Results 201 to 210 of about 246,720 (281)

Description of 15 novel species within genus <i>Janthinobacterium</i> isolated from glaciers. [PDF]

Int J Syst Evol Microbiol
Yang LL, Xin YH, Liu Q.
europepmc   +1 more source

System level network data and models attack cancer drug resistance

British Journal of Pharmacology, EarlyView.
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély, Dávid Keresztes, Levente Szarka, Borbála M. Kovács, Klára Schulc, Dániel V. Veres, Peter Csermely   +6 more
wiley   +1 more source

Biosynthesis of Ribose-5-Phosphate-Metabolic Regulator of <i>Escherichia coli</i> Viability. [PDF]

Cells
Seregina TA, Shakulov RS, Petrushanko IY, Lobanov KV, Mironov AS.   +4 more
europepmc   +1 more source

Late blowing of Cheddar cheese induced by accelerated ripening and ribose and galactose supplementation in presence of a novel obligatory heterofermentative nonstarter Lactobacillus wasatchensis [PDF]

, 2015
Fatih Ortakcı, Jeffery R. Broadbent, C. J. Oberg, Donald J. McMahon   +3 more
openalex   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Chemical Synthesis of Native ADP-Ribosylated Oligonucleotides Enables Analysis of DNA ADP-Ribosylation Hydrolase Specificity. [PDF]

J Am Chem Soc
Tang L, Lu Y, van der Heijden FLAM, Chen Y, Jiang S, Meeuwenoord NJ, Liu L, Yu Z, Chen Z, Schuller M, Filippov DV, Ahel I, Liu Q.   +12 more
europepmc   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Glycation of alpha-synuclein enhances aggregation and neuroinflammatory responses. [PDF]

NPJ Parkinsons Dis
Vasili E, König A, Al-Azzani M, Bosbach C, Gatzemeier LM, Thom S, Chegão A, Vicente Miranda H, Steinem C, Erskine D, Outeiro TF.   +10 more
europepmc   +1 more source

Hydrolysis of O-Acetyl-ADP-ribose Isomers by ADP-ribosylhydrolase 3 [PDF]

, 2011
Atsushi Kasamatsu, Motoyuki Nakao, Brian C. Smith, Lindsay R. Comstock, Tohru Ono, Jiro Kato, John M. Denu, Joel Moss   +7 more
openalex   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source