Results 51 to 60 of about 10,117 (175)

Splicing-factor alterations in cancers [PDF]

, 2016
Tumor-associated alterations in RNA splicing result either from mutations in splicing-regulatory elements or changes in components of the splicing machinery.
Anczukow, O., Krainer, A. R.
core   +1 more source

The U2 small nuclear ribonucleoprotein particle as an autoantigen. Analysis with sera from patients with overlap syndromes. [PDF]

Journal of Clinical Investigation, 1988
We identified eight patients whose sera contained autoantibodies to the U2 small nuclear ribonucleoprotein (snRNP), an RNA protein particle involved in the splicing of newly transcribed messenger RNA. Each of these patients had an overlap syndrome that included features of either systemic lupus erythematosus (SLE), scleroderma, and/or polymyositis.
J, Craft, T, Mimori, T L, Olsen, J A, Hardin   +3 more
openaire   +2 more sources

The U2 small nuclear ribonucleoprotein particle associates with nuclear factors in a pre-mRNA independent reaction.

Journal of Biological Chemistry, 1991
Northern blot analysis of HeLa cell nuclear extract following electrophoresis in nondenaturing gels revealed that a small proportion of U2 small nuclear ribonucleoprotein (snRNP) displays a low mobility, in confirmation of previous reports. This low mobility form of U2 snRNP (termed LMC, for low mobility complex) also formed in vitro when U2 snRNP ...
J, Temsamani, M, Rhoadhouse, T, Pederson
openaire   +2 more sources

A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II [PDF]

, 2014
Cajal bodies are nuclear structures that are involved in biogenesis of snRNPs and snoRNPs, maintenance of telomeres and processing of histone mRNA. Recently, the SUMO isopeptidase USPL1 was identified as a component of Cajal bodies that is essential for ...
Andersen, Baillat, Bauer, Blencowe, Boisvert, Boulisfane, Broome, Campion, Carmo-Fonseca, Chen, Cioce, Collier, Cox, Cox, Cuello, Darzacq, Dundr, Durocher, Egloff, Fischer, Fischer, Fischer, Fischer, Frey, Gabanella, Ganot, Gao, Hamm, Handwerger, Hegele, Hu, Huang, Huang, Hutten, Jacobs, Jao, Jawdekar, Jády, Kambach, Kiss, Kiss, Klingauf, Kunkel, Lange, Lemm, Lindgren, Listerman, Liu, Machyna, Makarov, Mao, Massenet, Matera, Matera, Mattaj, Medlin, Meulmeester, Morris, Mouaikel, Novotný, O'Keefe, Ong, Ong, Patel, Pellizzoni, Plessel, Polak, Raška, Reddy, Sauterer, Schaffert, Schulz, Shav-Tal, Shevchenko, Sleeman, Sleeman, Smith, Smith, Sowa, Spector, Spector, Spector, Spector, Stanek, Stanek, Strzelecka, Taneja, Tucker, Tycowski, Van Arsdell, Wahl, Westin, Will, Yin, Zhang, Zhao   +95 more
core   +5 more sources

Sex lethal and U2 small nuclear ribonucleoprotein auxiliary factor (U2AF⁶⁵) recognize polypyrimidine tracts using multiple modes of binding [PDF]

RNA, 2003
The molecular basis for specific recognition of simple homopolymeric sequences like the polypyrimidine tract (Py tract) by multiple RNA recognition motifs (RRMs) is not well understood. The Drosophila splicing repressor Sex lethal (SXL), which has two RRMs, can directly compete with the essential splicing factor U2AF65, which has three RRMs, for ...
Hiren, Banerjee, Andrew, Rahn, William, Davis, Ravinder, Singh   +3 more
openaire   +2 more sources

Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors [PDF]

, 1994
We have examined the functional significance of the organization of pre-mRNA splicing factors in a speckled distribution in the mammalian cell nucleus. Upon microinjection into living cells of oligonucleotides or antibodies that inhibit pre-mRNA splicing
Krainer, A. R., Mayeda, A., O'Keefe, R. T., Sadowski, C. L., Spector, D. L.   +4 more
core   +2 more sources

The 5' splice site consensus RNA oligonucleotide induces assembly of U2/U4/U5/U6 small nuclear ribonucleoprotein complexes. [PDF]

Proceedings of the National Academy of Sciences, 1992
A short RNA oligonucleotide comprising the 5' splice site consensus sequence (5'SS RNA oligo) efficiently inhibits splicing of mRNA precursors in HeLa cell nuclear extracts. Addition of 5'SS RNA oligo inhibits early, but not late, steps in the splicing reaction, affecting the process of spliceosome assembly. In the presence of 5'SS RNA oligo a majority
K B, Hall, M M, Konarska
openaire   +2 more sources

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

Arthritis &Rheumatology, Accepted Article.
Abstract. Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and post‐transcriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron ...
Luz P. Blanco, Binod Regmi, Carmelo Carmona‐Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong‐Wei Sun, Mariana J. Kaplan   +11 more
wiley   +1 more source

Identification of two distinct intron elements involved in alternative splicing of beta-tropomyosin pre-mRNA [PDF]

, 1990
The rat beta-tropomyosin gene encodes two isoforms, termed skeletal muscle beta-tropomyosin and fibroblast last tropomyosim 1 (TM-1), via an alternative RNA processing mechanism. The gene contains 11 exons.
Finn, L. A., Helfman, D. M., Mulligan, G. J., Roscigno, R. F., Weber, K. S.   +4 more
core   +1 more source

Leucine Periodicity of U2 Small Nuclear Ribonucleoprotein Particle (snRNP) A' Protein Is Implicated in snRNP Assembly via Protein-Protein Interactions [PDF]

Molecular and Cellular Biology, 1991
Recombinant A' protein could be reconstituted into U2 small nuclear ribonucleoprotein particles (snRNPs) upon addition to HeLa cell extracts as determined by coimmunoprecipitation and particle density; however, direct binding to U2 RNA could not be demonstrated except in the presence of the U2 snRNP B" protein.
L D, Fresco, D S, Harper, J D, Keene
openaire   +2 more sources