Results 21 to 30 of about 90,209 (297)
Rethinking Leucine Zipper : ribonuclease activity and structural dynamics of a ubiquitous oligomerization motif [PDF]
, 2011 This dissertation focuses on structural, dynamic and catalytic properties of a Leucine Zipper (LZ) motif – a family of protein oligomerization domains which belong to the structural class of coiled coil proteins.
Nikolaev, Yaroslav
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Structural investigations of proteins encoded by SARS‐CoV‐2
FEBS Open Bio, 2022 It is hard to overestimate the influence of the COVID‐19 pandemic on scientific research in the last two and a half years. Within a few weeks after the first cases of the disease were reported, the causative agent, now known as SARS‐CoV‐2, was identified,
Alexander Wlodawer
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Molecules, 2018 Sialic acid-binding lectin from Rana catesbeiana eggs (cSBL) is a multifunctional protein that has lectin and ribonuclease activity. In this study, the anti-tumor activities of cSBL were assessed using a panel of breast cancer cell lines. cSBL suppressed
Takeo Tatsuta +6 more
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eLife, 2020 Cyclic nucleotide second messengers are increasingly implicated in prokaryotic anti-viral defence systems. Type III CRISPR systems synthesise cyclic oligoadenylate (cOA) upon detecting foreign RNA, activating ancillary nucleases that can be toxic to ...
Januka S Athukoralage +5 more
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Molecules, 2021 Although single targeted anti-cancer drugs are envisaged as safer treatments because they do not affect normal cells, cancer is a very complex disease to be eradicated with a single targeted drug. Alternatively, multi-targeted drugs may be more effective
Glòria García-Galindo +6 more
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Novel Ribonuclease Activity Differs between Fibrillarins from Arabidopsis thaliana
Frontiers in Plant Science, 2017 Fibrillarin is one of the most important nucleolar proteins that have been shown as essential for life. Fibrillarin localizes primarily at the periphery between fibrillar center and dense fibrillar component as well as in Cajal bodies.
Ulises Rodriguez-Corona +5 more
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Research on structure, mechanism and regulation of enzyme activity. Works of Nobel laureates C. Anfinsen, S. Moore, W. Stein, S. Prusiner, J. Skou, P. Boyer, J. Walker [PDF]
The Ukrainian Biochemical Journal, 2020 Although the protein nature of enzymes was identified in the 40s of the 20th century, (we wrote about this in our previous article), their molecular structure and the specific mechanism of action remained unknown.
R. P. Vynogradova +2 more
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CRYSTALLINE RIBONUCLEASE [PDF]
Journal of General Physiology, 1940 1. A crystalline enzyme capable of digesting yeast nucleic acid has been isolated from fresh beef pancreas. 2. The enzyme called "ribonuclease" is a soluble protein of albumin type. Its molecular weight is about 15,000. Its isoelectric point is in the region of pH 8.0. 3.
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Frontiers in Microbiology, 2017 Recently, controllable, targeted proteolysis has emerged as one of the most promising new strategies to study essential genes and otherwise toxic mutations.
Nan Liu +5 more
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Genetic diversity of human RNase 8
BMC Genomics, 2012 Background Ribonuclease 8 is a member of the RNase A family of secretory ribonucleases; orthologs of this gene have been found only in primate genomes. RNase 8 is a divergent paralog of RNase 7, which is lysine-enriched, highly conserved, has prominent ...
Chan Calvin C +4 more
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