baker, Debye, Ermak, Gabdoulline, Gabdoulline, Gabdoulline, Gray, Janin, Maximilian Schlosshauer, Northrup, Schlosshauer, Schreiber, Selzer, Shoup, Smoluchowski, Vijayakumar, Zhou   +17 more
core   +2 more sources

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, Volume 16, Issue 2, Page 299-313, February 2026.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Bisphenol B Exposure Induces Miscarriage by Suppressing Migration/Invasion and Migrasome Formation

Advanced Science, Volume 13, Issue 7, 3 February 2026.
BPB (Bisphenol B) exposure up‐regulates ER (estrogen receptor) levels, enhances its interactions with the lnc‐HZ04 promoter region, and thus promotes ER‐mediated lnc‐HZ04 transcription. Subsequently, lnc‐HZ04 suppresses TCF4 (transcription factor 4)‐mediated PKCA (protein kinase C alpha) transcription and subsequently suppresses migration/invasion and ...
Wenxin Huang, Manli Wang, Yi Sun, Xiaoping Yue, Xun Li, Yanbing Lin, Geng Guo, Depeng Zhao, Qigang Fan, Xiaoling Ma, Zhihong Zhang, Shuaishuai Xing, Xiaoting Shen, Huidong Zhang   +13 more
wiley   +1 more source

Cidea Targeting Protects Cochlear Hair Cells and Hearing Function From Drug‐ and Noise‐Induced Damage

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Acquired sensorineural hearing loss is primarily caused by the damage or loss of cochlear hair cells, induced by factors such as noise exposure and ototoxic drugs. The deficiency of apoptosis‐inducing gene Cidea in Cidea KO mice or by delivering CRISPR/SlugCas9‐HF via AAV to edit Cidea effectively alleviated hair cell damage and hearing loss caused by ...
Shasha Zhang, Ruiying Qiang, Yuan Zhang, Jinxian Wan, Chen Tao, Ying Dong, Xujun Tang, Li Xu, Hairong Xiao, Yanqin Lin, Wei Tong, Ying Ma, Yongming Wang, Peng Li, Renjie Chai   +14 more
wiley   +1 more source

Biological Templates for Gold Nanocluster Assembly: Design and Biomedical Applications

Aggregate, Volume 7, Issue 2, February 2026.
The review discusses the fundamental properties of ultrasmall gold nanoclusters and their surface modification strategies for targeted biomedical use. It examines biologically guided assembly processes and their effects on optical behavior, particularly aggregation‐induced emission.
Zeineb Ayed, Abdallah Alhalabi, Didier Gasparutto, Xavier Le Guével   +3 more
wiley   +1 more source

Ameliorative Effects of Aerobic Exercise Combined With Lycium barbarum Polysaccharide‐Mediated Gut Microbiota Remodeling on Glycolipid Abnormalities in Type 2 Diabetic Rats

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
This schematic illustrates the protective effects of aerobic exercise and Lycium barbarum polysaccharide in a rat model of type 2 diabetes mellitus (T2DM), which was induced by high‐fat/high‐sugar feeding and streptozotocin (STZ) injection. Both interventions target the gut microbiota to promote short‐chain fatty acid production, thereby regulating ...
Jing‐feng Wang, Shuo Feng, Xuan Cao, Xiao‐lin Li   +3 more
wiley   +1 more source

Loss of METTL3 m6A methyltransferase results in short‐term progression and poor treatment outcome of bladder cancer patients

International Journal of Cancer, Volume 158, Issue 3, Page 763-774, 1 February 2026.
What's new? Bladder cancer exhibits a highly heterogeneous molecular landscape and treatment response. The dysregulation of RNA modifications such as m6A has been involved in cancer initiation and progression. This study comprehensively analyzed the expression of the main catalytic component of the m6A methylation machinery in bladder tumors across one
Katerina‐Marina Pilala, Stella Koroneou, Maria‐Alexandra Papadimitriou, Konstantina Panoutsopoulou, Konstantinos Soureas, Georgios‐Christos Giagkos, Panagiotis Levis, Dimitrios Linardoutsos, Konstantinos Stravodimos, Margaritis Avgeris, Andreas Scorilas   +10 more
wiley   +1 more source