Conditional ATXN2L-Null in Adult Frontal Cortex CamK2a+ Neurons Does Not Cause Cell Death but Restricts Spontaneous Mobility and Affects the Alternative Splicing Pathway [PDF]
CellsThe Ataxin-2-like (ATXN2L) protein is required to survive embryonic development, as documented in mice with the constitutive absence of the ATXN2L Lsm, LsmAD, and PAM2 domains due to knock-out (KO) of exons 5–8 with a frameshift.
Jana Key +8 more
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SHQ1-related hypomyelinating leukodystrophy: A case report with imaging features and a homozygous variant [PDF]
Radiology Case ReportsSHQ1-related hypomyelinating leukodystrophy is an ultra-rare autosomal recessive disorder affecting the assembly of H/ACA ribonucleoproteins, leading to defective myelin formation and progressive neurological impairment.
Abdullah AlBathi, MBBS +2 more
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Neuronal messenger ribonucleoprotein transport follows an aging Lévy walk [PDF]
Nature Communications, 2018 The transport dynamics of messenger ribonucleoproteins in neurons is crucial to our neuronal functions, but the detail remains elusive. Song et al. show that they are transported along the dendrites in alternating run and rest phases with their own ...
Minho S. Song +3 more
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Compendium of Methods to Uncover RNA-Protein Interactions In Vivo
Methods and Protocols, 2021 Control of gene expression is critical in shaping the pro-and eukaryotic organisms’ genotype and phenotype. The gene expression regulatory pathways solely rely on protein–protein and protein–nucleic acid interactions, which determine the fate of the ...
Mrinmoyee Majumder +1 more
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Principles of RNA recruitment to viral ribonucleoprotein condensates in a segmented dsRNA virus
eLife, 2023 Rotaviruses transcribe 11 distinct RNAs that must be co-packaged prior to their replication to make an infectious virion. During infection, nontranslating rotavirus transcripts accumulate in cytoplasmic protein-RNA granules known as viroplasms that ...
Sebastian Strauss +6 more
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Frontiers in Cellular and Infection Microbiology, 2021 Host manipulation is a common strategy for invading pathogens. Trypanosoma cruzi, the causative agent of Chagas Disease, lives intracellularly within host cells.
Camila Gachet-Castro +6 more
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Noncanonical Functions and Cellular Dynamics of the Mammalian Signal Recognition Particle Components
Frontiers in Molecular Biosciences, 2021 The signal recognition particle (SRP) is a ribonucleoprotein complex fundamental for co-translational delivery of proteins to their proper membrane localization and secretory pathways.
Camilla Faoro, Sandro F. Ataide
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The Role of RNA Binding Proteins for Local mRNA Translation: Implications in Neurological Disorders
Frontiers in Molecular Biosciences, 2020 As neurons are one of the most highly polarized cells in our body, they require sophisticated cellular mechanisms to maintain protein homeostasis in their subcellular compartments such as axons and dendrites.
Maximilian Paul Thelen, Min Jeong Kye
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SMN post-translational modifications in spinal muscular atrophy
Frontiers in Cellular Neuroscience, 2023 Since its first identification as the gene responsible for spinal muscular atrophy (SMA), the range of survival motor neuron (SMN) protein functions has increasingly expanded.
Giulietta M. Riboldi +3 more
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Ribonucleoprotein Immunoprecipitation (RIP) Analysis [PDF]
BIO-PROTOCOL, 2020 RNAs and RNA-binding proteins (RBPs) can interact dynamically in ribonucleoprotein (RNP) complexes that play important roles in controlling gene expression programs. One of the powerful ways to investigate changes in the association of RNAs with an RBP of interest is by immunoprecipitation (IP) analysis of native RNPs.
Martindale, Jennifer +2 more
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