Results 31 to 40 of about 22,100 (253)
“Life is short, and art is long”: RNA degradation in cyanobacteria and model bacteria
mLife, 2022 RNA turnover plays critical roles in the regulation of gene expression and allows cells to respond rapidly to environmental changes. In bacteria, the mechanisms of RNA turnover have been extensively studied in the models Escherichia coli and Bacillus ...
Ju‐Yuan Zhang +2 more
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Microbial Biotechnology, 2021 Summary The development of synthetic biology has brought an unprecedented increase in the number molecular tools applicable into a microbial chassis.
Patrícia Apura +3 more
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Specific Heat upon Aqueous Unfolding of the Protein Interior: A Theoretical Approach [PDF]
, 2001 We study theoretically the thermodynamics, over a broad temperature range (5 C to 125 C), related to hydrated water upon protein unfolding. The hydration effect is modeled as interacting dipoles in an external field, mimicking the influence from the unfolded surfaces on the surrounding water compared to bulk water.
arxiv +1 more source
Biological Activities of Secretory RNases: Focus on Their Oligomerization to Design Antitumor Drugs
Frontiers in Immunology, 2019 Ribonucleases (RNases) are a large number of enzymes gathered into different bacterial or eukaryotic superfamilies. Bovine pancreatic RNase A, bovine seminal BS-RNase, human pancreatic RNase 1, angiogenin (RNase 5), and amphibian onconase belong to the ...
Giovanni Gotte, Marta Menegazzi
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Molecular dynamics of C-peptide of ribonuclease A studied by replica-exchange Monte Carlo method and diffusion theory [PDF]
, 2003 Generalized-ensemble algorithm and diffusion theory have been combined in order to compute the dynamical properties monitored by nuclear magnetic resonance experiments from efficient and reliable evaluation of statistical averages. Replica-exchange Monte Carlo simulations have been performed with a C-peptide analogue of ribonuclease A, and Smoluchowski
arxiv +1 more source
Ribonuclease-Responsive DNA Nanoswitches
Cell Reports Physical Science, 2020 Summary: DNA has been used in the construction of dynamic DNA devices that can reconfigure in the presence of external stimuli. These nanodevices have found uses in fields ranging from biomedical to materials science applications.
Arun Richard Chandrasekaran +2 more
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Immune Modulation by Human Secreted RNases at the Extracellular Space
Frontiers in Immunology, 2018 The ribonuclease A superfamily is a vertebrate-specific family of proteins that encompasses eight functional members in humans. The proteins are secreted by diverse innate immune cells, from blood cells to epithelial cells and their levels in our body ...
Lu Lu +3 more
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Pharmaceutics, 2020 Current treatments against bacterial infections have severe limitations, mainly due to the emergence of resistance to conventional antibiotics. In the specific case of Pseudomonas aeruginosa strains, they have shown a number of resistance mechanisms to ...
Nathaly Rangel-Muñoz +8 more
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A possible mechanism for cold denaturation of proteins at high pressure [PDF]
, 2002 We study cold denaturation of proteins at high pressures. Using multicanonical Monte Carlo simulations of a model protein in a water bath, we investigate the effect of water density fluctuations on protein stability. We find that above the pressure where water freezes to the dense ice phase ($\approx2$ kbar), the mechanism for cold denaturation with ...
arxiv +1 more source
Strengths and Challenges of Secretory Ribonucleases as AntiTumor Agents
Pharmaceutics, 2021 Approaches to develop effective drugs to kill cancer cells are mainly focused either on the improvement of the currently used chemotherapeutics or on the development of targeted therapies aimed at the selective destruction of cancer cells by steering ...
Jessica Castro +3 more
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