Results 21 to 30 of about 71,397 (266)

Research on structure, mechanism and regulation of enzyme activity. Works of Nobel laureates C. Anfinsen, S. Moore, W. Stein, S. Prusiner, J. Skou, P. Boyer, J. Walker [PDF]

The Ukrainian Biochemical Journal, 2020
Although the protein nature of enzymes was identified in the 40s of the 20th century, (we wrote about this in our previous article), their molecular structure and the specific mechanism of action remained unknown.
R. P. Vynogradova, V. M. Danilova, S. V. Komisarenko   +2 more
doaj   +1 more source

CRYSTALLINE RIBONUCLEASE [PDF]

Journal of General Physiology, 1940
1. A crystalline enzyme capable of digesting yeast nucleic acid has been isolated from fresh beef pancreas. 2. The enzyme called "ribonuclease" is a soluble protein of albumin type. Its molecular weight is about 15,000. Its isoelectric point is in the region of pH 8.0. 3.
openaire   +2 more sources

Colletotrichum fructicola co-opts cytotoxic ribonucleases that antagonize host competitive microorganisms to promote infection

mBio
Phytopathogens secrete numerous molecules into the environment to establish a microbial niche and facilitate host infection. The phytopathogenic fungus Colletotrichum fructicola, which causes pear anthracnose, can colonize different plant tissues like ...
Chunhao Wang, Mengqing Han, Yanyan Min, Jiayi Hu, Yuemin Pan, Lili Huang, Jiajun Nie   +6 more
doaj   +1 more source

Generation of 2′,3′-Cyclic Phosphate-Containing RNAs as a Hidden Layer of the Transcriptome

Frontiers in Genetics, 2018
Cellular RNA molecules contain phosphate or hydroxyl ends. A 2′,3′-cyclic phosphate (cP) is one of the 3′-terminal forms of RNAs mainly generated from RNA cleavage by ribonucleases.
Megumi Shigematsu, Takuya Kawamura, Yohei Kirino   +2 more
doaj   +1 more source

Regulation of RNase E during the UV stress response in the cyanobacterium Synechocystis sp. PCC 6803

mLife, 2023
Endoribonucleases govern the maturation and degradation of RNA and are indispensable in the posttranscriptional regulation of gene expression. A key endoribonuclease in Gram‐negative bacteria is RNase E.
Satoru Watanabe, Damir Stazic, Jens Georg, Shota Ohtake, Yutaka Sakamaki, Megumi Numakura, Munehiko Asayama, Taku Chibazakura, Annegret Wilde, Claudia Steglich, Wolfgang R. Hess   +10 more
doaj   +1 more source

RNase R, a New Virulence Determinant of Streptococcus pneumoniae

Microorganisms, 2022
Pneumococcal infections have increasingly high mortality rates despite the availability of vaccines and antibiotics. Therefore, the identification of new virulence determinants and the understanding of the molecular mechanisms behind pathogenesis have ...
Cátia Bárria, Dalila Mil-Homens, Sandra N. Pinto, Arsénio M. Fialho, Cecília M. Arraiano, Susana Domingues   +5 more
doaj   +1 more source

Evasion of Ribonuclease Inhibitor as a Determinant of Ribonuclease Cytotoxicity [PDF]

Current Pharmaceutical Biotechnology, 2008
Onconase (ONC) is an amphibian member of the bovine pancreatic ribonuclease (RNase A) superfamily that exhibits innate antitumoral activity. ONC has been granted both orphan-drug and fast-track status by the U.S. Food and Drug Administration for the treatment of malignant mesothelioma, and is poised to become the first chemotherapeutic agent based on a
Thomas J, Rutkoski, Ronald T, Raines
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Sialic Acid-Binding Lectin from Bullfrog Eggs Exhibits an Anti-Tumor Effect Against Breast Cancer Cells Including Triple-Negative Phenotype Cells

Molecules, 2018
Sialic acid-binding lectin from Rana catesbeiana eggs (cSBL) is a multifunctional protein that has lectin and ribonuclease activity. In this study, the anti-tumor activities of cSBL were assessed using a panel of breast cancer cell lines. cSBL suppressed
Takeo Tatsuta, Shoko Sato, Toshiyuki Sato, Shigeki Sugawara, Tsuneyoshi Suzuki, Akiyoshi Hara, Masahiro Hosono   +6 more
doaj   +1 more source

MCPIP1 ribonuclease can bind and cleave AURKA mRNA in MYCN-amplified neuroblastoma cells

RNA Biology, 2021
The role of the inflammation-silencing ribonuclease, MCPIP1 (monocyte chemoattractant protein-induced protein 1), in neoplasia continuous to emerge. The ribonuclease can cleave not only inflammation-related transcripts but also some microRNAs (miRNAs ...
Iwona Nowak, Elżbieta Boratyn, Sebastian Student, Stephan F. Bernhart, Jörg Fallmann, Małgorzata Durbas, Peter F. Stadler, Hanna Rokita   +7 more
doaj   +1 more source