Results 51 to 60 of about 21,043 (311)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The Immunomodulatory and Antimicrobial Properties of the Vertebrate Ribonuclease A Superfamily
Vaccines, 2018 The Ribonuclease A Superfamily is composed of cationic peptides that are secreted by immune cells and epithelial tissues. Although their physiological roles are unclear, several members of the vertebrate Ribonuclease A Superfamily demonstrate ...
Laura Schwartz +3 more
doaj +1 more source
The evolutionary history of plant T2/S-type ribonucleases [PDF]
PeerJ, 2017 A growing number of T2/S-RNases are being discovered in plant genomes. Members of this protein family have a variety of known functions, but the vast majority are still uncharacterized.
Karolis Ramanauskas, Boris Igić
doaj +2 more sources
Strengths and Challenges of Secretory Ribonucleases as AntiTumor Agents
Pharmaceutics, 2021 Approaches to develop effective drugs to kill cancer cells are mainly focused either on the improvement of the currently used chemotherapeutics or on the development of targeted therapies aimed at the selective destruction of cancer cells by steering ...
Jessica Castro +3 more
doaj +1 more source
Transfer RNA-derived small RNAs in the cancer transcriptome [PDF]
, 2016 The cellular lifetime includes stages such as differentiation, proliferation, division, senescence and apoptosis.These stages are driven by a strictly ordered process of transcription dynamics.
A Dueck +38 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Secreted alkaline ribonucleases of micromycetes
Учёные записки Казанского университета: Серия Естественные науки, 2020 Many ribonucleases (RNases) have a selective cytotoxic effect on tumor cells. Of particular interest are enzymes that are phylogenetically distant from mammalian RNases, such as amphibian, fungal, and bacterial RNases, all insensitive to the action of ...
V.V. Ulyanova +5 more
doaj +1 more source
The role of co-opted ESCRT proteins and lipid factors in protection of tombusviral double-stranded RNA replication intermediate against reconstituted RNAi in yeast. [PDF]
PLoS Pathogens, 2017 Reconstituted antiviral defense pathway in surrogate host yeast is used as an intracellular probe to further our understanding of virus-host interactions and the role of co-opted host factors in formation of membrane-bound viral replicase complexes in ...
Nikolay Kovalev +3 more
doaj +1 more source
The roles of the exoribonucleases DIS3L2 and XRN1 in disease [PDF]
, 2016 RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases which are critical for the degradation of cytoplasmic RNAs ...
Jones, Christopher I +3 more
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source