Results 81 to 90 of about 10,117 (175)

S-allylmercaptocysteine inhibits TLR4-mediated inflammation through enhanced formation of inhibitory MyD88 splice variant in mammary epithelial cells

Scientific Reports
Mastitis is an inflammatory disease affecting mammary tissues caused by bacterial infection that negatively affects milk quality and quantity. S-Allylmercaptocysteine (SAMC), a sulfur compound in aged garlic extract (AGE), suppresses lipopolysaccharide ...
Miyuki Takashima, Masahiro Kurita, Haruhi Terai, Feng-Qi Zhao, Jun-ichiro Suzuki   +4 more
doaj   +1 more source

The Influence of Cell Isolation and Culturing on Natriuretic Peptide Receptors in Aortic Vascular Smooth Muscle Cells

Cells
Vascular smooth muscle cell (SMC) relaxation by guanylyl cyclases (GCs) and cGMP is mediated by NO and its receptor soluble GC (sGC) or natriuretic peptides (NPs) ANP/BNP and CNP with the receptors GC-A and GC-B, respectively.
Christine Rager, Tobias Klöpper, Sabine Tasch, Michael Raymond Whittaker, Betty Exintaris, Andrea Mietens, Ralf Middendorff   +6 more
doaj   +1 more source

A Block in Mammalian Splicing Occurring after Formation of Large Complexes Containing U1, U2, U4, U5, and U6 Small Nuclear Ribonucleoproteins [PDF]

Molecular and Cellular Biology, 1989
The assembly of mammalian pre-mRNAs into large 50S to 60S complexes, or spliceosomes, containing small nuclear ribonucleoproteins (snRNPs) leads to the production of splicing intermediates, 5' exon and lariat-3' exon, and the subsequent production of spliced products.
C H, Agris, M E, Nemeroff, R M, Krug
openaire   +2 more sources

Combinatorial Analyses of Pre‐mRNA Splicing‐Defective Mutants Reveal Differential Quantitative Requirements for Shelterin in Distinct Telomere Functions

Genes to Cells, Volume 30, Issue 6, November 2025.
Different telomere functions show distinct dependence on Rap1 protein levels revealed by analyses of pre‐mRNA splicing mutants. ABSTRACT Telomeres perform multiple functions to maintain genome stability, including telomere length regulation, chromosome end protection, and meiotic chromosome dynamics.
Miho Takeuchi, Yoko Otsubo, Junko Kanoh
wiley   +1 more source

Functioning of the Drosophila integral U1/U2 protein Snf independent of U1 and U2 small nuclear ribonucleoprotein particles is revealed by snf ⁺ gene dose effects [PDF]

Proceedings of the National Academy of Sciences, 1999
Snf, encoded by sans fille , is the Drosophila homolog of mammalian U1A and U2B′′ and is an integral component of U1 and U2 small nuclear ribonucleoprotein particles (snRNPs). Surprisingly, changes in the level of this housekeeping protein can specifically affect autoregulatory activity of the RNA-binding protein ...
T W, Cline, D Z, Rudner, D A, Barbash, M, Bell, R, Vutien   +4 more
openaire   +2 more sources

Exosomes in Intervertebral Disc Regeneration: Roles, Opportunities, and Challenges

Advanced NanoBiomed Research, Volume 5, Issue 10, October 2025.
Factors of Intervertebral Disc Degeneration Extracellular Matrix (ECM) Exosomes and Intervertebral Disc Degeneration (IVDD) Exosome‐Mediated Therapy for IVDD of Different Cell Sources Application of Engineered Exosomes in IVDD Clinical Application of Exosomes in IVDD Treatment Conclusion and Future Perspectives. Intervertebral disc degeneration (IVDD),
Xianglong Zhou, Tianyi Xia, Jiheng Xiao, Jianhui Xiang, Hanhong Fang, Haoran Zhou, Yiqiang Hu, Liming Xiong   +7 more
wiley   +1 more source

U1, U2, and U6 small nuclear ribonucleoproteins (snRNPs) are associated with large nuclear RNP particles containing transcripts of an amplified gene in vivo. [PDF]

Proceedings of the National Academy of Sciences, 1986
Nuclear ribonucleoprotein (RNP) complexes that contain intact transcripts of the amplified gene for CAD, the multifunctional protein that initiates UMP synthesis in Syrian hamster cells, have been released from nuclei of Syrian hamster cells as large particulate structures that sediment at the 200S region in a sucrose gradient.
R, Sperling, P, Spann, D, Offen, J, Sperling   +3 more
openaire   +2 more sources

A Prenatal Diagnosis of Verheij Syndrome in a Fetus Harboring a de novo PUF60 Variant

Clinical Case Reports, Volume 13, Issue 10, October 2025.
Here, we report the case of a fetus affected by multiple congenital anomalies (MCA) syndrome detected during the second trimester through ultrasound scan, in which a de novo pathogenetic variant in the PUF60 gene (NM_078480.3:c.382_383del; p.Met128ValfsTer11) was identified by trio‐based exome sequencing.
Catia Mio, Maria Orsaria, Alessandra Franzoni, Elisa Bregant, Elena Betto, Jessica Zucco, Eliana Demori, Giuseppe Damante, Flavio Faletra   +8 more
wiley   +1 more source

Revealing the role of U2AF1 in splicing regulation and chimeric RNA dynamics

Scientific Reports
U2 small nuclear ribonucleoprotein auxiliary factor 1 (U2AF1) gene is a pivotal splicing factor frequently mutated in various malignancies, including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).
Sangeen Khan, Yue Tang, Yangyang Guo, Jing Feng, Hui Wu, Zhenguo Song, Chengjuan Zhang, Fujun Qin   +7 more
doaj   +1 more source

Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency [PDF]

, 2014
The molecular basis of a significant number of cases of isolated growth hormone deficiency remains unknown. We describe three sisters affected with severe isolated growth hormone deficiency and pituitary hypoplasia caused by biallelic mutations in the ...
Ali Oghabian, Armand Gutiérrez‐Arumí, Bhupendra Verma, Gabriel Á Martos‐Moreno, Ivon Cuscó, Jesús Argente, Julie A Chowen, Luis A Pérez‐Jurado, Mikko J Frilander, Pfäffle R, Pérez Jurado LA, Raquel Flores   +11 more
core   +2 more sources