Results 101 to 110 of about 10,117 (175)

Additional file 1 of Phylogenetic analysis and stress response of the plant U2 small nuclear ribonucleoprotein B″ gene family

, 2022
Additional file 1: Fig. S1. Formation of mature 17S U2 snRNP. The upper one is12S core particle, the middle one is 15S pre-mature particle, and the lower oneis 17S functional maturity particle. Continuous thin black lines represent U2 snRNA. Fig. S2. The design process of the whole article. Fig. S3.
Gao, Cong, Lu, Shuai, Zhou, Rong, Ding, Junjie, Fan, Jialiang, Han, Binying, Chen, Moxian, Wang, Baohua, Cao, Yunying   +8 more
openaire   +1 more source

Alternative Splicing Regulation in Metabolic Disorders

Obesity Reviews, Volume 26, Issue 9, September 2025.
ABSTRACT Alternative splicing (AS) is a fundamental mechanism for enhancing transcriptome diversity and regulating gene expression, crucial for various cellular processes and the development of complex traits. This review examines the role of AS in metabolic disorders, including obesity, weight loss, dyslipidemias, and metabolic syndrome.
Dorota Kaminska
wiley   +1 more source

A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor [PDF]

, 1997
We have identified a human splicing factor required for the second step of pre-mRNA splicing. This new protein, hPrp18, is 30% identical to the yeast splicing factor Prp18.
Horowitz, D. S., Krainer, A. R.
core   +1 more source

Additional file 2 of Phylogenetic analysis and stress response of the plant U2 small nuclear ribonucleoprotein B″ gene family

, 2022
Additional file 2: Table S1. Sequence summary of plant U2B″ gene phylogenetic analysis.
Gao, Cong, Lu, Shuai, Zhou, Rong, Ding, Junjie, Fan, Jialiang, Han, Binying, Chen, Moxian, Wang, Baohua, Cao, Yunying   +8 more
openaire   +1 more source

U1‐70K and U1A and tau pathogenesis in demented and non‐demented individuals with Down syndrome

Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.
Abstract INTRODUCTION Splicing protein mislocalization is associated with tau pathogenesis, but its role in Down syndrome (DS) is under‐investigated. METHODS Spliceosome associations with tau and plaque pathology were examined in frontal cortex from DS with dementia (DSD+) and without dementia (DSD−) using quantitative immunoblotting and ...
Sylvia E. Perez, Jennifer C. Miguel, Muhammad Nadeem, Michael Malek‐Ahmadi, Chadwick M. Hales, Elizabeth Head, Elliott J. Mufson   +6 more
wiley   +1 more source

Hopf bifurcation in a gene regulatory network model: Molecular movement causes oscillations [PDF]

, 2015
Gene regulatory networks, i.e. DNA segments in a cell which interact with each other indirectly through their RNA and protein products, lie at the heart of many important intracellular signal transduction processes.
Chaplain, M, Ptashnyk, M, Sturrock, M
core   +1 more source

The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site. [PDF]

, 2006
BACKGROUND: The U2 small nuclear ribonucleoprotein particle (snRNP) component SF3b1/SAP155 is the only spliceosomal protein known to be phosphorylated concomitant with splicing catalysis.
Becker, Walter, Czajkowska, Hanna, de Graaf, Katrin, Lilischkis, Richard, Lüscher, Bernhard, Packman, Len C, Rottmann, Sabine   +6 more
core   +2 more sources

The linked units of 5S rDNA and U1 snDNA of razor shells (Mollusca: Bivalvia: Pharidae) [PDF]

, 2011
[Abstract] The linkage between 5S ribosomal DNA and other multigene families has been detected in many eukaryote lineages, but whether it provides any selective advantage remains unclear.
A M González-Tizón, A Martínez-Lage, AM Domitrovich, AP Rooney, BM Tyler, C Branlant, CC Query, CL Will, D Bryant, D Posada, D Scherly, DC Cabral-de-Mello, DE Shippen-Lentz, DF Bogenhagen, DH Huson, DH Mathews, DL Swofford, DW Nelson, E Gornung, E Morzycka-Wroblewska, F Caradonna, F Pelliccia, G Drouin, I Cross, IL Hofacker, J Douet, J Felsestein, J Fernández-Tajes, J Vierna, J Vierna, J Vierna, JE Medlin, JS Reuter, K Brehm, K T Jensen, K Tamura, M Fernandez, M Fujiwara, M Manchado, M Marz, M Nei, M Úbeda-Manzanaro, MA Larkin, MZ Barciszewska, N Hernandez, N Hernandez, O Gascuel, P Cuello, P Librado, P Nguyen, P Richard, P Veltos, PCH Lo, PM Datson, R Barzotti, R Cosel von, R Cosel von, R Freire, R Giegerich, R Kalendar, RC Peterson, RD Little, S Cohen, S Guindon, S Sharp, S-H Chen, SJ Sharp, SM Mount, T Pieler, TA Hall, TH Eickbush, TL Bailey, Y Huang, Y Zhuang, Z Zamrod   +74 more
core   +2 more sources

A unified mechanism for intron and exon definition and back-splicing. [PDF]

, 2019
The molecular mechanisms of exon definition and back-splicing are fundamental unanswered questions in pre-mRNA splicing. Here we report cryo-electron microscopy structures of the yeast spliceosomal E complex assembled on introns, providing a view of the ...
Cui, Yanxiang, Das, Rhiju, Espinosa, Sara, Hansen, Kirk C, Hill, Ryan C, Issaian, Aaron, Kappel, Kalli, Li, Xueni, Liu, Shiheng, Shi, Shasha, Zhang, Lingdi, Zhao, Rui, Zhou, Z Hong   +12 more
core  

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama, Bruce C. Richardson, Dipak Patel, Faith M. Strickland, Sushma Yarlagadda   +4 more
core   +1 more source