Results 251 to 260 of about 19,244,439 (340)
Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer
Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska+18 more
wiley +1 more source
In vitro hyperprocessing of tRNAs by Bacillus subtilis ribonuclease P RNA [PDF]
Yoshiki Hori, Tatsuki Tanaka, Yo Kikuchi
openalex +1 more source
Inhibition of RNase to Attenuate Fungal‐Manipulated Rhizosphere Microbiome and Diseases
Fusarium graminearum uses its virulence effector Fg12, a fungal RNase, to manipulate the host rhizosphere microbiome and promote infection. Guanosine monophosphate (GMP) blocks Fg12's RNase activity. This reveals a key pathogen‐microbiota interaction mechanism and proposes GMP as a targeted strategy to disarm this core fungal effector, offering a ...
Bo Yang+13 more
wiley +1 more source
Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan+19 more
wiley +1 more source
Specific phosphorothioate substitutions probe the active site of Bacillus subtilis ribonuclease P [PDF]
Sharon M. Crary+2 more
openalex +1 more source
Bacillus secretes nucleases to degrade dsRNA, thereby reducing host's susceptibility to RNAi. [PDF]
Han X, Li H, Xu S, Miao X, Guan R.
europepmc +1 more source
Mapping the active site of ribonuclease P RNA using a substrate containing a photoaffinity agent.
A. Burgin, Norman R. Pace
semanticscholar +1 more source
A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria+5 more
wiley +1 more source
Biosynthesis rates of 13 FFAs are quantitatively calculated in 15 tissues from glucose and an analytical framework to quantitatively calculate inter‐tissue communications of fatty acids between the liver and other tissues is developed. Moreover, the approach is extended to aging condition and a system‐wide decline of fatty acid synthesis in peripheral ...
Beizi Xing+4 more
wiley +1 more source