Results 1 to 10 of about 492,027 (288)
Mild cognitive impairment is associated with low copy number of ribosomal genes in the genomes of elderly people [PDF]
Frontiers in Genetics, 2022 Introduction: Mild cognitive impairments (MCI) accompanying aging are associated with oxidative stress. The ability of cells to respond to stress is determined by the protein synthesis level, which depends on the ribosomes number.
Natalia N. Veiko +11 more
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Copy Number of Human Ribosomal Genes With Aging: Unchanged Mean, but Narrowed Range and Decreased Variance in Elderly Group [PDF]
Frontiers in Genetics, 2018 Introduction: The multi-copied genes coding for the human 18, 5.8, and 28S ribosomal RNA (rRNA) are located in five pairs of acrocentric chromosomes forming so-called rDNA.
Elena M. Malinovskaya +7 more
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Intron dynamics in ribosomal protein genes. [PDF]
PLoS ONE, 2007 The role of spliceosomal introns in eukaryotic genomes remains obscure. A large scale analysis of intron presence/absence patterns in many gene families and species is a necessary step to clarify the role of these introns.
Maki Yoshihama +2 more
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Many ribosomal protein genes are cancer genes in zebrafish. [PDF]
PLoS Biology, 2004 We have generated several hundred lines of zebrafish (Danio rerio), each heterozygous for a recessive embryonic lethal mutation. Since many tumor suppressor genes are recessive lethals, we screened our colony for lines that display early mortality and/or
Adam Amsterdam +6 more
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Evidence for further non-coding RNA genes in the fungal rDNA region [PDF]
MycoKeys, 2022 Non-coding RNA (ncRNA) genes play important, but incompletely understood, roles in various cellular processes, notably translation and gene regulation.
Magnus Alm Rosenblad +5 more
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Cells, 2021 In human cells, each rDNA unit consists of the ~13 kb long ribosomal part and ~30 kb long intergenic spacer (IGS). The ribosomal part, transcribed by RNA polymerase I (pol I), includes genes coding for 18S, 5.8S, and 28S RNAs of the ribosomal particles ...
Evgeny Smirnov +2 more
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Bacterial protein interaction networks: connectivity is ruled by gene conservation, essentiality and function [PDF]
, 2020 Protein-protein interaction (PPI) networks are the backbone of all processes in living cells. In this work we relate conservation, essentiality and functional repertoire of a gene to the connectivity $k$ of the corresponding protein in the PPI networks ...
Cimini, Giulio +2 more
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p53 represses ribosomal gene transcription [PDF]
Oncogene, 1999 Induction of the tumor suppressor protein p53 restricts cellular proliferation. Since actively growing cells require the ongoing synthesis of ribosomal RNA to sustain cellular biosynthesis, we studied the effect of p53 on ribosomal gene transcription by RNA polymerase I (Pol I).
A, Budde, I, Grummt
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Plants, 2023 The target of rapamycin (TOR) protein phosphorylates its downstream effector p70kDa ribosomal protein S6 kinases (S6K1) for ribosome biogenesis and translation initiation in eukaryotes.
Achala Bakshi +6 more
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Ribosomal RNA genes in Mycoplasma [PDF]
Nucleic Acids Research, 1982 Using Southern blotting analysis with labelled mycoplasmal ribosomal RNA as probe, two fragments (1 Kb and 5 Kb) were detected in an EcoR I digest of Mycoplasma capricolum DNA. This analysis revealed that the 5 Kb fragment carries both 16S rRNA sequences and the entire 23S rRNA gene of this mycoplasma. The 1 Kb fragment contains 16S rRNA sequences only.
D, Amikam, S, Razin, G, Glaser
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