The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome
Biological Reviews, Volume 101, Issue 4, Page 1877-1903, August 2026.ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke +2 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 8, August 2026.One thousand nine hundred sixty‐two genes associated with HCC TKI treatment responsiveness were identified through an internal unbiased genome‐wide CRISPR/Cas9 screening. A comprehensive HCC TKI treatment response landscape was constructed by integrating 20 datasets comprising a total of 322 TKI‐treated or TKI‐resistant HCC samples.
Si‐Yu Chen +10 more
wiley +1 more source
Resolving Sub-Nuclear Architecture from Compartments to Functional Domains. [PDF]
Int J Mol SciCavallo M +4 more
europepmc +1 more source
Overlap of Primary Biliary Cholangitis and Systemic Sclerosis: A Case of Reynolds Syndrome
Clinical Case Reports, Volume 14, Issue 8, August 2026.ABSTRACT Reynolds Syndrome should be suspected in CREST patients with persistent cholestatic liver enzymes, since delayed diagnosis allows portal hypertension and variceal bleeding to develop. Early anti‐mitochondrial antibody screening and prompt ursodeoxycholic acid therapy improve outcomes, and these patients need multidisciplinary follow‐up for ...
Ali Gohar +9 more
wiley +1 more source
FAST-CRISPR: Fusogenic Association and Secured Transfection of CRISPR/Cas9 Ribonucleoproteins Using Lipid-Silica Hybrid Nanoparticles for Therapeutic Genome Editing. [PDF]
SmallKim M +14 more
europepmc +1 more source
Deep Mutational Scanning for the Study and Engineering of Protein Assemblies
Chemistry–Methods, Volume 6, Issue 8, August 2026.This review explores how deep mutational scanning (DMS) can be used to improve understanding and accelerate engineering of protein assemblies, from natural fibers to engineered nanocages. We discuss various types of protein assemblies and their characterization, provide an introduction to the DMS technique, and then highlight examples in which DMS has ...
Jenna B. Wolfanger +2 more
wiley +1 more source
Regulation of chromatin dynamics by a calcium-dependent nucleoskeleton. [PDF]
J Biol ChemGonzález MJ +8 more
europepmc +1 more source
Generation and Characterization of a Rdh1‐iCre Line to Study Uterine Glandular Biology
genesis, Volume 64, Issue 4, August 2026.ABSTRACT The uterus is an essential organ for fetal development in most mammals. Uterine glands, highly conserved structures in the mammalian uterus, play critical roles in the establishment and maintenance of pregnancy and have been implicated in the pathogenesis of uterine diseases, including endometrial cancer and endometriosis.
Mana Ohtomo +11 more
wiley +1 more source
A working model for cytoplasmic assembly of H/ACA snoRNPs. [PDF]
FEBS LettAngrisani A, Furia M.
europepmc +1 more source