Results 41 to 50 of about 14,217 (304)
Клиническая онкогематология, 2016 The article dwells on ribonucleases (RNAses) whose cytotoxic activity depends on the enzymatic activity, i.e. the ability to catalyze the cleavage of phosphodiester bonds of RNA.
Vadim Sergeevich Pokrovskii +3 more
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The evolutionary history of plant T2/S-type ribonucleases [PDF]
PeerJ, 2017 A growing number of T2/S-RNases are being discovered in plant genomes. Members of this protein family have a variety of known functions, but the vast majority are still uncharacterized.
Karolis Ramanauskas, Boris Igić
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Philosophical Transactions of the Royal Society B: Biological Sciences, 2011 The gene coding for the RNA subunit of ribonuclease P (RNase P) is essential in all free-living organisms. The RNA subunit, itself, is an enzyme and, from its evolutionary tree, we can infer that it is a very ancient molecule. The specificity of this enzyme is that it cleaves other RNA molecules at the junction of single-stranded and the 5′ end of ...
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
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Secreted alkaline ribonucleases of micromycetes
Учёные записки Казанского университета: Серия Естественные науки, 2020 Many ribonucleases (RNases) have a selective cytotoxic effect on tumor cells. Of particular interest are enzymes that are phylogenetically distant from mammalian RNases, such as amphibian, fungal, and bacterial RNases, all insensitive to the action of ...
V.V. Ulyanova +5 more
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Senescent cells limit p53 activity via multiple mechanisms to remain viable
Nature Communications, 2022 To develop therapeutics that selectively eliminate pathological senescent cells it is important to understand their survival mechanisms. Here, the authors show that senescent cells manage to survive by keeping p53 activity in check through multiple ...
Ines Sturmlechner +7 more
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A hydrophobic segment of some cytotoxic ribonucleases [PDF]
, 2013 The exact mechanism by which cytotoxic ribonucleases reach the cytosol of tumor cells remains unclear. The interaction of ribonucleases with a lipid bilayer is involved in the translocation of ribonucleases across the endosomal membrane.
Cherepnev G. +3 more
core
The binding of IMP to Ribonuclease A [PDF]
The FEBS Journal, 2005 The binding of inosine 5′ phosphate (IMP) to ribonuclease A has been studied by kinetic and X‐ray crystallographic experiments at high (1.5 Å) resolution. IMP is a competitive inhibitor of the enzyme with respect to C>p and binds to the catalytic cleft by anchoring three IMP molecules in a novel binding mode. The three IMP molecules are connected to
Hatzopoulos, G. N. +4 more
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
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sRNA-mediated activation of gene expression by inhibition of 5'-3’ exonucleolytic mRNA degradation
eLife, 2017 Post-transcriptional control by small regulatory RNA (sRNA) is critical for rapid adaptive processes. sRNAs can directly modulate mRNA degradation in Proteobacteria without interfering with translation.
Sylvain Durand +4 more
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