Results 231 to 240 of about 11,347,920 (284)

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

open access: yesAdvanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang   +18 more
wiley   +1 more source

The compactness of ribonuclease A and reduced ribonuclease A [PDF]

open access: yesFEBS Letters, 1998
The compactness of ribonuclease A with intact disulfide bonds and reduced ribonuclease A was investigated by synchrotron small-angle X-ray scattering. The Rg values and the Kratky plots showed that non-reduced ribonuclease A maintain a compact shape with
Yoshiyuki Amemiya   +2 more
exaly   +2 more sources

Calf thymus ribonuclease H IIa activity lacks ribonuclease H specificity

Experientia, 1990
Less purified fractions of ribonuclease H IIa activity of calf thymus display divalent cation-dependent ribonuclease H activity and divalent cation-independent ribonuclease activity. Because the ratio of the two enzyme activities does not change during successive chromatographic procedures, we suggest that ribonuclease H IIa activity is indeed able to ...
H, Vonwirth, P, Frank, W, Büsen
openaire   +2 more sources

Mechanism of Ribonuclease Inhibition by Ribonuclease Inhibitor Protein Based on the Crystal Structure of its Complex with Ribonuclease A

open access: yesJournal of Molecular Biology, 1996
We describe the mechanism of ribonuclease inhibition by ribonuclease inhibitor, a protein built of leucine-rich repeats, based on the crystal structure of the complex between the inhibitor and ribonuclease A.
Boštjan Kobe, Johann Deisenhofer
exaly   +2 more sources

Ribonuclease H

1995
Abstract The ribonuclease H (RNase H) is an essential activity associated with HIV reverse transcriptase (RT). RNase H cleaves the RNA in hybrid RNA-DNA intermediates during minus-strand DNA synthesis initiated from the tRNALys, 3 primer.
Z Hostomska, Z Hostomsky
openaire   +1 more source

Complex between Bovine Ribonuclease A and Porcine Ribonuclease Inhibitor Crystallizes in a Similar Unit Cell as Free Ribonuclease Inhibitor

open access: yesJournal of Molecular Biology, 1994
We obtained three different morphologies of crystals of bovine ribonuclease A and porcine ribonuclease inhibitor. X-ray quality crystals were grown in 1·3 M ammonium sulfate, 100 mM sodium acetate (pH 5·0) and 20 mM dithiothreitol at 21°C. These crystals
Boštjan Kobe, Johann Deisenhofer
exaly   +2 more sources

Distinct Ribonuclease H Activities in Calf Thymus

European Journal of Biochemistry, 1975
Three enzymes with ribonuclease H activity are present in calf thymus. They have been separated on the basis of chromatographic behaviour and molecular weight. They are further distinguished from one another by their ionic requirements and sensitivity to the −SH reagent N‐ethylmaleimide.
W, Büsen, P, Hausen
openaire   +2 more sources

Functions and Structures of Ribonuclease H Enzymes

1995
Ribonuclease H* (RNase H, EC 3.1.26.4) is an endonuclease that specifically hydrolyzes an RNA hybridized to a complementary DNA to produce an oli-goribonucleotide with 5′-phosphate and 3′-hydroxyl groups (Fig. 1). It requires divalent cations, such as Mg2+ and Mn2+, for activity.
S, Kanaya, M, Ikehara
openaire   +2 more sources

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