Results 11 to 20 of about 14,217 (304)

Isolation, Characterization, and Biocompatibility of Bisporitin, a Ribotoxin-like Protein from White Button Mushroom (Agaricus bisporus)

Biomolecules, 2023
White button mushroom (Agaricus bisporus (J.E. Lange) Imbach) is one of the widely consumed edible mushrooms. Indeed, A. bisporus fruiting bodies are a rich source of nutrients and bioactive molecules.
Sara Ragucci, Hafiza Zumra Fatima Hussain, Andrea Bosso, Nicola Landi, Angela Clemente, Paolo Vincenzo Pedone, Elio Pizzo, Antimo Di Maro   +7 more
doaj   +1 more source

Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication

Viruses, 2023
Viral replication often depends on RNA maturation and degradation processes catalyzed by viral ribonucleases, which are therefore candidate targets for antiviral drugs.
Abhishek Asthana, Angela Corona, Woo-Jin Shin, Mi-Jeong Kwak, Christina Gaughan, Enzo Tramontano, Jae U. Jung, Rainer Schobert, Babal Kant Jha, Robert H. Silverman, Bernhard Biersack   +10 more
doaj   +1 more source

Ribonucleases as potential therapeutic agents [PDF]

مجله بیوتکنولوژی کشاورزی, 2021
Objective Due to high cytotoxicity effect, ribonucleases (RNases) are known as pharmacological agents with therapeutic potential. The high potential of these enzymes in the destruction of RNA strand and their other substrates and subsequently, cell ...
Masoume Vakili-Azghandi, Mohammadreza Nasiri, Shahrokh Ghovvati, Ali Javadmanesh   +3 more
doaj   +1 more source

Ribonuclease-Responsive DNA Nanoswitches

Cell Reports Physical Science, 2020
Summary: DNA has been used in the construction of dynamic DNA devices that can reconfigure in the presence of external stimuli. These nanodevices have found uses in fields ranging from biomedical to materials science applications.
Arun Richard Chandrasekaran, Ruju Trivedi, Ken Halvorsen   +2 more
doaj   +1 more source

Dual RNase and β-lactamase Activity of a Single Enzyme Encoded in Archaea

Life, 2020
β-lactam antibiotics have a well-known activity which disturbs the bacterial cell wall biosynthesis and may be cleaved by β-lactamases. However, these drugs are not active on archaea microorganisms, which are naturally resistant because of the lack of β ...
Seydina M. Diene, Lucile Pinault, Nicholas Armstrong, Said Azza, Vivek Keshri, Saber Khelaifia, Eric Chabrière, Gustavo Caetano-Anolles, Jean-Marc Rolain, Pierre Pontarotti, Didier Raoult   +10 more
doaj   +1 more source

Developing New Tools to Fight Human Pathogens: A Journey through the Advances in RNA Technologies

Microorganisms, 2022
A long scientific journey has led to prominent technological advances in the RNA field, and several new types of molecules have been discovered, from non-coding RNAs (ncRNAs) to riboswitches, small interfering RNAs (siRNAs) and CRISPR systems.
Vanessa G. Costa, Susana M. Costa, Margarida Saramago, Marta V. Cunha, Cecília M. Arraiano, Sandra C. Viegas, Rute G. Matos   +6 more
doaj   +1 more source

RNA-Binding Proteins Driving the Regulatory Activity of Small Non-coding RNAs in Bacteria

Frontiers in Molecular Biosciences, 2020
Small non-coding RNAs (sRNAs) are critical post-transcriptional regulators of gene expression. Distinct RNA-binding proteins (RBPs) influence the processing, stability and activity of bacterial small RNAs.
Ana P. Quendera, André F. Seixas, Ricardo F. dos Santos, Inês Santos, João P. N. Silva, Cecília M. Arraiano, José M. Andrade   +6 more
doaj   +1 more source

The nsp15 Nuclease as a Good Target to Combat SARS-CoV-2: Mechanism of Action and Its Inactivation with FDA-Approved Drugs

Microorganisms, 2022
The pandemic caused by SARS-CoV-2 is not over yet, despite all the efforts from the scientific community. Vaccination is a crucial weapon to fight this virus; however, we still urge the development of antivirals to reduce the severity and progression of ...
Margarida Saramago, Vanessa G. Costa, Caio S. Souza, Cátia Bárria, Susana Domingues, Sandra C. Viegas, Diana Lousa, Cláudio M. Soares, Cecília M. Arraiano, Rute G. Matos   +9 more
doaj   +1 more source

Human Antimicrobial RNases Inhibit Intracellular Bacterial Growth and Induce Autophagy in Mycobacteria-Infected Macrophages

Frontiers in Immunology, 2019
The development of novel treatment against tuberculosis is a priority global health challenge. Antimicrobial proteins and peptides offer a multifaceted mechanism suitable to fight bacterial resistance.
Lu Lu, Javier Arranz-Trullén, Javier Arranz-Trullén, Guillem Prats-Ejarque, David Pulido, Sanjib Bhakta, Ester Boix   +6 more
doaj   +1 more source

The compactness of ribonuclease A and reduced ribonuclease A

FEBS Letters, 1998
The compactness of ribonuclease A with intact disulfide bonds and reduced ribonuclease A was investigated by synchrotron small‐angle X‐ray scattering. The R g values and the Kratky plots showed that non‐reduced ribonuclease A maintain a compact shape with a R g value of about 17.3 Å in 8 M urea.
Zhou, Jun-Mei, Fan, Ying-Xin, Kihara, Hiroshi, Kimura, Kazumoto, Amemiya, Yoshiyuki   +4 more
openaire   +2 more sources