Results 31 to 40 of about 15,174 (248)
Microbial Biotechnology, 2021 Summary The development of synthetic biology has brought an unprecedented increase in the number molecular tools applicable into a microbial chassis.
Patrícia Apura +3 more
doaj +1 more source
Transgenic plants as genetic models for studying functions of plant genes
Вавиловский журнал генетики и селекции, 2016 Transgenic plants are widely used for the investigation of functions of particular genes as well as for reconstruction of complex gene networks controlling plant morphology, biochemistry, and physiology during different development stages and in response
A. V. Kochetov, V. K. Shumny
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
The evolutionary history of plant T2/S-type ribonucleases [PDF]
PeerJ, 2017 A growing number of T2/S-RNases are being discovered in plant genomes. Members of this protein family have a variety of known functions, but the vast majority are still uncharacterized.
Karolis Ramanauskas, Boris Igić
doaj +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Decay-Initiating Endoribonucleolytic Cleavage by RNase Y Is Kept under Tight Control via Sequence Preference and Sub-cellular Localisation. [PDF]
PLoS Genetics, 2015 Bacteria depend on efficient RNA turnover, both during homeostasis and when rapidly altering gene expression in response to changes. Nevertheless, remarkably few details are known about the rate-limiting steps in targeting and decay of RNA.
Vanessa Khemici +3 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular evolution of pancreatic-type ribonucleases.
, 1986 Amino acid sequences of 39 mammalian ribonucleases have been used to construct trees by the maximum parsimony procedure. These trees are in fairly good agreement with the biological classification of the species involved.
Beintema, J. J. +8 more
core +1 more source
Overview of Saccharomyces cerevisiae Ribonucleases [PDF]
, 2012 Ribonucleases (RNases) are hydrolytic enzymes that hydrolyze single-stranded RNA, double-stranded RNA, and RNA hybridized with DNA. Cells produce some specific ribonucleases that are needed in a variety of cellular processes, but also a set of general ...
Renata Teparić +5 more
core +1 more source
Ribonucleases and Their Regulatory Role in Gene Expression [PDF]
, 2020 Ribonucleases are essential for the proper biogenesis and turnover of RNAs, and therefore have a major impact on the proper control and fidelity of gene expression. The budding yeast Saccharomyces cerevisiae contain various ribonucleases, each with their
Wang, Charles
core +1 more source