Results 41 to 50 of about 80,368 (300)

CRYSTALLINE RIBONUCLEASE [PDF]

Journal of General Physiology, 1940
1. A crystalline enzyme capable of digesting yeast nucleic acid has been isolated from fresh beef pancreas. 2. The enzyme called "ribonuclease" is a soluble protein of albumin type. Its molecular weight is about 15,000. Its isoelectric point is in the region of pH 8.0. 3.
openaire   +2 more sources

Evasion of Ribonuclease Inhibitor as a Determinant of Ribonuclease Cytotoxicity [PDF]

Current Pharmaceutical Biotechnology, 2008
Onconase (ONC) is an amphibian member of the bovine pancreatic ribonuclease (RNase A) superfamily that exhibits innate antitumoral activity. ONC has been granted both orphan-drug and fast-track status by the U.S. Food and Drug Administration for the treatment of malignant mesothelioma, and is poised to become the first chemotherapeutic agent based on a
Thomas J, Rutkoski, Ronald T, Raines
openaire   +2 more sources

Ultra-high resolution X-ray structure of orthorhombic bovine pancreatic Ribonuclease A at 100K [PDF]

, 2023
The crystal structure of orthorhombic Bovine Pancreatic Ribonuclease A has been determined to 0.85 Å resolution using low temperature, 100 K, synchrotron X-ray data collected at 16000 keV (λ = 0.77 Å). This is the first ultra-high-resolution structure of
Palmer. R.A., Lisgarten J.N., Konc. J., Lisgarten, D., Naylor. C.E., Howlin. B.J., Najmudin. S., Talbert. R.C., Cooper. J.B., Lobley. C.M.C.   +9 more
core   +1 more source

Structure and evolution of pancreatic ribonuclease [PDF]

, 1979
Dit proefschrift gaat over de structuur en de evolutie van het spijsverteringsenzym ribonuclease. In het eerste hoofdstuk wordt in het kort de stand van zaken beschreven in de eiwitchemie, waarvoor ribonuclease aI drie decennia dienst doet aIs ...
Lenstra, Johannes Arjen
core   +3 more sources

Colletotrichum fructicola co-opts cytotoxic ribonucleases that antagonize host competitive microorganisms to promote infection

mBio
Phytopathogens secrete numerous molecules into the environment to establish a microbial niche and facilitate host infection. The phytopathogenic fungus Colletotrichum fructicola, which causes pear anthracnose, can colonize different plant tissues like ...
Chunhao Wang, Mengqing Han, Yanyan Min, Jiayi Hu, Yuemin Pan, Lili Huang, Jiajun Nie   +6 more
doaj   +1 more source

NaPi/SX-RNase segregates as a functional S-RNase and is induced under phosphate deficiency in Nicotiana alata

Biologia Plantarum, 2018
In plants, class III T2 RNases involves two groups of structurally similar proteins, but with different biological functions: S-RNases and non-S-RNases.
H. J. Rojas, C. Caspani, E. G. Escobar, R. Quiroga, A. Goldraij   +4 more
doaj   +1 more source

Regulation of RNase E during the UV stress response in the cyanobacterium Synechocystis sp. PCC 6803

mLife, 2023
Endoribonucleases govern the maturation and degradation of RNA and are indispensable in the posttranscriptional regulation of gene expression. A key endoribonuclease in Gram‐negative bacteria is RNase E.
Satoru Watanabe, Damir Stazic, Jens Georg, Shota Ohtake, Yutaka Sakamaki, Megumi Numakura, Munehiko Asayama, Taku Chibazakura, Annegret Wilde, Claudia Steglich, Wolfgang R. Hess   +10 more
doaj   +1 more source

RNase R, a New Virulence Determinant of Streptococcus pneumoniae

Microorganisms, 2022
Pneumococcal infections have increasingly high mortality rates despite the availability of vaccines and antibiotics. Therefore, the identification of new virulence determinants and the understanding of the molecular mechanisms behind pathogenesis have ...
Cátia Bárria, Dalila Mil-Homens, Sandra N. Pinto, Arsénio M. Fialho, Cecília M. Arraiano, Susana Domingues   +5 more
doaj   +1 more source

The RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognition

, 2008
The degradation of the poly(A) tail is crucial for posttranscriptional gene regulation and for quality control of mRNA. Poly(A)-specific ribonuclease (PARN) is one of the major mammalian 3’ specific exo-ribonucleases involved in the degradation of the ...
Naohiro Kobayashi, Shirouzu, Mikako, Sakura Suzuki, Nagata, Takashi, Yoshihide Hayashizaki, Takashi Nagata, Yutaka Muto, Takanori Kigawa, Kobayashi, Naohiro, Peter Güntert, Mikako Shirouzu, Muto, Yutaka, Akiko Tanaka, Endo, Ryuta, Makoto Inoue, Hayashizaki, Yoshihide, Terada, Takaho, Inoue, Makoto, Kigawa, Takanori, Suzuki, Sakura, Yokoyama, Shigeyuki, Takaho Terada, Ryuta Endo, Shigeyuki Yokoyama, Güntert, Peter, Tanaka, Akiko   +25 more
core   +1 more source

MCPIP1 ribonuclease can bind and cleave AURKA mRNA in MYCN-amplified neuroblastoma cells

RNA Biology, 2021
The role of the inflammation-silencing ribonuclease, MCPIP1 (monocyte chemoattractant protein-induced protein 1), in neoplasia continuous to emerge. The ribonuclease can cleave not only inflammation-related transcripts but also some microRNAs (miRNAs ...
Iwona Nowak, Elżbieta Boratyn, Sebastian Student, Stephan F. Bernhart, Jörg Fallmann, Małgorzata Durbas, Peter F. Stadler, Hanna Rokita   +7 more
doaj   +1 more source