Results 61 to 70 of about 534,315 (335)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Ribosomal small subunit sequence diversity of Scutellospora within single spores and roots of bluebell from a woodland community. [PDF]

, 1999
Roots of bluebell (Hyacinthoides nonscripta) were sampled from a woodland in Yorkshire,UK and spores of an arbuscular mycorrhizal fungus Scutellospora sp., were obtained from the surrounding soil.
Clapp, J.P., Fitter, A.H., Young, J.P.W.
core   +1 more source

Neurodegeneration-associated instability of ribosomal DNA

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014
Homologous recombination (HR)-mediated instability of the repetitively organized ribosomal DNA (rDNA) has been proposed as a mediator of cell senescence in yeast triggering the DNA damage response. High individual variability in the content of human rDNA suggests that this genomic region remained relatively unstable throughout evolution.
Hallgren, Justin, Pietrzak, Maciej, Rempala, Grzegorz, Nelson, Peter T., Hetman, Michal   +4 more
openaire   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

A New Isolate of the Genus Malassezia Based on the Sequence Analysis of 26S and ITS1 in Ribosomal DNA [PDF]

Cell Journal, 2009
Malassezia species considered to be the etiological agents of pityriasis versicolor andMalassezia follicolitis in humans. Recently, on the basis of molecular data, four new specieswere added to the genus.
Hossein Mirhendi, Ali Zia, Kuichi Makimura   +2 more
doaj  

Molecular and ultrastructure characterization of two nematodes (Thelandros scleratus and Physalopteroides dactyluris) based on ribosomal and mitochondrial DNA sequences

Helminthologia, 2016
The phylogenetic relationships of the nematode species Thelandros scleratus (Oxyurida: Pharyn-godonidae) and Physalopteroides dactyluris (Spirurida: Physalopteridae) were analyzed using the ribosomal 18S rRNAand the mitochondrial cytochrome C oxidase ...
Goswami U, Chaudhary A, Verma C, Singh H.S.   +3 more
doaj   +1 more source

Copy Number of Human Ribosomal Genes With Aging: Unchanged Mean, but Narrowed Range and Decreased Variance in Elderly Group

Frontiers in Genetics, 2018
Introduction: The multi-copied genes coding for the human 18, 5.8, and 28S ribosomal RNA (rRNA) are located in five pairs of acrocentric chromosomes forming so-called rDNA.
Elena M. Malinovskaya, Elizaveta S. Ershova, Vera E. Golimbet, Lev N. Porokhovnik, Nataliya A. Lyapunova, Serguey I. Kutsev, Natalia N. Veiko, Svetlana V. Kostyuk   +7 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

First Report of Hemicriconemoides kanayaensis (Nematoda: Criconematidae) on Tea Plantations in Iran

Journal of Nematology
During a nematode survey in Iran, an abundant population of sheathoid, migratory, root-ectoparasitic nematodes was recovered from a tea, Camellia sinensis (L.), Kuntze plantation for the first time. Morphological and molecular characterization identified
Mirghasemi Negin, Fanelli Elena, Vovlas Alessio, Troccoli Alberto, Jamali Salar, De Luca Francesca   +5 more
doaj   +1 more source

A Unifying Scenario on the Origin and Evolution of Cellular and Viral Domains [PDF]

, 2009
The cellular theory on the nature of life has been one of the first major advancements in biology. Viruses, however, are the most abundant life forms, and their exclusion from mainstream biology and the Tree of Life (TOL) is a major paradox in biology ...
Claudiu I. Bandea
core   +1 more source