Results 21 to 30 of about 23,635 (226)

The Selectivity for Tumor Cells of Nuclear-Directed Cytotoxic RNases Is Mediated by the Nuclear/Cytoplasmic Distribution of p27^KIP1

Molecules, 2021
Although single targeted anti-cancer drugs are envisaged as safer treatments because they do not affect normal cells, cancer is a very complex disease to be eradicated with a single targeted drug. Alternatively, multi-targeted drugs may be more effective
Glòria García-Galindo, Jessica Castro, Jesús Matés, Marlon Bravo, Marc Ribó, Maria Vilanova, Antoni Benito   +6 more
doaj   +1 more source

A possible mechanism for cold denaturation of proteins at high pressure [PDF]

, 2003
We study cold denaturation of proteins at high pressures. Using multicanonical Monte Carlo simulations of a model protein in a water bath, we investigate the effect of water density fluctuations on protein stability. We find that above the pressure where
A. Hansen, A. Trovato, B. L. Chen, B. L. Chen, B. Lee, C -J. Tsai, C. N. Pace, C. Vanderzande, D. Chandler, E. Paci, F. H. Stillinger, G. Caldarelli, G. Hummer, G. P. Privalov, G. Panick, G. W. Robinson, H. Ludwing, H. S. Chan, H. S. Frank, J. Jonas, J. Zhang, J. Zipp, K. A. Dill, K. A. Dill, K. A. Dill, K. A. Dill, K. A. T. Silverstein, K. C. Cho, K. F. Lau, L. R. Pratt, L. Smeller, M. W. Mahoney, N. Muller, O. Collet, P. Bruscolini, P. L. Privalov, P. L. Privalov, P. R. ten Wolde, P. R. ten Wolde,, R. A. Pierotti, S. A. Hawley, S. A. Hawley, S. Chan, S. J. Gill, S. Kunugi, S. Shimizu, S. Shimizu, V. A. Payne, V. F. Petrenko, W. Kauzmann, Y. Nozaki   +50 more
core   +3 more sources

Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats [PDF]

, 2013
Background: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expression pattern is unclear ...
Csonka, Csaba, Csont, Tamás Bálint, Fekete, Veronika, Ferdinandy, Péter, Gyémánt, Nóra, Kocsis-Fodor, Gabriella, Pipis, Judit, Puskás, László, Szűcs, Gergő, Sárközy, Márta, Zvara, Ágnes   +10 more
core   +3 more sources

Extraction of high-quality RNA from mouse pancreatic tumors

MethodsX, 2020
Extraction of high-quality RNA from pancreatic tumors for sequencing purposes is technically challenging, as the pancreas is an organ rich in ribonucleases.
Kranthi Kumar Chougoni, Steven R. Grossman   +1 more
doaj   +1 more source

Bovine Pancreatic RNase A: An Insight into the Mechanism of Antitumor Activity In Vitro and In Vivo

Pharmaceutics, 2022
In this investigation, we extensively studied the mechanism of antitumor activity of bovine pancreatic RNase A. Using confocal microscopy, we show that after RNase A penetration into HeLa and B16 cells, a part of the enzyme remains unbound with the ...
Islam Saber Ead Mohamed, Aleksandra V. Sen’kova, Oleg V. Markov, Andrey V. Markov, Innokenty A. Savin, Marina A. Zenkova, Nadezhda L. Mironova   +6 more
doaj   +1 more source

Revisiting the Formation of a Native Disulfide Bond: Consequences for Protein Regeneration and Beyond

Molecules, 2020
Oxidative protein folding involves the formation of disulfide bonds and the regeneration of native structure (N) from the fully reduced and unfolded protein (R).
Mahesh Narayan
doaj   +1 more source

Cellular response to the ribonuclease injection; a morphologic and cytochemical study [PDF]

, 1960
By the repeated injection of RNase into mice the histological, cytochemical and electronmicroscope observations of several tissues and the quantitative estimation of DNA contents per cell in liver have been conducted.
Kimoto, Tetsuo, Matsuoka, Iwao, Seno, Satimaru, Utsumi, Kozo   +3 more
core   +1 more source

Preliminary investigation of deoxyoligonucleotide binding to ribonuclease A using mass spectrometry: An attempt to develop a lab experience for undergraduates [version 2; referees: 2 approved]

F1000Research, 2018
Deoxyoligonucleotide binding to bovine pancreatic ribonuclease A (RNase A) was investigated using electrospray ionization ion-trap mass spectrometry (ESI-IT-MS). Deoxyoligonucleotides included CCCCC (dC5) and CCACC (dC2AC2).
Daniel D. Clark
doaj   +1 more source

Construction of an RNA-Binding Protein-Related Prognostic Model for Pancreatic Adenocarcinoma Based on TCGA and GTEx Databases

Frontiers in Genetics, 2021
Background: Recently, RNA-binding proteins (RBPs) were reported to interact with target mRNA to regulate gene posttranscriptional expression, and RBP-mediated RNA modification can regulate the expression and function of proto-oncogenes and tumor ...
Xin Wen, Zhiying Shao, Zhiying Shao, Shuyi Chen, Wei Wang, Yan Wang, Jinghua Jiang, Qinggong Ma, Longzhen Zhang, Longzhen Zhang, Longzhen Zhang   +10 more
doaj   +1 more source

Mitochondrial Translation Products before and after Integration into the Mitochondrial Membrane in Neurospora crassa [PDF]

, 1972
# 1. Nascent translation products on mitochondrial ribosomes were selectively labeled in vivo in the presence of cycloheximide with radioactive leucine. They were isolated together with the ribosomes. # 2.
Michel, Rainer, Neupert, Walter
core   +1 more source