Results 11 to 20 of about 71,397 (266)
Ribonucleases as potential therapeutic agents [PDF]
مجله بیوتکنولوژی کشاورزی, 2021 Objective Due to high cytotoxicity effect, ribonucleases (RNases) are known as pharmacological agents with therapeutic potential. The high potential of these enzymes in the destruction of RNA strand and their other substrates and subsequently, cell ...
Masoume Vakili-Azghandi +3 more
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Frontiers in Microbiology, 2022 Angiogenin 4 bearing ribonuclease activity is an endogenous antimicrobial protein expressed in small and large intestine. However, the crucial amino acid residues responsible for the antibacterial activity of Ang4 and its impact on gut microbiota remain ...
Mst. Farzana Sultana +7 more
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RNase Y Autoregulates Its Synthesis in Bacillus subtilis
Microorganisms, 2023 The instability of messenger RNA is crucial to the control of gene expression. In Bacillus subtilis, RNase Y is the major decay-initiating endoribonuclease.
Anna Korobeinikova +3 more
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Structural investigations of proteins encoded by SARS‐CoV‐2
FEBS Open Bio, 2022 It is hard to overestimate the influence of the COVID‐19 pandemic on scientific research in the last two and a half years. Within a few weeks after the first cases of the disease were reported, the causative agent, now known as SARS‐CoV‐2, was identified,
Alexander Wlodawer
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Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2
Protein & Cell, 2017 Mammalian mitochondrial genome encodes a small set of tRNAs, rRNAs, and mRNAs. The RNA synthesis process has been well characterized. How the RNAs are degraded, however, is poorly understood. It was long assumed that the degradation happens in the matrix
Peipei Liu +6 more
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eLife, 2020 Cyclic nucleotide second messengers are increasingly implicated in prokaryotic anti-viral defence systems. Type III CRISPR systems synthesise cyclic oligoadenylate (cOA) upon detecting foreign RNA, activating ancillary nucleases that can be toxic to ...
Januka S Athukoralage +5 more
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Human and mouse angiogenins: Emerging insights and potential opportunities
Frontiers in Microbiology, 2022 Angiogenin, a well-known angiogenic factor, is crucial to the angiogenesis in gastrointestinal tumors. Human angiogenin has only one gene, whereas the murine angiogenin family has extended to incorporate six genes.
Mst. Farzana Sultana +3 more
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Acta Societatis Botanicorum Poloniae, 2012 Plant growth throughout the world is often limited by unfavourable environmental conditions. This paper reports results of a study on long- and short-term osmotic stress (−0.5 MPa) followed by a recovery on in vitro translational capacity of polysomes ...
Wioletta Brosowska-Arendt +1 more
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Molecules, 2021 Although single targeted anti-cancer drugs are envisaged as safer treatments because they do not affect normal cells, cancer is a very complex disease to be eradicated with a single targeted drug. Alternatively, multi-targeted drugs may be more effective
Glòria García-Galindo +6 more
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Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundCell damage, tissue and vascular injury are associated with the exposure and release of intracellular components such as RNA, which promote inflammatory reactions and thrombosis. Based on the counteracting anti‐inflammatory and cardioprotective
Eike Kleinert +15 more
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