Results 21 to 30 of about 49,990 (134)

Hot and crispy : CRISPR-Cas systems in the hyperthermophile Sulfolobus solfataricus [PDF]

, 2013
The CRISPR (clustered regularly interspaced short palindromic repeats) and Cas (CRISPR-associated) genes are widely spread in bacteria and archaea, representing an intracellular defence system against invading viruses and plasmids.
White, Malcolm F., Zhang, Jing
core   +2 more sources

Molecular dynamics of C-peptide of ribonuclease A studied by replica-exchange Monte Carlo method and diffusion theory

, 2003
Generalized-ensemble algorithm and diffusion theory have been combined in order to compute the dynamical properties monitored by nuclear magnetic resonance experiments from efficient and reliable evaluation of statistical averages. Replica-exchange Monte
Ayori Mitsutake, Brüschweiler, Cavanagh, Fausti, Giovanni La Penna, Gō, Hansmann, Hukushima, Koradi, Kostov, La Penna, La Penna, Lipari, Masato Masuya, Mitsutake, Mitsutake, Okamoto, Okamoto, Okamoto, Okamoto, Ooi, Osterhout, Pastor, Perico, Rose, Schaefer, Shoemaker, Sippl, Soman, Sugita, Sugita, Tilton, Yuko Okamoto   +32 more
core   +1 more source

Intrinsic Mean Square Displacements in Proteins

, 2012
The thermal mean square displacement (MSD) of hydrogen in proteins and its associated hydration water is measured by neutron scattering experiments and used an indicator of protein function.
A. A. Maradudin, Derya Vural, Henry R. Glyde   +2 more
core   +1 more source

Genomic function during the lampbrush chromosome stage of amphibian oogenesis [PDF]

, 1966
Throughout its lengthy developmental history the disposition of the genetic material in the amphibian oocyte nucleus differs from that in other cell types.
Crippa, Marco, Davidson, Eric H., Kramer, Fred R., Mirsky, Alfred E.   +3 more
core   +1 more source

Convergent Evolution of Ribonuclease H in LTR Retrotransposons and Retroviruses [PDF]

Molecular Biology and Evolution, 2015
Ty3/Gypsy long terminals repeat (LTR) retrotransposons are structurally and phylogenetically close to retroviruses. Two notable structural differences between these groups of genetic elements are 1) the presence in retroviruses of an additional envelope gene, env, which mediates infection, and 2) a specific dual ribonuclease H (RNH) domain encoded by ...
Kirill Ustyantsev, Alexander Blinov, Georgy Smyshlyaev, Olga Novikova   +3 more
openaire   +3 more sources

Crystal structure of xenotropic murine leukaemia virus-related virus (XMRV) ribonuclease H [PDF]

, 2014
RNase H (retroviral ribonuclease H) cleaves the phosphate backbone of the RNA template within an RNA/DNA hybrid to complete the synthesis of double-stranded viral DNA.
Chung, Bong Hyun, Chung, Sang J., Erikson, Raymond Leo, Jung, Suk-Kyeong, Kang, Sunghyun, Kim, Bo Yeon, Kim, Ju Hee, Kim, Seung Jun, Yu, Keum Ran   +8 more
core   +1 more source

A functional RNase P protein subunit of bacterial origin in some eukaryotes [PDF]

, 2011
RNase P catalyzes 5′-maturation of tRNAs. While bacterial RNase P comprises an RNA catalyst and a protein cofactor, the eukaryotic (nuclear) variant contains an RNA and up to ten proteins, all unrelated to the bacterial protein.
Bernal Bayard, Pilar, Gopalan, Venkat, Lai, Lien B., Lai, Stella M., Mohannath, Gireesha, Vioque Peña, Agustín   +5 more
core   +1 more source

Inferring stabilizing mutations from protein phylogenies : application to influenza hemagglutinin [PDF]

, 2009
One selection pressure shaping sequence evolution is the requirement that a protein fold with sufficient stability to perform its biological functions.
A Akasako, A Akasako, A Cao, A Martin, A Mitraki, A Rambaut, AA Pakula, AR Dinner, AR Fersht, AR Fersht, AS Yang, AS Yang, AV Gribenko, B Steipe, B Steipe, BM Broome, C Pal, C Park, CB Anfinsen, CB Do, CM Dobson, CT Saunders, D Gilis, D Perl, D Shortle, DA Cowan, DA Drummond, DA Drummond, DD Loeb, DM Taverna, DM Taverna, E Capriotti, E Hoffmann, E van Nimwegen, EPC Rocha, Eugene I. Shakhnovich, F Chiti, F Ronquist, G Parisi, GG Brownlee, H Akashi, H Li, H Schindelin, H Zhao, H Zhou, HW Hellinga, I Keller, IE Sanchez, IMP del Pino, J Felsenstein, J Felsenstein, J Felsenstein, J Felsenstein, J Kyte, JA Wells, JB Garrett, JD Bloom, JD Bloom, JD Bloom, JD Bloom, Jesse D. Bloom, JL Thorne, JM Koshi, JP Huelsenbeck, JP Huelsenbeck, JR Cochran, JR Lepock, JV Chamary, K Ishikawa, K Ishikawa, K Katayanagi, KA Bava, KA Gray, KB Zeldovich, KJ Szretter, KL Maxwell, L Giver, L Serrano, M Dai, M Haruki, M Jacob, M Lehmann, M Matrosovich, M Ueda, M Wunderlich, Matthew J. Glassman, MD Kumar, MF Sippl, MM Garcia-Mira, MM Gromiha, MP Canadillas, MS Fornasari, MW Pantoliano, N Amin, N Goldman, N Goldman, N Lartillot, N Tong, R Godoy-Ruiz, R Godoy-Ruiz, R Godoy-Ruiz, R Guerois, R Rabadan, R Sakaue, RC Edgar, RJ Ellis, S Govindarajan, S Kimura, S Kimura, S Nakajima, S Sato, SC Choi, SH White, SJ Gamblin, SS Jaswal, U Bastolla, V Parthiban, VG Dugan, VN Uversky, W Besenmatter, WS Sandberg, WSW Wong, XJ Zhang, Y Bao, YY Tseng, Z Chen   +125 more
core   +3 more sources

Ribonuclease H(70) is a component of the yeast nuclear scaffold [PDF]

Journal of Cell Science, 1990
ABSTRACT We have used monospecific antibodies against three ribonuclease H enzymes of Saecharomyces cerevisiae to investigate their intracellular localization. Fractionation experiments, as well as immunocytochemical staining, revealed a predominantly cytoplasmic localization of the RNase H proteins of 42 000 and 70 000, Mr, whereas that
Ulrike Wintersberger, Susan M. Gasser, Thierry Laroche, Robert Karwan, Maximilian Binder   +4 more
openaire   +3 more sources

Synthesis and evaluation of troponoids as a new class of antibiotics [PDF]

, 2018
Novel antibiotics are urgently needed. The troponoids [tropones, tropolones, and α-hydroxytropolones (α-HT)] can have anti-bacterial activity. We synthesized or purchased 92 troponoids and evaluated their antibacterial activities against Staphylococcus ...
Adegboyega, Patrick, Cao, Feng, Donlin, Maureen J., Elagawany, Mohamed, Elgendy, Bahaa, Meyers, Marvin J., Murelli, Ryan P., Orth, Cari, Tavis, John E.   +8 more
core   +4 more sources