Results 111 to 120 of about 26,288 (294)

CRISPR-Cas12a ribonucleoprotein-mediated gene editing in the plant pathogenic fungus Magnaporthe oryzae

, 2021
Jun Huang, David E. Cook
openalex   +1 more source

Genome editing of a recalcitrant wine grape genotype by lipofectamine‐mediated delivery of CRISPR/Cas9 ribonucleoproteins to protoplasts [PDF]

Giorgio Gambino, Floriana Nuzzo, Amedeo Moine, Walter Chitarra, Chiara Pagliarani, Annalisa Petrelli, Paolo Boccacci, Andrea Delliri, Riccardo Velasco, Luca Nerva, Irene Perrone   +10 more
openalex   +1 more source

Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC‐Induced Degradation

Angewandte Chemie International Edition, EarlyView.
Proteolysis‐targeting chimeras (PROTACs) enable degradation of proteins previously considered undruggable by harnessing the cellular ubiquitin–proteasome system. In this study, Schäfer et al. identify thiazole‐based small molecules that allosterically bind the zinc finger domain of ubiquitin‐specific protease 39 (USP39), a non‐enzymatic scaffold ...
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source

Peripheral Fragile X messenger ribonucleoprotein is required for the timely closure of a critical period for neuronal susceptibility in the ventral cochlear nucleus [PDF]

, 2023
Xiaoyan Yu, Yuan Wang
openalex   +1 more source

PO-164 Identification of the heterogeneous nuclear ribonucleoprotein K/J (hnRNP K/J) as a repressor of the inhibitor kappa B alpha (IκBα) gene in aggressive breast cancer cells

, 2018
Guillaume Drouot, Vanessa Besancenot, A. Taverniers, Stéphanie Grandemange, Philippe Bécuwe, Nadège Touche   +5 more
openalex   +1 more source

Characterization of multiple alternative forms of heterogeneous nuclear ribonucleoprotein K by phosphate‐affinity electrophoresis [PDF]

, 2010
Yayoi Kimura, Kayoko Nagata, Nobutake Suzuki, Ryo Yokoyama, Yuko Yamanaka, Hiroshi Kitamura, Hisashi Hirano, Osamu Ohara   +7 more
openalex   +1 more source

Ribonucleoprotein [PDF]

, 2020
openaire   +1 more source

Case‐Based Immunology: B Cells and Systemic Sclerosis Interstitial Lung Disease

Arthritis &Rheumatology, EarlyView.
Interstitial lung disease (ILD) is an important complication of systemic sclerosis (SSc), with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to US Food and Drug Administration–approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of ILDs of other systemic autoimmune
Nina Goldman, Voon Ong, Christopher P. Denton   +2 more
wiley   +1 more source

A cooperative release of mitochondrial DNA from platelets and neutrophils drives an interferon signature in systemic sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective Mitochondria are organelles with a hypomethylated circular genome. Mitochondrial DNA (mtDNA) in the systemic circulation has been implicated in inflammation. This study investigates the role of circulating DNA in systemic sclerosis (SSc) and the cellular mechanisms governing its release.
Stavros Giaglis, André N. Tiaden, Simone Häner‐Massimi, Diego Kyburz, Cedric André, Anton Glück, Enrico Ferrero, Stuart Hawtin, Tobias Junt, Ulrich A. Walker   +9 more
wiley   +1 more source

Assembly of the U2 small nuclear ribonucleoprotein from Trypanosoma brucei. A mutational analysis

, 1993
Arthur Günzl, Mike Cross, Zsófia Pálfi, Albrecht Bindereif   +3 more
openalex   +1 more source