Results 21 to 30 of about 433,059 (284)
OncoTarget, 2018 The microRNA-200 (miR-200) family is frequently down-regulated in tumors, including pancreatic adenocarcinomas (PDACs). In this study we have examined the mechanisms involved in the loss of miR-200s in tumoral pancreatic cells.
F. Boudouresque +7 more
semanticscholar +1 more source
A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small RNAs for broad applications. [PDF]
, 2015 RNA research and therapy relies primarily on synthetic RNAs. We employed recombinant RNA technology toward large-scale production of pre-miRNA agents in bacteria, but found the majority of target RNAs were not or negligibly expressed. We thus developed a
Chen, Qiu-Xia +4 more
core +2 more sources
OncoTarget, 2016 Ribonucleases represent a new class of antitumor RNA-damaging drugs. However, many wild-type members of the vertebrate secreted ribonuclease family are not cytotoxic because they are not able to evade the cytosolic ribonuclease inhibitor.
semanticscholar +1 more source
Mitochondrial Translation Products before and after Integration into the Mitochondrial Membrane in Neurospora crassa [PDF]
, 1972 # 1. Nascent translation products on mitochondrial ribosomes were selectively labeled in vivo in the presence of cycloheximide with radioactive leucine. They were isolated together with the ribosomes. # 2.
Michel, Rainer, Neupert, Walter
core +1 more source
Molecules, 2021 Although single targeted anti-cancer drugs are envisaged as safer treatments because they do not affect normal cells, cancer is a very complex disease to be eradicated with a single targeted drug. Alternatively, multi-targeted drugs may be more effective
Glòria García-Galindo +6 more
doaj +1 more source
Scientific Reports, 2014 Pancreatic ribonuclease (RNASE1) is a digestive enzyme that has been one of the key models in studies of evolutionary innovation and functional diversification.
Jiang Liu +7 more
semanticscholar +1 more source
Bovine Pancreatic RNase A: An Insight into the Mechanism of Antitumor Activity In Vitro and In Vivo
Pharmaceutics, 2022 In this investigation, we extensively studied the mechanism of antitumor activity of bovine pancreatic RNase A. Using confocal microscopy, we show that after RNase A penetration into HeLa and B16 cells, a part of the enzyme remains unbound with the ...
Islam Saber Ead Mohamed +6 more
doaj +1 more source
Scientific Reports, 2014 Alterations of carbohydrate structures in cancer cells are the most promising targets for developing clinical diagnostic reagents. Pancreatic cancer is one of the most difficult cancers to diagnose because it lacks definitive symptoms.
D. Nakata
semanticscholar +1 more source
A possible mechanism for cold denaturation of proteins at high pressure [PDF]
, 2003 We study cold denaturation of proteins at high pressures. Using multicanonical Monte Carlo simulations of a model protein in a water bath, we investigate the effect of water density fluctuations on protein stability. We find that above the pressure where
A. Hansen +50 more
core +3 more sources
Molecules, 2020 Oxidative protein folding involves the formation of disulfide bonds and the regeneration of native structure (N) from the fully reduced and unfolded protein (R).
Mahesh Narayan
doaj +1 more source