Results 31 to 40 of about 12,443 (264)
Evasion of Ribonuclease Inhibitor as a Determinant of Ribonuclease Cytotoxicity [PDF]
Current Pharmaceutical Biotechnology, 2008 Onconase (ONC) is an amphibian member of the bovine pancreatic ribonuclease (RNase A) superfamily that exhibits innate antitumoral activity. ONC has been granted both orphan-drug and fast-track status by the U.S. Food and Drug Administration for the treatment of malignant mesothelioma, and is poised to become the first chemotherapeutic agent based on a
Thomas J, Rutkoski, Ronald T, Raines
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Transgenic plants as genetic models for studying functions of plant genes
Вавиловский журнал генетики и селекции, 2016 Transgenic plants are widely used for the investigation of functions of particular genes as well as for reconstruction of complex gene networks controlling plant morphology, biochemistry, and physiology during different development stages and in response
A. V. Kochetov, V. K. Shumny
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
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The evolutionary history of plant T2/S-type ribonucleases [PDF]
PeerJ, 2017 A growing number of T2/S-RNases are being discovered in plant genomes. Members of this protein family have a variety of known functions, but the vast majority are still uncharacterized.
Karolis Ramanauskas, Boris Igić
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
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Decay-Initiating Endoribonucleolytic Cleavage by RNase Y Is Kept under Tight Control via Sequence Preference and Sub-cellular Localisation. [PDF]
PLoS Genetics, 2015 Bacteria depend on efficient RNA turnover, both during homeostasis and when rapidly altering gene expression in response to changes. Nevertheless, remarkably few details are known about the rate-limiting steps in targeting and decay of RNA.
Vanessa Khemici +3 more
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The Synthesis of Ribonuclease A
Journal of Biological Chemistry, 1971 A protected linear polypeptide of 124 amino acid residues with the sequence of bovine pancreatic ribonuclease A was synthesized by the solid phase method. The polypeptide was removed from the solid support and purified, and the four disulfide bonds were closed by air oxidation of the reduced form. The synthetic enzyme was fractionated by gel filtration
B, Gutte, R B, Merrifield
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
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Hirsutellin A: A Paradigmatic Example of the Insecticidal Function of Fungal Ribotoxins
Insects, 2013 The fungal pathogen Hirsutella thompsonii produces an insecticidal protein named hirsutellin A (HtA), which has been described to be toxic to several species of mites, insect larvae, and cells.
Álvaro Martínez del Pozo +6 more
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Secreted alkaline ribonucleases of micromycetes
Учёные записки Казанского университета: Серия Естественные науки, 2020 Many ribonucleases (RNases) have a selective cytotoxic effect on tumor cells. Of particular interest are enzymes that are phylogenetically distant from mammalian RNases, such as amphibian, fungal, and bacterial RNases, all insensitive to the action of ...
V.V. Ulyanova +5 more
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