Results 191 to 200 of about 26,288 (294)

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins [PDF]

, 2014
Sojung Kim, Daesik Kim, Seung Woo Cho, Jung‐Eun Kim, Jin‐Soo Kim   +4 more
openalex   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Exploring the role and therapeutic potential of RNA N6-methyladenosine modification in abortion disease pathology: a comprehensive review. [PDF]

Front Genet
Chang Z, Li LH, Lv LZ, Wang ZD, Wang QY, Zhu H, Jiang B, Zhou XM, Han YP, Pan X, Ren L, Cheng S, Lei ZM.   +12 more
europepmc   +1 more source

Nucleotide-specific RNA conformations and dynamics within ribonucleoprotein condensates [PDF]

Tong Wang, Qingyue Hu, Scout Fronhofer, Lois Pollack   +3 more
openalex   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

¹²⁴I-labelled BMSC-Derived Extracellular Vesicles Deliver CRISPR/Cas9 Ribonucleoproteins With a GFP-Reporter System to Inhibit Osteosarcoma Proliferation and Metastasis. [PDF]

J Extracell Vesicles
Pan Y, Yang X, Zeng Z, Liu F, Luo J, Shen M, Zhou W, Li J, Jiang G, Sun L, Huang H, Pan R.   +11 more
europepmc   +1 more source

The Critical Role of mRNA Destabilizing Protein Heterogeneous Nuclear Ribonucleoprotein D in 3′ Untranslated Region–Mediated Decay of Low-Density Lipoprotein Receptor mRNA in Liver Tissue [PDF]

, 2013
Amar Singh, Hai Li, Chin Fung Kelvin Kan, Bin Dong, Mark R. Nicolls, Jingwen Liu   +5 more
openalex   +1 more source

Targeting Overexpressed IDO in Stromal Cells as a Potential Therapeutic Strategy in Multiple Myeloma

Cancer Science, EarlyView.
IDO expression in stromal cells was upregulated by MM cells via the JAK–STAT1–NF‐κB–IRF1 signaling pathway. JAK inhibitor abolished IDO and IRF1 upregulation. ABSTRACT Stromal cells are an essential component of the tumor microenvironment (TME) in multiple myeloma (MM). Indoleamine 2,3‐dioxygenase 1 (IDO), an enzyme that metabolizes tryptophan (Trp) to
Toru Ebina, Masaki Ri, Yoshiaki Marumo, Tomoyuki Nakamura, Hirokazu Sasaki, Yoshiko Oshima, Takahiro Nakashima, Shinya Hagiwara, Arisa Asano, Shiori Kinoshita, Tomotaka Suzuki, Tomoko Narita, Ayako Masaki, Takaomi Sanda, Kazufumi Yamagata, Kohmei Kubo, Hirokazu Komatsu, Hirotake Sakuraba, Shinsuke Iida   +18 more
wiley   +1 more source

Accelerating Cleavage Activity of CRISPR-Cas13 System on a Microfluidic Chip for Rapid Detection of RNA. [PDF]

Anal Chem
Kim J, Orozaliev A, Sahloul S, Van AD, Dang VT, Pham VS, Oh Y, Chehade I, Al-Sayegh M, Song YA.   +9 more
europepmc   +1 more source

Recruitment of Heterogeneous Nuclear Ribonucleoprotein A1in Vivo to the LMP/TAP Region of the Major Histocompatibility Complex [PDF]

, 2003
Rossen Donev, Roger W. Horton, Stephan Beck, Teodora A. Doneva, Radost Vatcheva, W. Richard Bowen, Denise Sheer   +6 more
openalex   +1 more source