Results 71 to 80 of about 2,892,023 (342)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

The impact of molecular biology on assessment of water quality: advantages and limitations of current techniques [PDF]

, 1997
The advent of molecular biology has had a dramatic impact on all aspects of biology, not least applied microbial ecology. Microbiological testing of water has traditionally depended largely on culture techniques.
Saunders, J.R., Saunders, V.A.
core  

ADAR1 restricts LINE-1 retrotransposition [PDF]

, 2016
Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosines to inosines in double-stranded RNAs. ADAR1 was demonstrated to be functional on different viruses exerting either antiviral or proviral effects.
Antonioni, Ambra, Ciafré, Silvia Anna, Doria, Margherita, Frassinelli, Loredana, Galardi, Silvia, Mancone, Carmine, Michienzi, Alessandro, Montaldo, Claudia, Orecchini, Elisa, Tripodi, Marco   +9 more
core   +2 more sources

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Real-time assembly of ribonucleoprotein complexes on nascent RNA transcripts. [PDF]

, 2018
Cellular protein-RNA complexes assemble on nascent transcripts, but methods to observe transcription and protein binding in real time and at physiological concentrations are not available.
Duss, Olivier, Grot, Annette, O'Leary, Seán E, Puglisi, Joseph D, Stepanyuk, Galina A, Williamson, James R   +5 more
core   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Fluorescent in situ hybridization of the ribosomal RNA genes (5S and 35S) in the genus Lolium: Lolium canariense, the missing link with Festuca?

Anales del Jardín Botánico de Madrid, 2013
Two groups of taxa can be distinguished within the genus Lolium L. based on the pollination system, chromosome size, chromosomal location of nrDNA (5S and 35S (18S-5.8S-26S)] and nrDNA phylogeny.
Luis A. Inda, Elzbieta Wolny
doaj   +1 more source

Organization and expression analysis of 5S and 45S ribosomal DNA clusters in autotetraploid Carassius auratus

BMC Ecology and Evolution, 2021
Background Autotetraploid Carassius auratus (4n = 200, RRRR) (abbreviated as 4nRR) is derived from whole genome duplication of Carassius auratus red var. (2n = 100, RR) (abbreviated as RCC).
Chun Zhao, Yuxin Zhang, Huan Qin, Chongqing Wang, Xu Huang, Li Yang, Tingting Yu, Xidan Xu, Xiang Luo, Qinbo Qin, Shaojun Liu   +10 more
doaj   +1 more source

Mild cognitive impairment is associated with low copy number of ribosomal genes in the genomes of elderly people

Frontiers in Genetics, 2022
Introduction: Mild cognitive impairments (MCI) accompanying aging are associated with oxidative stress. The ability of cells to respond to stress is determined by the protein synthesis level, which depends on the ribosomes number.
Natalia N. Veiko, Elizaveta S. Ershova, Elizaveta S. Ershova, Roman V. Veiko, Pavel E. Umriukhin, Pavel E. Umriukhin, Pavel E. Umriukhin, Marat V. Kurmyshev, Georg P. Kostyuk, Sergey I. Kutsev, Svetlana V. Kostyuk, Svetlana V. Kostyuk   +11 more
doaj   +1 more source

Recent advances in exploring physiology and biodiversity of ectomycorrhizas highlight the functioning of these symbioses in ecosystems [PDF]

, 2000
Ectomycorrhizas, the dominating mycorrhizal symbiosis in boreal, temperate and some tropical forests, are formed by 5000-6000 species of the asco- and basidiomycetes.
Buscot, François, Charcosset, Jean-Yves, Gardes, Monique, Hampp, Rüdiger, Munch, Jean Charles, Nehls, Uwe   +5 more
core   +1 more source