Results 21 to 30 of about 12,443 (264)
Biological Activities of Secretory RNases: Focus on Their Oligomerization to Design Antitumor Drugs
Frontiers in Immunology, 2019 Ribonucleases (RNases) are a large number of enzymes gathered into different bacterial or eukaryotic superfamilies. Bovine pancreatic RNase A, bovine seminal BS-RNase, human pancreatic RNase 1, angiogenin (RNase 5), and amphibian onconase belong to the ...
Giovanni Gotte, Marta Menegazzi
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Pharmaceutics, 2020 Current treatments against bacterial infections have severe limitations, mainly due to the emergence of resistance to conventional antibiotics. In the specific case of Pseudomonas aeruginosa strains, they have shown a number of resistance mechanisms to ...
Nathaly Rangel-Muñoz +8 more
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Immune Modulation by Human Secreted RNases at the Extracellular Space
Frontiers in Immunology, 2018 The ribonuclease A superfamily is a vertebrate-specific family of proteins that encompasses eight functional members in humans. The proteins are secreted by diverse innate immune cells, from blood cells to epithelial cells and their levels in our body ...
Lu Lu +3 more
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Streptomyces RNases – Function and impact on antibiotic synthesis
Frontiers in Microbiology, 2023 Streptomyces are soil dwelling bacteria that are notable for their ability to sporulate and to produce antibiotics and other secondary metabolites. Antibiotic biosynthesis is controlled by a variety of complex regulatory networks, involving activators ...
George H. Jones
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Dual RNase and β-lactamase Activity of a Single Enzyme Encoded in Archaea
Life, 2020 β-lactam antibiotics have a well-known activity which disturbs the bacterial cell wall biosynthesis and may be cleaved by β-lactamases. However, these drugs are not active on archaea microorganisms, which are naturally resistant because of the lack of β ...
Seydina M. Diene +10 more
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CRYSTALLINE RIBONUCLEASE [PDF]
Journal of General Physiology, 1940 1. A crystalline enzyme capable of digesting yeast nucleic acid has been isolated from fresh beef pancreas. 2. The enzyme called "ribonuclease" is a soluble protein of albumin type. Its molecular weight is about 15,000. Its isoelectric point is in the region of pH 8.0. 3.
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RNA-Binding Proteins Driving the Regulatory Activity of Small Non-coding RNAs in Bacteria
Frontiers in Molecular Biosciences, 2020 Small non-coding RNAs (sRNAs) are critical post-transcriptional regulators of gene expression. Distinct RNA-binding proteins (RBPs) influence the processing, stability and activity of bacterial small RNAs.
Ana P. Quendera +6 more
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Клиническая онкогематология, 2016 The article dwells on ribonucleases (RNAses) whose cytotoxic activity depends on the enzymatic activity, i.e. the ability to catalyze the cleavage of phosphodiester bonds of RNA.
Vadim Sergeevich Pokrovskii +3 more
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sRNA-mediated activation of gene expression by inhibition of 5'-3’ exonucleolytic mRNA degradation
eLife, 2017 Post-transcriptional control by small regulatory RNA (sRNA) is critical for rapid adaptive processes. sRNAs can directly modulate mRNA degradation in Proteobacteria without interfering with translation.
Sylvain Durand +4 more
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Microbial Biotechnology, 2021 Summary The development of synthetic biology has brought an unprecedented increase in the number molecular tools applicable into a microbial chassis.
Patrícia Apura +3 more
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