Results 41 to 50 of about 71,397 (266)
Frontiers in Microbiology, 2022 During the plant infection process, pathogens can secrete several effectors. Some of the effectors are well-known for their roles in regulating plant immunity and promoting successful pathogen colonization.
Shidao He +6 more
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Philosophical Transactions of the Royal Society B: Biological Sciences, 2011 The gene coding for the RNA subunit of ribonuclease P (RNase P) is essential in all free-living organisms. The RNA subunit, itself, is an enzyme and, from its evolutionary tree, we can infer that it is a very ancient molecule. The specificity of this enzyme is that it cleaves other RNA molecules at the junction of single-stranded and the 5′ end of ...
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
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Genetic diversity of human RNase 8
BMC Genomics, 2012 Background Ribonuclease 8 is a member of the RNase A family of secretory ribonucleases; orthologs of this gene have been found only in primate genomes. RNase 8 is a divergent paralog of RNase 7, which is lysine-enriched, highly conserved, has prominent ...
Chan Calvin C +4 more
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Secreted alkaline ribonucleases of micromycetes
Учёные записки Казанского университета: Серия Естественные науки, 2020 Many ribonucleases (RNases) have a selective cytotoxic effect on tumor cells. Of particular interest are enzymes that are phylogenetically distant from mammalian RNases, such as amphibian, fungal, and bacterial RNases, all insensitive to the action of ...
V.V. Ulyanova +5 more
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The binding of IMP to Ribonuclease A [PDF]
The FEBS Journal, 2005 The binding of inosine 5′ phosphate (IMP) to ribonuclease A has been studied by kinetic and X‐ray crystallographic experiments at high (1.5 Å) resolution. IMP is a competitive inhibitor of the enzyme with respect to C>p and binds to the catalytic cleft by anchoring three IMP molecules in a novel binding mode. The three IMP molecules are connected to
Hatzopoulos, G. N. +4 more
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni
eLife, 2019 CRISPR/Cas9-based genome editing has yet to be reported in species of the Platyhelminthes. We tested this approach by targeting omega-1 (ω1) of Schistosoma mansoni as proof of principle.
Wannaporn Ittiprasert +20 more
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Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Novel Aspects of Polynucleotide Phosphorylase Function in Streptomyces
Antibiotics, 2018 Polynucleotide phosphorylase (PNPase) is a 3′–5′-exoribnuclease that is found in most bacteria and in some eukaryotic organelles. The enzyme plays a key role in RNA decay in these systems.
George H. Jones
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