Results 131 to 140 of about 12,408 (251)

Tumor‐Mimic Artificial Cell Integrated With In Situ Synthetic Biology for Testing of Antitumor Drug Sensitivity

Exploration, Volume 6, Issue 3, June 2026.
A biomimetic artificial cell model platform integrating in situ synthetic biology is developed, which can show antitumor drug response to simulated cells derived from cell membranes of different tumor cells. It has excellent performance in indicating the curative effect of drugs at the cellular level and provides a novel approach for enhancing the ...
Chaoyang Guan, Runchi Zhang, Zhihui Zhou, Pei Sun, Yichun Mao, Changqing Mao, Yonggeng Ma, Guifang Chen, Qiuhong Man, Chang Feng   +9 more
wiley   +1 more source

Combined evaluation of serum ribonuclease and ferritin: any advantages in pancreatic cancer diagnosis?

, 1984
I.F. 1.312 Abstract: In 116 subjects, serum ribonuclease (RNase) and ferritin were determined in order to evaluate whether their combined evaluation might improve the diagnostic accuracy of each test. Significantly higher levels were found in pancreatic
FABRIS C., GRASSI F., PICCOLI, ANTONIO, NITTI, DONATO, DEL FAVERO G., NACCARATO R., FARINI R., BROSOLO P.   +7 more
core  

Anfinsen Redux: Ribonuclease Folding in the Single-Molecule Regime. [PDF]

J Am Chem Soc
Melkonian AV, Wralstad EC, Raines RT, Walt DR.   +3 more
europepmc   +1 more source

Targeted Delivery of mRNA to the Heart via Extracellular Vesicles or Lipid Nanoparticles

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Efficient and specific delivery of mRNA to target tissues is critical for maximising therapeutic benefits while minimising off‐target effects and systemic toxicity. Systemic administration of mRNA using lipid nanoparticles (LNPs) or extracellular vesicles (EVs) typically leads to predominant accumulation in the liver.
Muhammad Nawaz, Benyapa Tangruksa, Sepideh Heydarkhan‐Hagvall, Franziska Kohl, Hernán González‐King Garibotti, Yujia Jing, Zahra Payandeh, Azadeh Reyahi, Karin Jennbacken, John Wiseman, Leif Hultin, Lennart Lindfors, Jane Synnergren, Hadi Valadi   +13 more
wiley   +1 more source

RNase A is inhibited by the cysteine-rich protein thionein but not by the metal-containing form metallothionein. [PDF]

Mol Cell Biochem
Trujillo-González F, Muñoz-Granados IA, Sanchez-Gaytan BL, Brambila E, Perez-Aguilar JM.   +4 more
europepmc   +1 more source

Intrachain Disulfide Bridges of Bovine Seminal Ribonuclease

, 1979
The pairing of the four intrachain disulfide bonds of bovine se minal ribonuclease, a dimeric protein isolated from bovine seminal plasma, has been established by the isolation and characterization of the cystine peptides obtained from a ...
D'ALESSIO, GIUSEPPE, DI DONATO, ALBERTO
core  

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

ω‐3PUFAs Inhibit Gallbladder Cancer Through Enhancing STK31 Methylation

Molecular Nutrition &Food Research, Volume 70, Issue 11, 15 June 2026.
ABSTRACT Gallbladder cancer (GBC) is an aggressive malignancy with limited treatment options. ω‐3PUFAs have known anticancer activity, but their role in GBC remains unclear. The anti‐GBC effects of ω‐3PUFAs (DHA/EPA) were evaluated using in vitro assays and mouse xenograft models.
Shuang‐Xing Li, Wei‐Yu Zhu, Hai‐Ying Peng, Bin Zhang, Zhu‐Ying Lin, Song‐Lin Yang, Yi‐Yi Zhao, Hui Gao, Shan He, Yuan Liu, Xiao‐Dan Wang, Yang‐Fan Guo, Wen‐Ju Wang, Zong‐Liu Hou, Ming‐Yao Meng, Li‐Wei Liao, Lin Li   +16 more
wiley   +1 more source

Pan-Cancer Analysis Reveals Ribonuclease K (RNASEK) as a Potential Prognostic Biomarker in Pancreatic Cancer and a Diagnostic Indicator Across Multiple Human Cancers. [PDF]

Cureus
Hassan Elsheikh NA, A Abaker NA, Almrshoud MF, A Abdalfadil FA, Alfaki M.   +4 more
europepmc   +1 more source

Inhibition of PHF1 promotes ferroptosis via IRES‐dependent Snail translation regulation in pancreatic ductal adenocarcinoma

VIEW, Volume 7, Issue 3, June 2026.
PHF1 is a known epigenetic regulator involved in transcriptional silencing in cancer. In this study, we identified PHF1 as an oncogene that promotes PDAC progression and demonstrated that its inhibition induces ferroptosis. Mechanistically, PHF1 physically interacts with the FBL/NOP56/NOP58 snoRNP complex to enhance the IRES‐dependent translation of ...
Yujiao Xie, Shan Jin, Yao Zhan, Tiantian Du, Yaqi Dong, Peilong Li, Xiaoshi Zhang, Qiuchen Qi, Jie Gao, Chuanxin Wang   +9 more
wiley   +1 more source