Results 141 to 150 of about 38,830 (350)

Topological barrier to Cas12a activation by circular DNA nanostructures facilitates autocatalysis and transforms DNA/RNA sensing

Nature Communications
Control of CRISPR/Cas12a trans-cleavage is crucial for biosensor development. Here, we show that small circular DNA nanostructures which partially match guide RNA sequences only minimally activate Cas12a ribonucleoproteins.
Fei Deng, Yi Li, Biyao Yang, Rui Sang, Wei Deng, Maya Kansara, Frank Lin, Subotheni Thavaneswaran, David M. Thomas, Ewa M. Goldys   +9 more
doaj   +1 more source

Structural characterization of the D290V mutation site in hnRNPA2 low-complexity-domain polymers. [PDF]

, 2018
Human genetic studies have given evidence of familial, disease-causing mutations in the analogous amino acid residue shared by three related RNA binding proteins causative of three neurological diseases. Alteration of aspartic acid residue 290 of hnRNPA2
Kato, Masato, McKnight, Steven L, Murray, Dylan T, Tycko, Robert, Xiang, Siheng, Zhou, Xiaoming   +5 more
core  

The centrosome and spindle as a ribonucleoprotein complex [PDF]

Chromosome Research, 2011
The notion of nucleic acids in the spindle, and particularly, the centrosome has a long history of inquiry, doubt, and debate. However, the association of specific RNAs with these structures is now confirmed by several investigators. What their presence means for the assembly, function, and evolution of the cell division apparatus is not known; but ...
openaire   +3 more sources

Beta cells to brain cells: The pivotal role of insulin and glucose metabolism in Alzheimer's disease

Neuroprotection, EarlyView.
Common metabolic, histochemical, and molecular pathologies: Type 2 diabetes and dementia. Abstract The risk factors and neuropathologies of cognitive decline and the onset and progression of dementia‐related disorders were, until recently, obtuse. A critical predisposing factor to Alzheimer's disease (AD) that has emerged is glucose dysmetabolism.
Stanley S. Schwartz, Elizabeth M. Rhea, William A. Banks, Mary E. Herman   +3 more
wiley   +1 more source

Editorial: Regulation of Soluble Immune Mediators by Non-Coding RNAs

Frontiers in Immunology, 2020
Daniela Bosisio, Flavia Bazzoni
doaj   +1 more source

Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu, Kyungdo Kim, Nicholas Asiimwe, Chan Hyun Na   +3 more
wiley   +1 more source

Help from the past to cope with the future: Vitis sylvestris as a resource for abiotic stress resilience

PLANTS, PEOPLE, PLANET, EarlyView.
Viticulture is facing increasing challenges due to climate change. The focus on fast growth and sweet berries has come at the expense of stress resilience. Grafting onto Phylloxera‐resistant rootstocks from American species has been the most successful form of ecological pest management.
Samia Daldoul, Islam M. Khattab, Faouzia Hanzouli, Imane Bahlouli, Peter Nick, Ahmed Mliki, Mahmoud Gargouri   +6 more
wiley   +1 more source

LABELLING OF IMMUNOLOGICALLY SPECIFIC PROTEINS BY RIBONUCLEOPROTEIN PARTICLES FROM RAT-LIVER AND CHICK-LIVER CELL SAP [PDF]

, 1963
ALEXANDRA VON DER DECKENA
openalex   +1 more source

The Actin‐Binding Prolyl‐Isomerase Par17 Sustains Its Substrate Selectivity by Interdomain Allostery

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The human peptidyl‐prolyl‐cis/trans isomerases (PPIases), Parvulin 14 and Parvulin 17, accelerate the cis/trans isomerization of Xaa‐Pro moieties within protein sequences. By modulating the respective binding interfaces of their target proteins, they play a crucial role in determining the fate of their substrates within the cell. Although both
Anna Sternberg, Jennifer Lynne Borger, Mathilda Thies, Anja Matena, Mike Blueggel, Bianca E. Kamba, Christine Beuck, Farnusch Kaschani, Markus Kaiser, Peter Bayer   +9 more
wiley   +1 more source

Formation of Ribosomes from Precursor Ribonucleoprotein Particles [PDF]

, 1965
Paul S. Sypherd
openalex   +1 more source