Results 161 to 170 of about 11,347,920 (284)

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

Advanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu   +9 more
wiley   +1 more source

Deuterium spin relaxation of fractionally deuterated ribonuclease H using paired 475 and 950 MHz NMR spectrometers. [PDF]

J Biomol NMR
Bhattacharya S, Varney KM, Dahmane T, Johnson BA, Weber DJ, Palmer AG.   +5 more
europepmc   +1 more source

Inhibition of HBV replication by N-hydroxyisoquinolinedione and N-hydroxypyridinedione ribonuclease H inhibitors. [PDF]

Antiviral Res, 2019
Edwards TC, Mani N, Dorsey B, Kakarla R, Rijnbrand R, Sofia MJ, Tavis JE.   +6 more
europepmc   +1 more source

A sensitive fluorometric bio-barcodes immunoassay for detection of triazophos residue in agricultural products and water samples by iterative cycles of DNA-RNA hybridization and dissociation of fluorophores by Ribonuclease H. [PDF]

Sci Total Environ, 2020
Zhang X, Du P, Cui X, Chen G, Wang Y, Zhang Y, Abd El-Aty AM, Hacımüftüoğlu A, Wang J, He H, Jin M, Hammock B.   +11 more
europepmc   +1 more source

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

Selection pressures on evolution of ribonuclease H explored with rigorous free-energy-based design. [PDF]

Proc Natl Acad Sci U S A
Hayes RL, Nixon CF, Marqusee S, Brooks CL.   +3 more
europepmc   +1 more source

Chemical Approaches to Inhibiting the Hepatitis B Virus Ribonuclease H. [PDF]

ACS Infect Dis, 2019
Tavis JE, Zoidis G, Meyers MJ, Murelli RP.   +3 more
europepmc   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Protein-DNA interactions in the 5'-flanking region of the bovine pancreatic ribonuclease gene.

, 1992
COSTANZO C., CARSANA, ANTONELLA, LIEVENS P., PALMIERI M. RIBONUCLEASE G.E.N.E., FURIA A, MEROLA, MARCELLO, MAFFEI L.   +6 more
core   +1 more source