Results 51 to 60 of about 156,401 (384)

RNase R, a New Virulence Determinant of Streptococcus pneumoniae

Microorganisms, 2022
Pneumococcal infections have increasingly high mortality rates despite the availability of vaccines and antibiotics. Therefore, the identification of new virulence determinants and the understanding of the molecular mechanisms behind pathogenesis have ...
Cátia Bárria, Dalila Mil-Homens, Sandra N. Pinto, Arsénio M. Fialho, Cecília M. Arraiano, Susana Domingues   +5 more
doaj   +1 more source

Hot and crispy : CRISPR-Cas systems in the hyperthermophile Sulfolobus solfataricus [PDF]

, 2013
The CRISPR (clustered regularly interspaced short palindromic repeats) and Cas (CRISPR-associated) genes are widely spread in bacteria and archaea, representing an intracellular defence system against invading viruses and plasmids.
White, Malcolm F., Zhang, Jing
core   +2 more sources

Evasion of Ribonuclease Inhibitor as a Determinant of Ribonuclease Cytotoxicity [PDF]

Current Pharmaceutical Biotechnology, 2008
Onconase (ONC) is an amphibian member of the bovine pancreatic ribonuclease (RNase A) superfamily that exhibits innate antitumoral activity. ONC has been granted both orphan-drug and fast-track status by the U.S. Food and Drug Administration for the treatment of malignant mesothelioma, and is poised to become the first chemotherapeutic agent based on a
Thomas J. Rutkoski, Ronald T. Raines
openaire   +2 more sources

A functional RNase P protein subunit of bacterial origin in some eukaryotes [PDF]

, 2011
RNase P catalyzes 5′-maturation of tRNAs. While bacterial RNase P comprises an RNA catalyst and a protein cofactor, the eukaryotic (nuclear) variant contains an RNA and up to ten proteins, all unrelated to the bacterial protein.
Bernal Bayard, Pilar, Gopalan, Venkat, Lai, Lien B., Lai, Stella M., Mohannath, Gireesha, Vioque Peña, Agustín   +5 more
core   +1 more source

The ribonuclease polynucleotide phosphorylase can interact with small regulatory RNAs in both protective and degradative modes.

RNA: A publication of the RNA Society, 2016
In all bacterial species examined thus far, small regulatory RNAs (sRNAs) contribute to intricate patterns of dynamic genetic regulation. Many of the actions of these nucleic acids are mediated by well-characterized chaperones such as the Hfq protein ...
K. Bandyra, Dhriti Sinha, J. Syrjanen, B. Luisi, Nicholas R. De Lay   +4 more
semanticscholar   +1 more source

Regulation of RNase E during the UV stress response in the cyanobacterium Synechocystis sp. PCC 6803

mLife, 2023
Endoribonucleases govern the maturation and degradation of RNA and are indispensable in the posttranscriptional regulation of gene expression. A key endoribonuclease in Gram‐negative bacteria is RNase E.
Satoru Watanabe, Damir Stazic, Jens Georg, Shota Ohtake, Yutaka Sakamaki, Megumi Numakura, Munehiko Asayama, Taku Chibazakura, Annegret Wilde, Claudia Steglich, Wolfgang R. Hess   +10 more
doaj   +1 more source

The Selectivity for Tumor Cells of Nuclear-Directed Cytotoxic RNases Is Mediated by the Nuclear/Cytoplasmic Distribution of p27^KIP1

Molecules, 2021
Although single targeted anti-cancer drugs are envisaged as safer treatments because they do not affect normal cells, cancer is a very complex disease to be eradicated with a single targeted drug. Alternatively, multi-targeted drugs may be more effective
Glòria García-Galindo, Jessica Castro, Jesús Matés, Marlon Bravo, Marc Ribó, Maria Vilanova, Antoni Benito   +6 more
doaj   +1 more source

Inferring stabilizing mutations from protein phylogenies : application to influenza hemagglutinin [PDF]

, 2009
One selection pressure shaping sequence evolution is the requirement that a protein fold with sufficient stability to perform its biological functions.
A Akasako, A Akasako, A Cao, A Martin, A Mitraki, A Rambaut, AA Pakula, AR Dinner, AR Fersht, AR Fersht, AS Yang, AS Yang, AV Gribenko, B Steipe, B Steipe, BM Broome, C Pal, C Park, CB Anfinsen, CB Do, CM Dobson, CT Saunders, D Gilis, D Perl, D Shortle, DA Cowan, DA Drummond, DA Drummond, DD Loeb, DM Taverna, DM Taverna, E Capriotti, E Hoffmann, E van Nimwegen, EPC Rocha, Eugene I. Shakhnovich, F Chiti, F Ronquist, G Parisi, GG Brownlee, H Akashi, H Li, H Schindelin, H Zhao, H Zhou, HW Hellinga, I Keller, IE Sanchez, IMP del Pino, J Felsenstein, J Felsenstein, J Felsenstein, J Felsenstein, J Kyte, JA Wells, JB Garrett, JD Bloom, JD Bloom, JD Bloom, JD Bloom, Jesse D. Bloom, JL Thorne, JM Koshi, JP Huelsenbeck, JP Huelsenbeck, JR Cochran, JR Lepock, JV Chamary, K Ishikawa, K Ishikawa, K Katayanagi, KA Bava, KA Gray, KB Zeldovich, KJ Szretter, KL Maxwell, L Giver, L Serrano, M Dai, M Haruki, M Jacob, M Lehmann, M Matrosovich, M Ueda, M Wunderlich, Matthew J. Glassman, MD Kumar, MF Sippl, MM Garcia-Mira, MM Gromiha, MP Canadillas, MS Fornasari, MW Pantoliano, N Amin, N Goldman, N Goldman, N Lartillot, N Tong, R Godoy-Ruiz, R Godoy-Ruiz, R Godoy-Ruiz, R Guerois, R Rabadan, R Sakaue, RC Edgar, RJ Ellis, S Govindarajan, S Kimura, S Kimura, S Nakajima, S Sato, SC Choi, SH White, SJ Gamblin, SS Jaswal, U Bastolla, V Parthiban, VG Dugan, VN Uversky, W Besenmatter, WS Sandberg, WSW Wong, XJ Zhang, Y Bao, YY Tseng, Z Chen   +125 more
core   +3 more sources

A Review of Ribonuclease 7’s Structure, Regulation, and Contributions to Host Defense

International Journal of Molecular Sciences, 2016
The Ribonuclease A Superfamily is composed of a group of structurally similar peptides that are secreted by immune cells and epithelial tissues. Several members of the Ribonuclease A Superfamily demonstrate antimicrobial activity, and it has been ...
B. Becknell, J. Spencer
semanticscholar   +1 more source

ConSole: using modularity of contact maps to locate solenoid domains in protein structures. [PDF]

, 2014
BackgroundPeriodic proteins, characterized by the presence of multiple repeats of short motifs, form an interesting and seldom-studied group. Due to often extreme divergence in sequence, detection and analysis of such motifs is performed more reliably on
Godzik, Adam, Hrabe, Thomas
core   +4 more sources