Results 231 to 240 of about 38,830 (350)

Conformationally Locked Peptide–DNA Nanostructures for CRISPR‐Amplified Activity‐Based Sensing

Angewandte Chemie, Volume 137, Issue 25, June 17, 2025.
We report a new class of chemical probes, termed cleavable, locked initiator probes (CLIPs). CLIPs are peptide–DNA nanostructures resembling molecular beacons but enable activity‐based CRISPR‐amplified molecular sensing. CLIPs detect various disease‐relevant proteases, yield superior sensitivity compared to commercial probes, and enable the monitoring ...
Dylan M. Snider, Mackenzie L. Coffin, Brian J. Armijo, Ryan Khetan, Mark W. Duchow, Anna Capasso, Devleena Samanta   +6 more
wiley   +2 more sources

Rapid and robust validation of pooled CRISPR knockout screens using CelFi. [PDF]

Sci Rep
Loughran AJ, Narina S, Klein J, Siwak JF, Connelly JP, Pruett-Miller SM.   +5 more
europepmc   +1 more source

Formalin‐fixed paraffin‐embedded (FFPE) samples help to investigate transcriptomic responses in wildlife disease

Molecular Ecology Resources, Volume 25, Issue 5, July 2025.
Abstract Infectious diseases impact numerous organisms. Knowledge of host‐pathogen interactions and host responses to infection is crucial for conservation and management. Obtaining this knowledge quickly is made increasingly possible by a variety of genomic approaches, yet, for many species the bottleneck to understanding this, remains access to ...
Allison K. Miller, Cara L. Brosnahan, Anjali Pande, Cindy F. Baker, Jemma L. Geoghegan, Jane Kitson, Neil J. Gemmell, Edwina J. Dowle   +7 more
wiley   +1 more source

Isolation and visualization of large compact ribonucleoprotein particles of specific nuclear RNAs. [PDF]

, 1989
P. Spann, M Feinerman, Joseph M. Sperling, Ruth Sperling   +3 more
openalex   +1 more source

The Intricate Functional Networks of Pre-mRNA Alternative Splicing in Mammalian Spermatogenesis. [PDF]

Int J Mol Sci
Jiang N, Li Y, Yin L, Yuan S, Wang F.
europepmc   +1 more source

Dad's legacy: Epigenetic reprogramming and paternal inflammatory memory in offspring health

Journal of Internal Medicine, Volume 298, Issue 1, Page 16-30, July 2025.
Abstract Over the past decade, numerous reports have highlighted intergenerational and even transgenerational epigenetic effects resulting from parental exposure to diets, toxins, and stress. In many cases, these parentally induced phenotypes do not seem to confer an obvious benefit, making it challenging to understand the evolutionary drivers behind ...
Shamila D. Alipoor, Parisa Norouzitallab, Anita Öst, Maria Lerm   +3 more
wiley   +1 more source

Molecular cloning of cDNA for the nuclear ribonucleoprotein particle C proteins: a conserved gene family. [PDF]

, 1986
T Nakagawa, Maurice S. Swanson, B Wold, Gideon Dreyfuss   +3 more
openalex   +1 more source

Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo

Acta Pharmaceutica Sinica B
Extracellular vesicles (EVs) have recently emerged as a promising delivery platform for CRISPR/Cas9 ribonucleoproteins (RNPs), owing to their ability to minimize off-target effects and immune responses.
Yuanda Wan, Liren Li, Ruilin Chen, Jiajia Han, Qiyun Lei, Zhipeng Chen, Xiaodong Tang, Wenyu Wu, Shuwen Liu, Xingang Yao   +9 more
doaj  

Validation of Clinical-Grade Electroporation Systems for CRISPR-Cas9-Mediated Gene Therapy in Primary Hepatocytes for the Correction of Inherited Metabolic Liver Disease. [PDF]

Cells
Gibson J, Dhungana A, Pokhrel M, Arthur B, Suresh P, Adebayo O, Cottle RN.   +6 more
europepmc   +1 more source

Identification and Characterization of the Translationally Repressed Cytoplasmic Globin Messenger‐Ribonucleoprotein Particles from Duck Erythroblasts [PDF]

, 1980
Alain Vincent, Olivier Civelli, Kinsey Maundrell, Klaus Scherrer   +3 more
openalex   +1 more source