Results 141 to 150 of about 19,244,439 (340)
Advanced Functional Materials, EarlyView.The pH‐sensitive His6‐SWNTs, which is functionalized with oligohistidine, can deliver STTM396 molecules into callus cells. The STTM396–SWNT complex treatments enhance shoot regeneration efficiency by regulating the miR396‐GRF module in Arabidopsis and tomato calli.
Yeong Yeop Jeong +7 more
wiley +1 more source
The active site and mechanism of action of bovine pancreatic ribonuclease. 6. Kinetic and spectrophotometric investigation of the interaction of the enzyme with inhibitors and p-nitrophenyl acetate [PDF]
, 1962 CA Ross, AP Mathias, B. R. Rabin
openalex +1 more source
Advanced Healthcare Materials, EarlyView.Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche +16 more
wiley +1 more source
Loss of Individual Mitochondrial Ribonuclease P Complex Proteins Differentially Affects Mitochondrial tRNA Processing In Vivo. [PDF]
Int J Mol Sci, 2021 Saoji M, Sen A, Cox RT.
europepmc +1 more source
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Advanced Healthcare Materials, EarlyView.The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq +4 more
wiley +1 more source
Bio-Protocol, 2015 The ribonuclease H (RNase H) polymerase-independent cleavage assay allows detection and quantification of RNase H activity of reverse transcriptase (RT) enzymes with a hybrid substrate formed by a fluorescein labeled RNA annealed with Dabcyl DNA (Figure ...
Angela Corona, Enzo Tramontano
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This study develops a 3D vascular injury model using a microphysiological system that mimics key features of intimal hyperplasia. Antiproliferative drugs reduced VSMC proliferation but worsened endothelialdenudation. A combination of diphenyleneiodonium and quercetin effectively reduced proliferation and migration of VSMC and inflammation while ...
Ungsig Nam +7 more
wiley +1 more source
, 2003 Generalized-ensemble algorithm and diffusion theory have been combined in order to compute the dynamical properties monitored by nuclear magnetic resonance experiments from efficient and reliable evaluation of statistical averages. Replica-exchange Monte
Ayori Mitsutake +32 more
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Advanced Healthcare Materials, EarlyView.In a murine model of acute lung injury, pulmonary administration of lipid nanoparticles carrying TNFα siRNA enables targeted delivery to immune cells. The study emphasises the importance of optimizing LNP distribution and delivery timing to improve therapeutic outcomes and develop emergency therapies for lung hyperinflammation.
Qinglin Wang +14 more
wiley +1 more source
Circ_RPPH1 facilitates progression of breast cancer via miR-1296-5p/TRIM14 axis
Cancer Biology & TherapyCircular RNA Ribonuclease P RNA Component H1 (circ_RPPH1) and microRNA (miRNA) miR-1296-5p play a crucial role in breast cancer (BC), but the molecular mechanism is vague.
Jing Jiang +6 more
doaj +1 more source