Results 41 to 50 of about 10,117 (175)

Structural basis for dual roles of Aar2p in U5 snRNP assembly [PDF]

, 2013
Yeast U5 small nuclear ribonucleoprotein particle (snRNP) is assembled via a cytoplasmic precursor that contains the U5-specific Prp8 protein but lacks the U5-specific Brr2 helicase.
Beggs, J.D., Cristão, V.F., Heroven, A.C., Holton, N., Jovin, S.M., Lührmann, R., Santos, K.F., Wahl, M.C., Weber, G.   +8 more
core   +1 more source

Friend of Prmt1, FOP is a novel component of the nuclear SMN complex isolated using biotin affinity purification [PDF]

, 2014
SMN (survival motor neuron protein) complexes are essential for the biogenesis of uridine-rich small nuclear ribonucleoproteins (UsnRNPs). During the biogenesis, the SMN complexes bound to UsnRNPs are transported from the cytoplasm to the nucleus, and ...
Ishikawa, H. (Hiroki), Isobe, T. (Toshiaki), Izumikawa, K. (Keiichi), Miyazawa, N. (Naoki), Nakayama, H. (Hiroshi), Nobe, Y. (Yuko), Philipsen, J.N.J. (Sjaak), Takahashi, N. (Nozomi), Taoka, M. (Masato), Terukina, G. (Goro), Yamauchi, N. (Naoto), Yoshikawa, H. (Harunori)   +11 more
core   +2 more sources

Interactions between Highly Conserved U2 Small Nuclear RNA Structures and Prp5p, Prp9p, Prp11p, and Prp21p Proteins Are Required To Ensure Integrity of the U2 Small Nuclear Ribonucleoprotein in Saccharomyces cerevisiae [PDF]

Molecular and Cellular Biology, 1994
Binding of U2 small nuclear ribonucleoprotein (snRNP) to the pre-mRNA is an early and important step in spliceosome assembly. We searched for evidence of cooperative function between yeast U2 small nuclear RNA (snRNA) and several genetically identified splicing (Prp) proteins required for the first chemical step of splicing, using the phenotype of ...
S E, Wells, M, Ares
openaire   +2 more sources

Arabidopsis U2AF65 Regulates Flowering Time and the Growth of Pollen Tubes

Frontiers in Plant Science, 2019
During pre-mRNA splicing, U2 small nuclear ribonucleoprotein auxiliary factor 65 (U2AF65) interacts with U2AF35 and splicing factor 1 (SF1), allowing for the recognition of the 3′-splice site by the ternary complex.
Hyo-Young Park, Hee Tae Lee, Jeong Hwan Lee, Jeong-Kook Kim   +3 more
doaj   +1 more source

RNA-binding protein immunoprecipitation as a tool to investigate plant miRNA processing interference by regulatory proteins of diverse origin [PDF]

, 2018
Background: Due to the nature of viral RNA genomes, RNA viruses depend on many RNA-binding proteins (RBP) of viral and host origin for replication, dissemination and evasion of host RNA degradation pathways.
Garcia, Maria Laura, Marmisollé, Facundo Ernesto, Reyes Martinez, Carina Andrea   +2 more
core   +2 more sources

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

Small nuclear ribonucleoprotein (RNP) U2 contains numerous additional proteins and has a bipartite RNP structure under splicing conditions. [PDF]

Molecular and Cellular Biology, 1993
Small nuclear (sn) ribonucleoprotein (RNP) U2 functions in the splicing of mRNA by recognizing the branch site of the unspliced pre-mRNA. When HeLa nuclear splicing extracts are centrifuged on glycerol gradients, U2 snRNPs sediment at either 12S (under high salt concentration conditions) or 17S (under low salt concentration conditions). We isolated the
S E, Behrens, K, Tyc, B, Kastner, J, Reichelt, R, Lührmann   +4 more
openaire   +2 more sources

SSB-1 of the yeast Saccharomyces cerevisiae is a nucleolar-specific, silver-binding protein that is associated with the snR10 and snR11 small nuclear RNAs [PDF]

, 1990
SSB-1, the yeast single-strand RNA-binding protein, is demonstrated to be a yeast nucleolar-specific, silver-binding protein. In double-label immunofluorescence microscopy experiments antibodies to two other nucleolar proteins, RNA Pol I 190-kD and ...
Abelson, John, Campbell, Judith, Clark, Michael W., Yip, Man Lun R.   +3 more
core   +2 more sources

Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer

Cell Reports
Summary: Triple negative breast cancer (TNBC) is an aggressive type of breast cancer. While most TNBCs are initially sensitive to chemotherapy, a substantial fraction acquires resistance to treatments and progresses to more advanced stages.
Cinzia Caggiano, Valerio Petrera, Miriana Ferri, Marco Pieraccioli, Eleonora Cesari, Alba Di Leone, Martin Alejandro Sanchez, Alessandra Fabi, Riccardo Masetti, Chiara Naro, Claudio Sette   +10 more
doaj   +1 more source

Fractionation and characterization of human small nuclear ribonucleoproteins containing U1 and U2 RNAs.

Journal of Biological Chemistry, 1983
Human small nuclear ribonucleoproteins (snRNPs) containing U1 and U2 snRNAs have been isolated from cultured cells by nonimmunological methods. The U1 snRNP population remained immunoprecipitable by systemic lupus erythematosis anti-RNP and anti-Sm antibodies throughout fractionation and contained polypeptides of molecular weights corresponding to ...
C S, Kinlaw, B L, Robberson, S M, Berget
openaire   +2 more sources