Results 191 to 200 of about 38,830 (350)

Regulation of physiological and pathological condensates by molecular chaperones

open access: yesThe FEBS Journal, EarlyView.
Mounting evidence suggests that stress granules (SGs), dynamic membraneless compartments involved in cellular stress responses, can transition into pathological condensates upon improper disassembly. This review discusses the evidence supporting this notion.
Nadeen Akaree   +5 more
wiley   +1 more source

Ribonucleoprotein from a Rat Tumor, the Jensen Sarcoma

open access: hybrid, 1961
Mary L. Petermann, Amalia Pavlovec
openalex   +1 more source

A cellular model of TDP‐43 induces phosphorylated TDP‐43 aggregation with distinct changes in solubility and autophagy dysregulation

open access: yesThe FEBS Journal, EarlyView.
TDP‐43 protein plays a pathological role in sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we developed a cellular model overexpressing TDP‐43 with three mutations linked to familial ALS, termed ‘3X‐TDP‐43’. Mutant 3X‐TDP‐43 expression showed deficits in autophagy flux and colocalization with stress granules.
Matthew B. Dopler   +20 more
wiley   +1 more source

Past, present, and future strategies for detecting and quantifying circular RNA variants

open access: yesThe FEBS Journal, EarlyView.
Originally considered artifact of RNA splicing, over 3 million circular RNAs have been found in humans alone through a combination of ultrasensitive detection methods and bespoke bioinformatics tools. This review covers past, present, and future strategies for detecting and quantifying circular RNAs and how they are illuminating novel circular RNA ...
He Lin, Vanessa M. Conn, Simon J. Conn
wiley   +1 more source

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